Endometriosis Knowledgebase

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Gene id

10272

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

FSTL3 Gene UCSC Ensembl

Aliases

FLRG, FSRP

Gene name

follistatin like 3

Alternate names

follistatin-related protein 3, follistatin-like 3 (secreted glycoprotein), follistatin-like protein 3, follistatin-related gene protein,

Gene location

19p13.3 (676388: 683391) Exons: 5 NC_000019.10

Gene summary(Entrez)

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]

OMIM

605343

Protein Summary

Protein general information

O95633

Name: Follistatin related protein 3 (Follistatin like protein 3) (Follistatin related gene protein)

Length: 263 Mass: 27,663

Tissue specificity: Expressed in a wide range of tissues. {ECO

Sequence

MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLT
HPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRA
ARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMR
QATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV

Structural information

Protein Domains	TB. (36-107) Follistatin-like (99-119) Kazal-like (113-169) Follistatin-like (170-193) Kazal-like (189-245)
Interpro:	IPR003645 IPR015369 IPR002350 IPR017878
Prosite:	PS51465 PS51364
Pfam:	PF09289 PF07648
PDB:	2KCX 3B4V 3SEK
PDBsum:	2KCX 3B4V 3SEK
STRING:	ENSP00000166139;

Other Databases

GeneCards: FSTL3; Malacards: FSTL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001503	ossification	IEA	biological_process
GO:0001822	kidney development	IEA	biological_process
GO:0001968	fibronectin binding	IPI	molecular_function
GO:0002244	hematopoietic progenitor cell differentiation	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0006351	transcription, DNA-templa ted	IEA	biological_process
GO:0006357	regulation of transcripti on from RNA polymerase II promoter	IDA	biological_process
GO:0007283	spermatogenesis	IEA	biological_process
GO:0008584	male gonad development	IEA	biological_process
GO:0022409	positive regulation of ce ll-cell adhesion	IDA	biological_process
GO:0030141	secretory granule	IEA	cellular_component
GO:0030324	lung development	IEA	biological_process
GO:0030325	adrenal gland development	IEA	biological_process
GO:0030514	negative regulation of BM P signaling pathway	IDA	biological_process
GO:0032926	negative regulation of ac tivin receptor signaling pathway	IDA	biological_process
GO:0032926	negative regulation of ac tivin receptor signaling pathway	IDA	biological_process
GO:0044306	neuron projection terminu s	IEA	cellular_component
GO:0045671	negative regulation of os teoclast differentiation	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0048185	activin binding	IPI	molecular_function
GO:0071248	cellular response to meta l ion	IEA	biological_process
GO:0090101	negative regulation of tr ansmembrane receptor prot ein serine/threonine kina se signaling pathway	IDA	biological_process
GO:0001503	ossification	IEA	biological_process
GO:0001822	kidney development	IEA	biological_process
GO:0001968	fibronectin binding	IPI	molecular_function
GO:0002244	hematopoietic progenitor cell differentiation	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0006351	transcription, DNA-templa ted	IEA	biological_process
GO:0006355	regulation of transcripti on, DNA-templated	IEA	biological_process
GO:0006357	regulation of transcripti on from RNA polymerase II promoter	IDA	biological_process
GO:0007283	spermatogenesis	IEA	biological_process
GO:0008584	male gonad development	IEA	biological_process
GO:0022409	positive regulation of ce ll-cell adhesion	IDA	biological_process
GO:0030141	secretory granule	IEA	cellular_component
GO:0030324	lung development	IEA	biological_process
GO:0030325	adrenal gland development	IEA	biological_process
GO:0030514	negative regulation of BM P signaling pathway	IEA	biological_process
GO:0030514	negative regulation of BM P signaling pathway	IDA	biological_process
GO:0032926	negative regulation of ac tivin receptor signaling pathway	IDA	biological_process
GO:0032926	negative regulation of ac tivin receptor signaling pathway	IDA	biological_process
GO:0044306	neuron projection terminu s	IEA	cellular_component
GO:0045671	negative regulation of os teoclast differentiation	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0048185	activin binding	IEA	molecular_function
GO:0048185	activin binding	IPI	molecular_function
GO:0071248	cellular response to meta l ion	IEA	biological_process
GO:0090101	negative regulation of tr ansmembrane receptor prot ein serine/threonine kina se signaling pathway	IDA	biological_process
GO:0001968	fibronectin binding	IPI	molecular_function
GO:0002244	hematopoietic progenitor cell differentiation	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0006357	regulation of transcripti on from RNA polymerase II promoter	IDA	biological_process
GO:0022409	positive regulation of ce ll-cell adhesion	IDA	biological_process
GO:0030514	negative regulation of BM P signaling pathway	IDA	biological_process
GO:0032926	negative regulation of ac tivin receptor signaling pathway	IDA	biological_process
GO:0032926	negative regulation of ac tivin receptor signaling pathway	IDA	biological_process
GO:0045671	negative regulation of os teoclast differentiation	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0048185	activin binding	IPI	molecular_function
GO:0090101	negative regulation of tr ansmembrane receptor prot ein serine/threonine kina se signaling pathway	IDA	biological_process

Diseases

Associated diseases	References
Endometriosis (ovarian)	PMID: 17296189
Diminished ovarian reserve (DOR)	PMID: 22246450
Ovarian endometriosis	PMID: 17296189
Ovarian endometriosis	PMID: 17296189
Polycystic ovary syndrome (PCOS)	PMID: 16817091
Premature ovarian failure ( POF)	PMID: 16817091
Ovarian endometriosis	INFBASE17296189

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
17296189	Endometrio sis (ovari an)			34 (16 ovarian endometriotic c ysts, 18 contro ls)		FLRG	Show abstract