Endometriosis Knowledgebase

Search Result

Gene id

5055

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

SERPINB2 Gene UCSC Ensembl

Aliases

HsT1201, PAI, PAI-2, PAI2, PLANH2

Gene name

serpin family B member 2

Alternate names

plasminogen activator inhibitor 2, monocyte Arg-serpin, placental plasminogen activator inhibitor, plasminogen activator inhibitor, type II (arginine-serpin), serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2, serpin B2, serpin peptidase ,

Gene location

18q21.33-q22.1 (63887704: 63903889) Exons: 9 NC_000018.10

OMIM

173390

Protein Summary

Protein general information

P05120

Name: Plasminogen activator inhibitor 2 (PAI 2) (Monocyte Arg serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor)

Length: 415 Mass: 46,596

Sequence

MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPEN
FTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYS
SEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVN
SAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKM
AEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGG
VMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP

Structural information

Interpro:	IPR015556 IPR023795 IPR023796 IPR000215
Prosite:	PS00284
Pfam:	PF00079
PDB:	1BY7 1JRR 2ARQ 2ARR
PDBsum:	1BY7 1JRR 2ARQ 2ARR
MINT:	270968
STRING:	ENSP00000299502;

Other Databases

GeneCards: SERPINB2; Malacards: SERPINB2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004867	serine-type endopeptidase inhibitor activity	IBA	molecular_function
GO:0004867	serine-type endopeptidase inhibitor activity	TAS	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005737	cytoplasm	IBA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0010951	negative regulation of en dopeptidase activity	IEA	biological_process
GO:0042060	wound healing	IEA	biological_process
GO:0042730	fibrinolysis	TAS	biological_process
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	molecular_function
GO:0004867	serine-type endopeptidase inhibitor activity	IBA	molecular_function
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	molecular_function
GO:0004867	serine-type endopeptidase inhibitor activity	TAS	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005737	cytoplasm	IBA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0010466	negative regulation of pe ptidase activity	IEA	biological_process
GO:0010951	negative regulation of en dopeptidase activity	IEA	biological_process
GO:0030414	peptidase inhibitor activ ity	IEA	molecular_function
GO:0042060	wound healing	IEA	biological_process
GO:0042730	fibrinolysis	TAS	biological_process
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0043066	negative regulation of ap optotic process	TAS	biological_process
GO:0004867	serine-type endopeptidase inhibitor activity	IBA	molecular_function
GO:0004867	serine-type endopeptidase inhibitor activity	TAS	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005737	cytoplasm	IBA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0042730	fibrinolysis	TAS	biological_process
GO:0043066	negative regulation of ap optotic process	TAS	biological_process

KEGG pathways

hsa04610 Complement and coagulation cascades

Diseases

Associated diseases	References
Cancer	PMID: 19117638
Cerebral palsy	PMID: 19238444
Cerebral palsy	PMID: 18977990
Diabetic nephropathy	PMID: 19690890
Endometriosis	PMID: 9806560
Endometriosis	INFBASE9806560
Preterm delivery	PMID: 17267840

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
9806560	Endometrio sis					u-PA PAI-1 PAI-2	Show abstract