Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 10563
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol CXCL13   Gene   UCSC   Ensembl
Aliases ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13
Gene name C-X-C motif chemokine ligand 13
Alternate names C-X-C motif chemokine 13, B-cell chemoattractant, B-cell-attracting chemokine 1, B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1), B-lymphocyte chemoattractant, CXC chemokine BLC, b cell-attracting chemokine 1, b lymphocyte chemoattractant, chem,
Gene location 4q21.1 (77511752: 77611833)     Exons: 5     NC_000004.12
Gene summary(Entrez) B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
OMIM 605149

Protein Summary

Protein general information O43927  

Name: C X C motif chemokine 13 (Angie) (B cell attracting chemokine 1) (BCA 1) (B lymphocyte chemoattractant) (CXC chemokine BLC) (Small inducible cytokine B13)

Length: 109  Mass: 12,664

Tissue specificity: Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

Sequence MKFISTSLLLMLLVSSLSPVQGVLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNKSIV
CVDPQAEWIQRMMEVLRKRSSSTLPVPVFKRKIP
Structural information
Interpro:  IPR001089 IPR018048 IPR001811 IPR033899
Prosite:   PS00471

Pfam:  
PF00048
CDD:   cd00273

PDB:  
4ZAI 5CBA 5CBE
PDBsum:   4ZAI 5CBA 5CBE

DIP:  
5914
MINT:   123997
STRING:   ENSP00000286758;
Other Databases GeneCards:  CXCL13;  Malacards:  CXCL13

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0002467 germinal center formation
NAS biological_process
GO:0002518 lymphocyte chemotaxis acr
oss high endothelial venu
le
ISS biological_process
GO:0002544 chronic inflammatory resp
onse
NAS biological_process
GO:0002920 regulation of humoral imm
une response
NAS biological_process
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0005623 cell
IEA cellular_component
GO:0006954 inflammatory response
IBA biological_process
GO:0006955 immune response
IBA biological_process
GO:0006955 immune response
IC biological_process
GO:0007166 cell surface receptor sig
naling pathway
IDA biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0007204 positive regulation of cy
tosolic calcium ion conce
ntration
IDA biological_process
GO:0007267 cell-cell signaling
IDA biological_process
GO:0008009 chemokine activity
IDA molecular_function
GO:0008201 heparin binding
IDA molecular_function
GO:0010820 positive regulation of T
cell chemotaxis
IDA biological_process
GO:0017134 fibroblast growth factor
binding
IDA molecular_function
GO:0031724 CXCR5 chemokine receptor
binding
IDA molecular_function
GO:0031735 CCR10 chemokine receptor
binding
IDA molecular_function
GO:0032496 response to lipopolysacch
aride
IBA biological_process
GO:0033625 positive regulation of in
tegrin activation
ISS biological_process
GO:0033634 positive regulation of ce
ll-cell adhesion mediated
by integrin
ISS biological_process
GO:0035754 B cell chemotaxis
IDA biological_process
GO:0035768 endothelial cell chemotax
is to fibroblast growth f
actor
IDA biological_process
GO:0035769 B cell chemotaxis across
high endothelial venule
IEA biological_process
GO:0042127 regulation of cell prolif
eration
IBA biological_process
GO:0042742 defense response to bacte
rium
IDA biological_process
GO:0045765 regulation of angiogenesi
s
NAS biological_process
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0048018 receptor agonist activity
IDA molecular_function
GO:0048248 CXCR3 chemokine receptor
binding
IPI molecular_function
GO:0048535 lymph node development
IEA biological_process
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0090630 activation of GTPase acti
vity
ISS biological_process
GO:2000545 negative regulation of en
dothelial cell chemotaxis
to fibroblast growth fac
tor
IDA biological_process
GO:0002467 germinal center formation
NAS biological_process
GO:0002518 lymphocyte chemotaxis acr
oss high endothelial venu
le
IEA biological_process
GO:0002518 lymphocyte chemotaxis acr
oss high endothelial venu
le
ISS biological_process
GO:0002544 chronic inflammatory resp
onse
NAS biological_process
GO:0002920 regulation of humoral imm
une response
NAS biological_process
GO:0005125 cytokine activity
IEA molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005623 cell
IEA cellular_component
GO:0006935 chemotaxis
IEA biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0006954 inflammatory response
IEA biological_process
GO:0006955 immune response
IEA biological_process
GO:0006955 immune response
IBA biological_process
GO:0006955 immune response
IC biological_process
GO:0007166 cell surface receptor sig
naling pathway
IDA biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0007204 positive regulation of cy
tosolic calcium ion conce
ntration
IDA biological_process
GO:0007267 cell-cell signaling
IDA biological_process
GO:0008009 chemokine activity
IEA molecular_function
GO:0008009 chemokine activity
IEA molecular_function
GO:0008009 chemokine activity
IDA molecular_function
GO:0008201 heparin binding
IDA molecular_function
GO:0010820 positive regulation of T
cell chemotaxis
IDA biological_process
GO:0017134 fibroblast growth factor
binding
IDA molecular_function
GO:0031724 CXCR5 chemokine receptor
binding
IEA molecular_function
GO:0031724 CXCR5 chemokine receptor
binding
IDA molecular_function
GO:0031735 CCR10 chemokine receptor
binding
IDA molecular_function
GO:0032496 response to lipopolysacch
aride
IBA biological_process
GO:0033625 positive regulation of in
tegrin activation
IEA biological_process
GO:0033625 positive regulation of in
tegrin activation
ISS biological_process
GO:0033634 positive regulation of ce
ll-cell adhesion mediated
by integrin
IEA biological_process
GO:0033634 positive regulation of ce
ll-cell adhesion mediated
by integrin
ISS biological_process
GO:0035754 B cell chemotaxis
IEA biological_process
GO:0035754 B cell chemotaxis
IDA biological_process
GO:0035768 endothelial cell chemotax
is to fibroblast growth f
actor
IDA biological_process
GO:0035769 B cell chemotaxis across
high endothelial venule
IEA biological_process
GO:0042127 regulation of cell prolif
eration
IBA biological_process
GO:0042742 defense response to bacte
rium
IDA biological_process
GO:0045765 regulation of angiogenesi
s
NAS biological_process
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0048018 receptor agonist activity
IDA molecular_function
GO:0048248 CXCR3 chemokine receptor
binding
IPI molecular_function
GO:0048535 lymph node development
IEA biological_process
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0090630 activation of GTPase acti
vity
IEA biological_process
GO:0090630 activation of GTPase acti
vity
ISS biological_process
GO:2000545 negative regulation of en
dothelial cell chemotaxis
to fibroblast growth fac
tor
IDA biological_process
GO:0002467 germinal center formation
NAS biological_process
GO:0002518 lymphocyte chemotaxis acr
oss high endothelial venu
le
ISS biological_process
GO:0002544 chronic inflammatory resp
onse
NAS biological_process
GO:0002920 regulation of humoral imm
une response
NAS biological_process
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0006954 inflammatory response
IBA biological_process
GO:0006955 immune response
IBA biological_process
GO:0006955 immune response
IC biological_process
GO:0007166 cell surface receptor sig
naling pathway
IDA biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0007204 positive regulation of cy
tosolic calcium ion conce
ntration
IDA biological_process
GO:0007267 cell-cell signaling
IDA biological_process
GO:0008009 chemokine activity
IDA molecular_function
GO:0008201 heparin binding
IDA molecular_function
GO:0010820 positive regulation of T
cell chemotaxis
IDA biological_process
GO:0017134 fibroblast growth factor
binding
IDA molecular_function
GO:0031724 CXCR5 chemokine receptor
binding
IDA molecular_function
GO:0031735 CCR10 chemokine receptor
binding
IDA molecular_function
GO:0032496 response to lipopolysacch
aride
IBA biological_process
GO:0033625 positive regulation of in
tegrin activation
ISS biological_process
GO:0033634 positive regulation of ce
ll-cell adhesion mediated
by integrin
ISS biological_process
GO:0035754 B cell chemotaxis
IDA biological_process
GO:0035768 endothelial cell chemotax
is to fibroblast growth f
actor
IDA biological_process
GO:0042127 regulation of cell prolif
eration
IBA biological_process
GO:0042742 defense response to bacte
rium
IDA biological_process
GO:0045765 regulation of angiogenesi
s
NAS biological_process
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0048018 receptor agonist activity
IDA molecular_function
GO:0048248 CXCR3 chemokine receptor
binding
IPI molecular_function
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0090630 activation of GTPase acti
vity
ISS biological_process
GO:2000545 negative regulation of en
dothelial cell chemotaxis
to fibroblast growth fac
tor
IDA biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway

Diseases

Associated diseases References
Endometriosis PMID: 25031316
Endometriosis INFBASE24292148

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
25031316 Endometrio
sis

77 (50 controls
, 27 unexplaine
d infertility c
ases with endom
etriosis)
Female infertility
Show abstract
24292148 Endometrio
sis

47 (Microarray
study: 10 infer
tile women with
endometriosis,
5 fertile cont
rols; qRT-PCR (
27 infertile wo
men with endome
triosis, 15 fer
tile controls))

Show abstract