Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Search Result


Gene id 6578
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol SLCO2A1   Gene   UCSC   Ensembl
Aliases MATR1, OATP2A1, PGT, PHOAR2, SLC21A2
Gene name solute carrier organic anion transporter family member 2A1
Alternate names solute carrier organic anion transporter family member 2A1, matrin F/G 1, solute carrier family 21 (prostaglandin transporter), member 2,
Gene location 3q22.1-q22.2 (134030075: 133932695)     Exons: 16     NC_000003.12
Gene summary(Entrez) This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
OMIM 601460

Protein Summary
Protein general information Q92959  

Name: Solute carrier organic anion transporter family member 2A1 (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2)

Length: 643  Mass: 70,044

Tissue specificity: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart. {ECO

Sequence MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISS
LNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDL
PPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLL
GSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLE
EAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPA
AALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSC
PDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFV
SLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDND
ALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI
Structural information
Protein Domains
 Kazal-like. (438-496)
Interpro:  IPR002350 IPR020846 IPR004156
Prosite:   PS51465 PS50850

Pfam:  		 PF07648 PF03137
CDD:   cd06174

PDB:  		 3MRR
PDBsum:   3MRR
STRING:   ENSP00000311291;
Other Databases GeneCards:  SLCO2A1;  Malacards:  SLCO2A1

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005319 lipid transporter activit
y
 TAS molecular_function
GO:0005886 plasma membrane
 TAS cellular_component
GO:0005887 integral component of pla
sma membrane
 TAS cellular_component
GO:0006869 lipid transport
 TAS biological_process
GO:0015132 prostaglandin transmembra
ne transporter activity
 IBA molecular_function
GO:0015132 prostaglandin transmembra
ne transporter activity
 TAS molecular_function
GO:0015347 sodium-independent organi
c anion transmembrane tra
nsporter activity
 IBA molecular_function
GO:0015732 prostaglandin transport
 IEA biological_process
GO:0016020 membrane
 TAS cellular_component
GO:0043252 sodium-independent organi
c anion transport
 IBA biological_process
GO:0043252 sodium-independent organi
c anion transport
 TAS biological_process
GO:0005215 transporter activity
 IEA molecular_function
GO:0005319 lipid transporter activit
y
 TAS molecular_function
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 TAS cellular_component
GO:0005887 integral component of pla
sma membrane
 TAS cellular_component
GO:0006810 transport
 IEA biological_process
GO:0006810 transport
 IEA biological_process
GO:0006869 lipid transport
 TAS biological_process
GO:0015132 prostaglandin transmembra
ne transporter activity
 IEA molecular_function
GO:0015132 prostaglandin transmembra
ne transporter activity
 IBA molecular_function
GO:0015132 prostaglandin transmembra
ne transporter activity
 TAS molecular_function
GO:0015347 sodium-independent organi
c anion transmembrane tra
nsporter activity
 IBA molecular_function
GO:0015732 prostaglandin transport
 IEA biological_process
GO:0016020 membrane
 IEA cellular_component
GO:0016020 membrane
 IEA cellular_component
GO:0016020 membrane
 TAS cellular_component
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0043252 sodium-independent organi
c anion transport
 IBA biological_process
GO:0043252 sodium-independent organi
c anion transport
 TAS biological_process
GO:0005319 lipid transporter activit
y
 TAS molecular_function
GO:0005886 plasma membrane
 TAS cellular_component
GO:0005887 integral component of pla
sma membrane
 TAS cellular_component
GO:0006869 lipid transport
 TAS biological_process
GO:0015132 prostaglandin transmembra
ne transporter activity
 IBA molecular_function
GO:0015132 prostaglandin transmembra
ne transporter activity
 TAS molecular_function
GO:0015347 sodium-independent organi
c anion transmembrane tra
nsporter activity
 IBA molecular_function
GO:0016020 membrane
 TAS cellular_component
GO:0043252 sodium-independent organi
c anion transport
 IBA biological_process
GO:0043252 sodium-independent organi
c anion transport
 TAS biological_process

Diseases

Associated diseases References
Endometriosis PMID: 26240828
Hyperbilirubinemia PMID: 15864125
Endometriosis INFBASE26240828
Primary hypertrophic osteoarthropathy KEGG: H00457, OMIM: 601460

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
26240828 Endometrio
sis
 108
 108 (78 with en
dometriosis, 30
healthy contro
l subjects)
 Female infertility EP3
EP4
FP
PGT
MRP4
 Show abstract