Endometriosis Knowledgebase

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Gene id

3310

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

HSPA6 Gene UCSC Ensembl

Aliases

HSP70B'

Gene name

heat shock protein family A (Hsp70) member 6

Alternate names

heat shock 70 kDa protein 6, heat shock 70 kDa protein B', heat shock 70kD protein 6 (HSP70B'), heat shock 70kDa protein 6 (HSP70B'),

Gene location

1q23.3 (161524539: 161526896) Exons: 1 NC_000001.11

OMIM

140555

Protein Summary

Protein general information

P17066

Name: Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B')

Length: 643 Mass: 71,028

Sequence

MQAPRELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDAKRL
IGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYLGQPVKHAVITVPA
YFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDLGGGTFDVSVLSIDAGVFEVKATA
GDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSIT
RARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGA
AVQAAVLMGDKCEKVQDLLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERA
MTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAE
QYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEKEEYEHQKRE
LEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPSTGPIIEEVD

Structural information

Interpro:	IPR018181 IPR029048 IPR029047 IPR013126
Prosite:	PS00297 PS00329 PS01036
Pfam:	PF00012
PDB:	3FE1
PDBsum:	3FE1
MINT:	1139180
STRING:	ENSP00000310219;

Other Databases

GeneCards: HSPA6; Malacards: HSPA6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005814	centriole	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0006986	response to unfolded prot ein	TAS	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0031072	heat shock protein bindin g	IPI	molecular_function
GO:0034605	cellular response to heat	IMP	biological_process
GO:0034605	cellular response to heat	IDA	biological_process
GO:0042026	protein refolding	IDA	biological_process
GO:0042623	ATPase activity, coupled	IDA	molecular_function
GO:0051082	unfolded protein binding	IDA	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0072562	blood microparticle	IDA	cellular_component
GO:0070370	cellular heat acclimation	IMP	biological_process
GO:0008180	COP9 signalosome	IDA	cellular_component
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005814	centriole	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0006986	response to unfolded prot ein	TAS	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0031072	heat shock protein bindin g	IPI	molecular_function
GO:0034605	cellular response to heat	IMP	biological_process
GO:0034605	cellular response to heat	IDA	biological_process
GO:0042026	protein refolding	IDA	biological_process
GO:0042623	ATPase activity, coupled	IDA	molecular_function
GO:0051082	unfolded protein binding	IDA	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0072562	blood microparticle	IDA	cellular_component
GO:0070370	cellular heat acclimation	IMP	biological_process
GO:0008180	COP9 signalosome	IDA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005814	centriole	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0006986	response to unfolded prot ein	TAS	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0031072	heat shock protein bindin g	IPI	molecular_function
GO:0034605	cellular response to heat	IMP	biological_process
GO:0034605	cellular response to heat	IDA	biological_process
GO:0042026	protein refolding	IDA	biological_process
GO:0042623	ATPase activity, coupled	IDA	molecular_function
GO:0051082	unfolded protein binding	IDA	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0072562	blood microparticle	IDA	cellular_component
GO:0070370	cellular heat acclimation	IMP	biological_process
GO:0008180	COP9 signalosome	IDA	cellular_component

KEGG pathways

hsa04010  MAPK signaling pathway
hsa05169  Epstein-Barr virus infection
hsa05164  Influenza A
hsa05145  Toxoplasmosis
hsa04144  Endocytosis
hsa05162  Measles
hsa04915  Estrogen signaling pathway
hsa04612  Antigen processing and presentation
hsa05134  Legionellosis
hsa04213  Longevity regulating pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa03040  Spliceosome

Diseases

Associated diseases	References
Cancer	PMID: 19074885
Connective tissue diseases	PMID: 19527514
Endometriosis	PMID: 18206876
Endometriosis	INFBASE18206876

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
18206876	Endometrio sis			66 (45 women ha d laparoscopica lly and histolo gically confirm ed endometriosi s, 21 women did not have endom etriosis)		HSP70b	Show abstract