Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 9806
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol SPOCK2   Gene   UCSC   Ensembl
Aliases testican-2
Gene name SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
Alternate names testican-2, SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2,
Gene location 10q22.1 (72089031: 72059033)     Exons: 12     NC_000010.11
Gene summary(Entrez) This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
OMIM 607988

Protein Summary
Protein general information Q92563  

Name: Testican 2 (SPARC/osteonectin, CWCV, and Kazal like domains proteoglycan 2)

Length: 424  Mass: 46,779

Tissue specificity: Highly expressed in brain. Also found in lung and testis. {ECO

Sequence MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNRFRDEVEDDYIKSWED
NQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHRIKQPTVKLHGNKDSICKPCHMAQLASVCGS
DGHTYSSVCKLEQQACLSSKQLAVRCEGPCPCPTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQN
GSASSVAGPASGLDKSLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTA
EWCFCFWREKPPCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQLGLELTGTRTHGSPD
CDDIVGFSGDFGSGVGWEDEEEKETEEAGEEAEEEEGEAGEADDGGYIW
Structural information
Protein Domains
 Kazal-like. (130-182)
Thyroglobulin (310-376)
Interpro:  IPR011992 IPR002350 IPR019577 IPR000716
Prosite:   PS51465 PS00484 PS51162

Pfam:  		 PF07648 PF10591 PF00086
CDD:   cd00252
STRING:   ENSP00000321108;
Other Databases GeneCards:  SPOCK2;  Malacards:  SPOCK2

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005509 calcium ion binding
 IDA molecular_function
GO:0005539 glycosaminoglycan binding
 IEA molecular_function
GO:0005578 proteinaceous extracellul
ar matrix
 NAS cellular_component
GO:0007165 signal transduction
 IEA biological_process
GO:0007416 synapse assembly
 NAS biological_process
GO:0010811 positive regulation of ce
ll-substrate adhesion
 IEA biological_process
GO:0019800 peptide cross-linking via
chondroitin 4-sulfate gl
ycosaminoglycan
 IEA biological_process
GO:0030198 extracellular matrix orga
nization
 NAS biological_process
GO:0045595 regulation of cell differ
entiation
 NAS biological_process
GO:0050840 extracellular matrix bind
ing
 IEA molecular_function
GO:0005509 calcium ion binding
 IEA molecular_function
GO:0005509 calcium ion binding
 IDA molecular_function
GO:0005539 glycosaminoglycan binding
 IEA molecular_function
GO:0005576 extracellular region
 IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
 IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
 IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
 IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
 NAS cellular_component
GO:0007165 signal transduction
 IEA biological_process
GO:0007416 synapse assembly
 NAS biological_process
GO:0010811 positive regulation of ce
ll-substrate adhesion
 IEA biological_process
GO:0019800 peptide cross-linking via
chondroitin 4-sulfate gl
ycosaminoglycan
 IEA biological_process
GO:0030198 extracellular matrix orga
nization
 IEA biological_process
GO:0030198 extracellular matrix orga
nization
 NAS biological_process
GO:0045595 regulation of cell differ
entiation
 NAS biological_process
GO:0050840 extracellular matrix bind
ing
 IEA molecular_function
GO:0005509 calcium ion binding
 IDA molecular_function
GO:0005578 proteinaceous extracellul
ar matrix
 NAS cellular_component
GO:0007416 synapse assembly
 NAS biological_process
GO:0030198 extracellular matrix orga
nization
 NAS biological_process
GO:0045595 regulation of cell differ
entiation
 NAS biological_process

Diseases

Associated diseases References
Endometriosis (ovarian) PMID: 25298284
Endometriosis (ovarian) PMID: 22333230
Endometriosis-associated ovarian carcinoma, Ovarian endometrioid cancer (OEC) and ovarian clear cell cancer (OCCC) INFBASE25298284
Ovarian endometriosis INFBASE25298284
Ovarian endometriosis INFBASE22333230
Ovarian endometriosis PMID: 22333230

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
25298284 Endometrio
sis (ovari
an)
50 (30 EMS-asso
ciated ovarian
carcinoma (18 O
varian endometr
ioid cancer, 12
ovarian clear
cell cancer), 2
0 normal endome
trial specimens
)
 RASSF2
RUNX3
GSTZ1
CYP2A
GBGT1
NDUFS1
SPOCK2
ADAM22
and TRIM36
 Show abstract
22333230 Endometrio
sis (ovari
an)
108 (22 maligna
nt tissues, 15
ectopic endomet
ria and 10 euto
pic endometria
were captured b
y microdissecti
on in EAOC grou
p; 22 ectopic e
ndometria and 1
7 eutopic endom
etria were capt
ured in EM grou
p; 22 endometri
um)
 SPOCK2
 Show abstract