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Gene id

10298

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

PAK4 Gene UCSC Ensembl

Gene name

p21 (RAC1) activated kinase 4

Alternate names

serine/threonine-protein kinase PAK 4, p21 protein (Cdc42/Rac)-activated kinase 4, p21(CDKN1A)-activated kinase 4, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs,

Gene location

19q13.2 (39125779: 39179405) Exons: 14 NC_000019.10

Gene summary(Entrez)

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OMIM

605451

Protein Summary

Protein general information

O96013

Name: Serine/threonine protein kinase PAK 4 (EC 2.7.11.1) (p21 activated kinase 4) (PAK 4)

Length: 591 Mass: 64,072

Tissue specificity: Highest expression in prostate, testis and colon.

Sequence

MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSK
GAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGD
RRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPH
DVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH
ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH
DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMK
MIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR

Structural information

Protein Domains	CRIB. (11-24) Protein (321-572)
Interpro:	IPR000095 IPR011009 IPR033923 IPR000719 IPR017441
Prosite:	PS50108 PS00107 PS50011
Pfam:	PF00786 PF00069
CDD:	cd01093
PDB:	2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B
PDBsum:	2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B
DIP:	39742
MINT:	1387795
STRING:	ENSP00000351049;

Other Databases

GeneCards: PAK4; Malacards: PAK4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004672	protein kinase activity	NAS	molecular_function
GO:0004702	signal transducer, downst ream of receptor, with se rine/threonine kinase act ivity	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0005925	focal adhesion	IDA	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0007010	cytoskeleton organization	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0016049	cell growth	TAS	biological_process
GO:0016477	cell migration	TAS	biological_process
GO:0023014	signal transduction by pr otein phosphorylation	IEA	biological_process
GO:0060996	dendritic spine developme nt	IEA	biological_process
GO:0071407	cellular response to orga nic cyclic compound	IEA	biological_process
GO:0000278	mitotic cell cycle	IBA	biological_process
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0004672	protein kinase activity	NAS	molecular_function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0004702	signal transducer, downst ream of receptor, with se rine/threonine kinase act ivity	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0005925	focal adhesion	IDA	cellular_component
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0006915	apoptotic process	IEA	biological_process
GO:0006915	apoptotic process	TAS	biological_process
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0007010	cytoskeleton organization	TAS	biological_process
GO:0007049	cell cycle	IEA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0016049	cell growth	TAS	biological_process
GO:0016301	kinase activity	IEA	molecular_function
GO:0016310	phosphorylation	IEA	biological_process
GO:0016477	cell migration	TAS	biological_process
GO:0016740	transferase activity	IEA	molecular_function
GO:0023014	signal transduction by pr otein phosphorylation	IEA	biological_process
GO:0060996	dendritic spine developme nt	IEA	biological_process
GO:0071407	cellular response to orga nic cyclic compound	IEA	biological_process
GO:0000278	mitotic cell cycle	IBA	biological_process
GO:0004672	protein kinase activity	NAS	molecular_function
GO:0004702	signal transducer, downst ream of receptor, with se rine/threonine kinase act ivity	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0005925	focal adhesion	IDA	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0007010	cytoskeleton organization	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0016049	cell growth	TAS	biological_process
GO:0016477	cell migration	TAS	biological_process
GO:0000278	mitotic cell cycle	IBA	biological_process

KEGG pathways

hsa05206  MicroRNAs in cancer
hsa04014  Ras signaling pathway
hsa04510  Focal adhesion
hsa04810  Regulation of actin cytoskeleton
hsa04360  Axon guidance
hsa04660  T cell receptor signaling pathway
hsa04012  ErbB signaling pathway
hsa05211  Renal cell carcinoma

Diseases

Associated diseases	References
Endometriosis	PMID: 23293332
Endometriosis	INFBASE23293332
Parkinson's disease	PMID: 18628988

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
23293332	Endometrio sis			72 (38 women wi th endometriosi s, 34 women wit h carcinoma in situ of the ute rine cervix as controls)		TNF PAK4	Show abstract