Endometriosis Knowledgebase

Search Result

Gene id

83716

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

CRISPLD2 Gene UCSC Ensembl

Aliases

CRISP11, LCRISP2, LGL1

Gene name

cysteine rich secretory protein LCCL domain containing 2

Alternate names

cysteine-rich secretory protein LCCL domain-containing 2, CRISP-11, LCCL domain-containing cysteine-rich secretory protein 2, cysteine-rich secretory protein 11, late gestation lung 1, testis secretory sperm-binding protein Li 207a, trypsin inhibitor,

Gene location

16q24.1 (84819980: 84909509) Exons: 16 NC_000016.10

OMIM

612434

Protein Summary

Protein general information

Q9H0B8

Name: Cysteine-rich secretory protein LCCL domain-containing 2 (Cysteine-rich secretory protein 11) (CRISP-11) (LCCL domain-containing cysteine-rich secretory protein 2)

Length: 497 Mass: 55,920

Sequence

MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQAS
NMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWC
PERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSY
GGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKG
STCNRYQCPAGCLNHKAKIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKP
SSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVIS
NESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ

Structural information

Protein Domains	SCP (62-200) LCCL (284-379) LCCL (385-488)
Interpro:	IPR001283 IPR018244 IPR014044 IPR035940 IPR004043 IPR036609
Prosite:	PS01010 PS50820
Pfam:	PF00188 PF03815
STRING:	ENSP00000262424;

Other Databases

GeneCards: CRISPLD2; Malacards: CRISPLD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005578	proteinaceous extracellul ar matrix	IEA	cellular_component
GO:0008201	heparin binding	IEA	molecular_function
GO:0030133	transport vesicle	IDA	cellular_component
GO:0030198	extracellular matrix orga nization	IEA	biological_process
GO:0030324	lung development	IEA	biological_process
GO:0060325	face morphogenesis	IMP	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0005539	glycosaminoglycan binding	IEA	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005578	proteinaceous extracellul ar matrix	IEA	cellular_component
GO:0008201	heparin binding	IEA	molecular_function
GO:0030133	transport vesicle	IDA	cellular_component
GO:0030198	extracellular matrix orga nization	IEA	biological_process
GO:0030324	lung development	IEA	biological_process
GO:0060325	face morphogenesis	IMP	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0030133	transport vesicle	IDA	cellular_component
GO:0060325	face morphogenesis	IMP	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component

Diseases

Associated diseases	References
Diabetes	GAD20536507
Cleft lip with cleft palate	GAD17616516
Endometriosis	PubMed24955763

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
24955763	Endometrio sis						Show abstract