Endometriosis Knowledgebase

PMID	15749523
Gene Name	EGFR
Condition	Endometriosis
Association	Associated
Mutation	EGFR ( 2073*T)
Sex	Female
Associated genes	EGFR
Other associated phenotypes	Endometriosis, leiomyomas
T homozygote and allele of epidermal growth factor receptor 2073 gene polymorphism are associated with higher susceptibility to endometriosis and leiomyomas. Fertil Steril. 2005 Mar;83(3):796-9. Hsieh, Yao-Yuan\| Chang, Chi-Chen\| Tsai, Fuu-Jen\| Lin, Cheng-Chieh\| Tsai, Chang-Hai Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan. Epidermal growth factor receptor (EGFR) is a regulator of angiogenesis and mediator of sex steroid-induced cell growth and differentiation. We observed that EGFR gene 2073T-related genotypes and allele are associated with higher susceptibilities to endometriosis and leiomyoma. Mesh Terms:* Endometriosis/genetics\| Female\| Gene Frequency\| Genetic Predisposition to Disease\| Genotype\| Heterozygote\| Homozygote\| Humans\| Leiomyoma/genetics\| Polymorphism, Genetic\| Receptor, Epidermal Growth Factor/genetics\| Uterine Neoplasms/*genetic