Endometriosis Knowledgebase

Search Result

Gene id

200424

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

TET3 Gene UCSC Ensembl

Aliases

hCG_40738

Gene name

tet methylcytosine dioxygenase 3

Alternate names

methylcytosine dioxygenase TET3, probable methylcytosine dioxygenase TET3, putative methylcytosine dioxygenase, tet oncogene family member 3,

Gene location

2p13.1 (13836658: 13836586) Exons: 1 NC_000019.10

Gene summary(Entrez)

Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]

OMIM

613555

Protein Summary

Protein general information

O43151

Name: Methylcytosine dioxygenase TET3 (EC 1.14.11.n2)

Length: 1660 Mass: 179,350

Tissue specificity: Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes. {ECO

Sequence

MDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAV
SSYGALSTRLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEW
LEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAI
EALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPE
AWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPAPSPVLQRE
APTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTP
AGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPP
EPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDP
ENQQTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPT
KSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSS
RGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGL
NDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRL
APQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQL
HVLPLYKMANTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPE
KIKQEALELAGITSDPGLSLKGGLSQQGLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGNCRPSDPYSMNSVYSY
HSYYAQPSLTSVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSSGSFEKKPDLHALHNSLSPAYGGA
EFAELPSQAVPTDAHHPTPHHQQPAYPGPKEYLLPKAPLLHSVSRDPSPFAQSSNCYNRSIKQEPVDPLTQAEPV
PRDAGKMGKTPLSEVSQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFSSGESPAIVPDKLSSFGASCLAPSHF
TDGQWGLFPGEGQQAASHSGGRLRGKPWSPCKFGNSTSALAGPSLTEKPWALGAGDFNSALKGSPGFQDKLWNPM
KGEEGRIPAAGASQLDRAWQSFGLPLGSSEKLFGALKSEEKLWDPFSLEEGPAEEPPSKGAVKEEKGGGGAEEEE
EELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWE
AKMKQLAERARARQEEAARLGLGQQEAKLYGKKRKWGGTVVAEPQQKEKKGVVPTRQALAVPTDSAVTVSSYAYT
KVTGPYSRWI

Structural information

Interpro:	IPR024779
Pfam:	PF12851
PDB:	4Z3C
PDBsum:	4Z3C
MINT:
STRING:	ENSP00000386869;

Other Databases

GeneCards: TET3; Malacards: TET3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001939	female pronucleus	IEA	cellular_component
GO:0001940	male pronucleus	ISS	cellular_component
GO:0003677	DNA binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005737	cytoplasm	ISS	cellular_component
GO:0006493	protein O-linked glycosyl ation	IMP	biological_process
GO:0044727	DNA demethylation of male pronucleus	ISS	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IMP	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0055114	oxidation-reduction proce ss	IEA	biological_process
GO:0070579	methylcytosine dioxygenas e activity	ISS	molecular_function
GO:0080111	DNA demethylation	ISS	biological_process
GO:0080182	histone H3-K4 trimethylat ion	IMP	biological_process
GO:0001939	female pronucleus	IEA	cellular_component
GO:0001940	male pronucleus	IEA	cellular_component
GO:0001940	male pronucleus	ISS	cellular_component
GO:0003677	DNA binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	ISS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006493	protein O-linked glycosyl ation	IMP	biological_process
GO:0007275	multicellular organism de velopment	IEA	biological_process
GO:0016491	oxidoreductase activity	IEA	molecular_function
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or red uction of molecular oxyge n, 2-oxoglutarate as one donor, and incorporation of one atom each of oxyge n into both donors	IEA	molecular_function
GO:0044727	DNA demethylation of male pronucleus	IEA	biological_process
GO:0044727	DNA demethylation of male pronucleus	ISS	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IMP	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0051213	dioxygenase activity	IEA	molecular_function
GO:0055114	oxidation-reduction proce ss	IEA	biological_process
GO:0070579	methylcytosine dioxygenas e activity	IEA	molecular_function
GO:0070579	methylcytosine dioxygenas e activity	ISS	molecular_function
GO:0080111	DNA demethylation	IEA	biological_process
GO:0080111	DNA demethylation	ISS	biological_process
GO:0080182	histone H3-K4 trimethylat ion	IMP	biological_process
GO:0001940	male pronucleus	ISS	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005737	cytoplasm	ISS	cellular_component
GO:0006493	protein O-linked glycosyl ation	IMP	biological_process
GO:0044727	DNA demethylation of male pronucleus	ISS	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IMP	biological_process
GO:0070579	methylcytosine dioxygenas e activity	ISS	molecular_function
GO:0080111	DNA demethylation	ISS	biological_process
GO:0080182	histone H3-K4 trimethylat ion	IMP	biological_process

Diseases

Associated diseases	References
Leukemia	GAD19420352
Endometriosis	PubMed26917261

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
26917261	Endometrio sis						Show abstract