Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 63027
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol SLC22A23   Gene   UCSC   Ensembl
Aliases C6orf85
Gene name solute carrier family 22 member 23
Alternate names solute carrier family 22 member 23, ion transporter protein,
Gene location 6p25.2 (3456573: 3268972)     Exons: 20     NC_000006.12
Gene summary(Entrez) SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]
OMIM 611697

Protein Summary
Protein general information A1A5C7  

Name: Solute carrier family 22 member 23

Length: 686  Mass: 73,748

Sequence MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSL
LLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMG
NWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDN
AWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILT
LYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQ
FESAKRLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFAR
SMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPD
SGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLH
HIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLP
EGATANGMKAM
Structural information
Interpro:  IPR020846 IPR005828 IPR005829
Prosite:   PS50850 PS00216

Pfam:  		 PF00083
CDD:   cd06174
STRING:   ENSP00000385028;
Other Databases GeneCards:  SLC22A23;  Malacards:  SLC22A23

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005515 protein binding
 IPI molecular_function
GO:0005887 integral component of pla
sma membrane
 IBA cellular_component
GO:0008514 organic anion transmembra
ne transporter activity
 IBA molecular_function
GO:0015711 organic anion transport
 IEA biological_process
GO:0055085 transmembrane transport
 IEA biological_process
GO:0005215 transporter activity
 IEA molecular_function
GO:0005515 protein binding
 IPI molecular_function
GO:0005887 integral component of pla
sma membrane
 IBA cellular_component
GO:0006810 transport
 IEA biological_process
GO:0006811 ion transport
 IEA biological_process
GO:0008514 organic anion transmembra
ne transporter activity
 IBA molecular_function
GO:0015711 organic anion transport
 IEA biological_process
GO:0016020 membrane
 IEA cellular_component
GO:0016020 membrane
 IEA cellular_component
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0022857 transmembrane transporter
activity
 IEA molecular_function
GO:0055085 transmembrane transport
 IEA biological_process
GO:0005515 protein binding
 IPI molecular_function
GO:0005887 integral component of pla
sma membrane
 IBA cellular_component
GO:0008514 organic anion transmembra
ne transporter activity
 IBA molecular_function

Diseases

Associated diseases References
Crohn's disease PMID: 19068216
Endometriosis PMID: 20935158
Spermatogenic defects INFBASE20935158
Endometriosis INFBASE20935158

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
20935158 Endometrio
sis
 SLC22A23 (rs14647)

Female infertility PIWIL3/HIWI3
 Show abstract