Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Search Result


Gene id 11040
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol PIM2   Gene   UCSC   Ensembl
Gene name Pim-2 proto-oncogene, serine/threonine kinase
Alternate names serine/threonine-protein kinase pim-2, pim-2 oncogene, pim-2h, proto-oncogene Pim-2 (serine threonine kinase),
Gene location Xp11.23 (48919135: 48913181)     Exons: 6     NC_000023.11
Gene summary(Entrez) This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]
OMIM 300295

Protein Summary

Protein general information Q9P1W9  

Name: Serine/threonine protein kinase pim 2 (EC 2.7.11.1) (Pim 2h)

Length: 311  Mass: 34,190

Tissue specificity: Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tiss

Sequence MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLS
DSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA
IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLG
ILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
Structural information
Protein Domains
Protein (32-286)
Interpro:  IPR011009 IPR017348 IPR000719 IPR017441 IPR008271
Prosite:   PS00107 PS50011 PS00108

Pfam:  
PF00069

PDB:  
2IWI 4X7Q
PDBsum:   2IWI 4X7Q
MINT:   1432143
STRING:   ENSP00000365692;
Other Databases GeneCards:  PIM2;  Malacards:  PIM2

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0000082 G1/S transition of mitoti
c cell cycle
IDA biological_process
GO:0004674 protein serine/threonine
kinase activity
IDA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005737 cytoplasm
IBA cellular_component
GO:0006468 protein phosphorylation
ISS biological_process
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006915 apoptotic process
IEA biological_process
GO:0007140 male meiosis
TAS biological_process
GO:0007346 regulation of mitotic cel
l cycle
IBA biological_process
GO:0008283 cell proliferation
TAS biological_process
GO:0008285 negative regulation of ce
ll proliferation
IDA biological_process
GO:0009615 response to virus
IEP biological_process
GO:0010508 positive regulation of au
tophagy
ISS biological_process
GO:0043066 negative regulation of ap
optotic process
IDA biological_process
GO:0043123 positive regulation of I-
kappaB kinase/NF-kappaB s
ignaling
ISS biological_process
GO:0045893 positive regulation of tr
anscription, DNA-template
d
ISS biological_process
GO:0046777 protein autophosphorylati
on
IBA biological_process
GO:0050821 protein stabilization
ISS biological_process
GO:0050821 protein stabilization
IMP biological_process
GO:0000082 G1/S transition of mitoti
c cell cycle
IDA biological_process
GO:0000166 nucleotide binding
IEA molecular_function
GO:0004672 protein kinase activity
IEA molecular_function
GO:0004674 protein serine/threonine
kinase activity
IEA molecular_function
GO:0004674 protein serine/threonine
kinase activity
IEA molecular_function
GO:0004674 protein serine/threonine
kinase activity
IDA molecular_function
GO:0004674 protein serine/threonine
kinase activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005737 cytoplasm
IBA cellular_component
GO:0006468 protein phosphorylation
IEA biological_process
GO:0006468 protein phosphorylation
ISS biological_process
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006468 protein phosphorylation
TAS biological_process
GO:0006915 apoptotic process
IEA biological_process
GO:0007049 cell cycle
IEA biological_process
GO:0007140 male meiosis
TAS biological_process
GO:0007346 regulation of mitotic cel
l cycle
IBA biological_process
GO:0008283 cell proliferation
TAS biological_process
GO:0008285 negative regulation of ce
ll proliferation
IDA biological_process
GO:0009615 response to virus
IEP biological_process
GO:0010508 positive regulation of au
tophagy
ISS biological_process
GO:0016301 kinase activity
IEA molecular_function
GO:0016310 phosphorylation
IEA biological_process
GO:0016740 transferase activity
IEA molecular_function
GO:0043066 negative regulation of ap
optotic process
IEA biological_process
GO:0043066 negative regulation of ap
optotic process
IDA biological_process
GO:0043123 positive regulation of I-
kappaB kinase/NF-kappaB s
ignaling
ISS biological_process
GO:0045893 positive regulation of tr
anscription, DNA-template
d
ISS biological_process
GO:0046777 protein autophosphorylati
on
IBA biological_process
GO:0050821 protein stabilization
ISS biological_process
GO:0050821 protein stabilization
IMP biological_process
GO:0000082 G1/S transition of mitoti
c cell cycle
IDA biological_process
GO:0004674 protein serine/threonine
kinase activity
IDA molecular_function
GO:0004674 protein serine/threonine
kinase activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005737 cytoplasm
IBA cellular_component
GO:0006468 protein phosphorylation
ISS biological_process
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006468 protein phosphorylation
TAS biological_process
GO:0007140 male meiosis
TAS biological_process
GO:0007346 regulation of mitotic cel
l cycle
IBA biological_process
GO:0008283 cell proliferation
TAS biological_process
GO:0008285 negative regulation of ce
ll proliferation
IDA biological_process
GO:0009615 response to virus
IEP biological_process
GO:0010508 positive regulation of au
tophagy
ISS biological_process
GO:0043066 negative regulation of ap
optotic process
IDA biological_process
GO:0043123 positive regulation of I-
kappaB kinase/NF-kappaB s
ignaling
ISS biological_process
GO:0045893 positive regulation of tr
anscription, DNA-template
d
ISS biological_process
GO:0046777 protein autophosphorylati
on
IBA biological_process
GO:0050821 protein stabilization
ISS biological_process
GO:0050821 protein stabilization
IMP biological_process

KEGG pathways

hsa05221  Acute myeloid leukemia

Diseases

Associated diseases References
Endometriosis PMID: 16249290
Endometriosis INFBASE16249290

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
16249290 Endometrio
sis

30 (15 patients
undergoing lap
aroscopy or hys
terectomy for e
ndometriosis, 1
5 controls)
IGFBP5
PIM2
RPL41
PSAP
FBLN1
SIPL
DLX5
HSD11B2
SET
and RHOE
Show abstract