Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 3308
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol HSPA4   Gene   UCSC   Ensembl
Aliases APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
Gene name heat shock protein family A (Hsp70) member 4
Alternate names heat shock 70 kDa protein 4, epididymis secretory sperm binding protein Li 5a, heat shock 70-related protein APG-2, heat shock 70kD protein 4, heat shock 70kDa protein 4, heat shock protein, 110 kDa, hsp70 RY,
Gene location 5q31.1 (133051969: 133105016)     Exons: 19     NC_000005.10
OMIM 601113

Protein Summary
Protein general information P34932  

Name: Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70 related protein APG 2)

Length: 840  Mass: 94,331

Sequence MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQGFKRFHGRAF
SDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVLKKPVVDCVVSVPCFYTD
AERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLAT
AFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGT
MNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRG
CALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFYRKEPFTLEAYYSSPQ
DLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQNAKEEEKMQVD
QEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIENQLLWQIDREMLNLYIEN
EGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKL
AELKNLGQPIKIRFQESEERPKLFEELGKQIQQYMKIISSFKNKEDQYDHLDAADMTKVEKSTNEAMEWMNNKLN
LQNKQSLTMDPVVKSKEIEAKIKELTSTCSPIISKPKPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQGTDTA
VPSDSDKKLPEMDID
Structural information
Interpro:  IPR018181 IPR029048 IPR029047 IPR013126
Prosite:   PS00329 PS01036

Pfam:  		 PF00012

DIP:  		 460
MINT:   1159519
STRING:   ENSP00000302961;
Other Databases GeneCards:  HSPA4;  Malacards:  HSPA4

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005515 protein binding
 IPI molecular_function
GO:0005524 ATP binding
 NAS molecular_function
GO:0005829 cytosol
 IDA cellular_component
GO:0006986 response to unfolded prot
ein
 NAS biological_process
GO:0045040 protein import into mitoc
hondrial outer membrane
 IDA biological_process
GO:0051131 chaperone-mediated protei
n complex assembly
 IDA biological_process
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0000166 nucleotide binding
 IEA molecular_function
GO:0005515 protein binding
 IPI molecular_function
GO:0005524 ATP binding
 IEA molecular_function
GO:0005524 ATP binding
 NAS molecular_function
GO:0005737 cytoplasm
 IEA cellular_component
GO:0005737 cytoplasm
 IEA cellular_component
GO:0005829 cytosol
 IDA cellular_component
GO:0006986 response to unfolded prot
ein
 NAS biological_process
GO:0045040 protein import into mitoc
hondrial outer membrane
 IDA biological_process
GO:0051131 chaperone-mediated protei
n complex assembly
 IDA biological_process
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0005515 protein binding
 IPI molecular_function
GO:0005524 ATP binding
 NAS molecular_function
GO:0005829 cytosol
 IDA cellular_component
GO:0006986 response to unfolded prot
ein
 NAS biological_process
GO:0045040 protein import into mitoc
hondrial outer membrane
 IDA biological_process
GO:0051131 chaperone-mediated protei
n complex assembly
 IDA biological_process
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component

KEGG pathways

hsa04612  Antigen processing and presentation
hsa04530  Tight junction

Diseases

Associated diseases References
Asthenozoospermia PMID: 20369545
Bipolar disorder PMID: 19766166
Connective tissue diseases PMID: 19527514
Endometriosis PMID: 9207579
Male infertility PMID: 17880957
Oligozoospermia PMID: 20096881
Recurrent pregnancy loss (RPL)/ Abortion/ Miscarriage/ Recurrent pregnancy failure/Pregnancy loss/ Recurrent miscarriage/ Spontaneous abortion PMID: 28272721
Polycystic ovary syndrome (PCOS) PMID: 23825680
Preeclampsia PMID: 23382911
Endometriosis INFBASE9207579
Preterm delivery PMID: 15507967
Varicocele PMID: 23603921
Varicocele PMID: 23540861

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21333981 Endometrio
sis
38 (18 with end
ometriosis, 20
without endomet
riosis)
 HSP70
 Show abstract
9207579 Endometrio
sis
119 women with
endometriosis o
r adenomyosis (
38 fertile cont
rol, 38 endomet
riosis, 43 aden
omyosis, 33 who
underwent hyst
erectomy, 10 tr
eated with dana
zol )
 HSP27
HSP70
 Show abstract