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Gene id

9670

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

IPO13 Gene UCSC Ensembl

Aliases

IMP13, KAP13, LGL2, RANBP13

Gene name

importin 13

Alternate names

importin-13, Ran binding protein 13, karyopherin 13, late gestation lung 2, ran-binding protein 13,

Gene location

1p34.1 (43946805: 43968021) Exons: 21 NC_000001.11

Gene summary(Entrez)

This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]

OMIM

610411

Protein Summary

Protein general information

O94829

Name: Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)

Length: 963 Mass: 108,195

Tissue specificity: Expressed in fetal brain, heart, intestine and kidney. {ECO

Sequence

MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQ
YFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLF
QAEDSPVDGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKC
FSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNG
DMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFE
AEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKL
GRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPV
MINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSA
LQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLPVPQGPN
PVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQL
VHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLA
LKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL
SMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY

Structural information

Protein Domains	Importin (45-111)
Interpro:	IPR011989 IPR016024 IPR013598 IPR001494
Prosite:	PS50166
Pfam:	PF03810 PF08389
PDB:	2X19 2XWU 3ZJY
PDBsum:	2X19 2XWU 3ZJY
MINT:
STRING:	ENSP00000361418;

Other Databases

GeneCards: IPO13; Malacards: IPO13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005737	cytoplasm	IBA	cellular_component
GO:0006606	protein import into nucle us	IDA	biological_process
GO:0008139	nuclear localization sequ ence binding	IBA	molecular_function
GO:0008536	Ran GTPase binding	IEA	molecular_function
GO:0008565	protein transporter activ ity	IBA	molecular_function
GO:0031965	nuclear membrane	IBA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005737	cytoplasm	IBA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006606	protein import into nucle us	IDA	biological_process
GO:0006810	transport	IEA	biological_process
GO:0006886	intracellular protein tra nsport	IEA	biological_process
GO:0008139	nuclear localization sequ ence binding	IBA	molecular_function
GO:0008536	Ran GTPase binding	IEA	molecular_function
GO:0008565	protein transporter activ ity	IBA	molecular_function
GO:0015031	protein transport	IEA	biological_process
GO:0031965	nuclear membrane	IBA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005737	cytoplasm	IBA	cellular_component
GO:0006606	protein import into nucle us	IDA	biological_process
GO:0008139	nuclear localization sequ ence binding	IBA	molecular_function
GO:0008565	protein transporter activ ity	IBA	molecular_function
GO:0031965	nuclear membrane	IBA	cellular_component

Diseases

Associated diseases	References
Asthma	GAD19619331
Endometriosis	PubMed22648251

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
22648251	Endometrio sis						Show abstract