Endometriosis Knowledgebase

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Gene id

1116

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

CHI3L1 Gene UCSC Ensembl

Aliases

ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39

Gene name

chitinase 3 like 1

Alternate names

chitinase-3-like protein 1, 39 kDa synovial protein, cartilage glycoprotein 39, chitinase 3-like 1 (cartilage glycoprotein-39),

Gene location

1q32.1 (203186793: 203178930) Exons: 10 NC_000001.11

Gene summary(Entrez)

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

OMIM

601525

Protein Summary

Protein general information

P36222

Name: Chitinase 3 like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP 39) (GP 39) (hCGP 39) (YKL 40)

Length: 383 Mass: 42,625

Tissue specificity: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibrobla

Sequence

MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVT
LYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHF
TTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRG
QEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEIC
DFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNA
IKDALAAT

Structural information

Interpro:	IPR028538 IPR011583 IPR029070 IPR001223 IPR017853
Pfam:	PF00704
PDB:	1HJV 1HJW 1HJX 1LA7 1NWR 1NWS 1NWT 1NWU
PDBsum:	1HJV 1HJW 1HJX 1LA7 1NWR 1NWS 1NWT 1NWU
STRING:	ENSP00000255409;

Other Databases

GeneCards: CHI3L1; Malacards: CHI3L1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005201	extracellular matrix stru ctural constituent	NAS	molecular_function
GO:0005578	proteinaceous extracellul ar matrix	NAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005737	cytoplasm	ISS	cellular_component
GO:0005783	endoplasmic reticulum	ISS	cellular_component
GO:0005975	carbohydrate metabolic pr ocess	IEA	biological_process
GO:0006915	apoptotic process	IEA	biological_process
GO:0006954	inflammatory response	IEP	biological_process
GO:0007250	activation of NF-kappaB-i nducing kinase activity	ISS	biological_process
GO:0008061	chitin binding	IDA	molecular_function
GO:0008061	chitin binding	IDA	molecular_function
GO:0009612	response to mechanical st imulus	IEP	biological_process
GO:0010800	positive regulation of pe ptidyl-threonine phosphor ylation	ISS	biological_process
GO:0030246	carbohydrate binding	IEA	molecular_function
GO:0030324	lung development	IMP	biological_process
GO:0034612	response to tumor necrosi s factor	IEP	biological_process
GO:0045766	positive regulation of an giogenesis	IMP	biological_process
GO:0048471	perinuclear region of cyt oplasm	IEA	cellular_component
GO:0051216	cartilage development	NAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0070555	response to interleukin-1	IEP	biological_process
GO:0070741	response to interleukin-6	IEP	biological_process
GO:0071347	cellular response to inte rleukin-1	IEA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	ISS	biological_process
GO:0072606	interleukin-8 secretion	ISS	biological_process
GO:0004568	chitinase activity	IDA	molecular_function
GO:0004568	chitinase activity	IDA	molecular_function
GO:0006032	chitin catabolic process	IBA	biological_process
GO:0004553	hydrolase activity, hydro lyzing O-glycosyl compoun ds	IEA	molecular_function
GO:0005201	extracellular matrix stru ctural constituent	NAS	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005578	proteinaceous extracellul ar matrix	NAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	ISS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005783	endoplasmic reticulum	ISS	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005975	carbohydrate metabolic pr ocess	IEA	biological_process
GO:0006915	apoptotic process	IEA	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	IEP	biological_process
GO:0007250	activation of NF-kappaB-i nducing kinase activity	IEA	biological_process
GO:0007250	activation of NF-kappaB-i nducing kinase activity	ISS	biological_process
GO:0008061	chitin binding	IEA	molecular_function
GO:0008061	chitin binding	IDA	molecular_function
GO:0008061	chitin binding	IDA	molecular_function
GO:0009612	response to mechanical st imulus	IEP	biological_process
GO:0010800	positive regulation of pe ptidyl-threonine phosphor ylation	IEA	biological_process
GO:0010800	positive regulation of pe ptidyl-threonine phosphor ylation	ISS	biological_process
GO:0030246	carbohydrate binding	IEA	molecular_function
GO:0030324	lung development	IMP	biological_process
GO:0034612	response to tumor necrosi s factor	IEP	biological_process
GO:0045766	positive regulation of an giogenesis	IEA	biological_process
GO:0045766	positive regulation of an giogenesis	IMP	biological_process
GO:0048471	perinuclear region of cyt oplasm	IEA	cellular_component
GO:0051216	cartilage development	NAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IEA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0070555	response to interleukin-1	IEP	biological_process
GO:0070741	response to interleukin-6	IEP	biological_process
GO:0071347	cellular response to inte rleukin-1	IEA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IEA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	ISS	biological_process
GO:0072606	interleukin-8 secretion	IEA	biological_process
GO:0072606	interleukin-8 secretion	ISS	biological_process
GO:0004568	chitinase activity	IDA	molecular_function
GO:0004568	chitinase activity	IDA	molecular_function
GO:0006032	chitin catabolic process	IBA	biological_process
GO:0005201	extracellular matrix stru ctural constituent	NAS	molecular_function
GO:0005578	proteinaceous extracellul ar matrix	NAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005737	cytoplasm	ISS	cellular_component
GO:0005783	endoplasmic reticulum	ISS	cellular_component
GO:0006954	inflammatory response	IEP	biological_process
GO:0007250	activation of NF-kappaB-i nducing kinase activity	ISS	biological_process
GO:0008061	chitin binding	IDA	molecular_function
GO:0008061	chitin binding	IDA	molecular_function
GO:0009612	response to mechanical st imulus	IEP	biological_process
GO:0010800	positive regulation of pe ptidyl-threonine phosphor ylation	ISS	biological_process
GO:0030324	lung development	IMP	biological_process
GO:0034612	response to tumor necrosi s factor	IEP	biological_process
GO:0045766	positive regulation of an giogenesis	IMP	biological_process
GO:0051216	cartilage development	NAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0070555	response to interleukin-1	IEP	biological_process
GO:0070741	response to interleukin-6	IEP	biological_process
GO:0071356	cellular response to tumo r necrosis factor	ISS	biological_process
GO:0072606	interleukin-8 secretion	ISS	biological_process
GO:0004568	chitinase activity	IDA	molecular_function
GO:0004568	chitinase activity	IDA	molecular_function
GO:0006032	chitin catabolic process	IBA	biological_process

Diseases

Associated diseases	References
Asthma	PMID: 19264973
Cancer	PMID: 19255724
Diabetes	PMID: 19421404
Endometrial cancer	PMID: 28624692
Endometriosis	PMID: 24533749
Hypersensitivity	PMID: 19106306
Hypertension	PMID: 19536175
Peritoneal endometriosis	PMID: 19701838
Polycystic ovary syndrome (PCOS)	PMID: 24471491
Sarcoidosis	PMID: 17236752
Schizophrenia	PMID: 17160890
Endometriosis	INFBASE24533749
Peritoneal endometriosis	INFBASE19701838

PubMed references

PMID	Condition	Population details	Associated_genes	Abstract
24533749	Endometrio sis	88 (53 patients with surgicall y proven endome triosis were in cluded, 35 pati ents without en dometriosis com prised the cont rol group)		Show abstract
26411218	Endometrio sis	63 (33 endometr iosis patients, 30 healthy con trols)		Show abstract
19701838	Endometrio sis (Perit oneal)	27 patients who se pathologic r eports indicate d invasion of t he peritoneum b y endometriosis	YKL-40	Show abstract