Search Result
| Gene id | 115352 | ||||||||||||||||||||||||||||||||||||||||||||||||
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| Gene Summary SNPs Protein Summary Gene ontology KEGG pathways Diseases PubMed references | |||||||||||||||||||||||||||||||||||||||||||||||||
Gene Summary |
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| Gene Symbol | FCRL3 Gene UCSC Ensembl | ||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CD307c, FCRH3, IFGP3, IRTA3, SPAP2 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Gene name | Fc receptor like 3 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Alternate names | Fc receptor-like protein 3, Fc receptor homolog 3, IFGP family protein 3, SH2 domain-containing phosphatase anchor protein 2, fcR-like protein 3, hIFGP3, immune receptor translocation-associated protein 3, immunoglobulin superfamily receptor translocation associ, | ||||||||||||||||||||||||||||||||||||||||||||||||
| Gene location |
1q23.1 (157700984: 157676480) Exons: 16 NC_000001.11 |
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| Gene summary(Entrez) |
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
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| OMIM | 606510 | ||||||||||||||||||||||||||||||||||||||||||||||||
SNPs |
rs11264799 Strand: Allele origin: Allele change: C/T Mutation type: snp CM000663.2 g.157700967C>T NC_000001.10 g.157670757C>T NC_000001.11 g.157700967C>T NG_023241.1 g.4891G>A NM_001320333.1 c.-402G>A NM_052939.3 c.-402G>A NR_135214.1 n.-95G>A NR_135215.1 n.-95G>A NR_135216.1 n.-95G>A NR_135217.1 n.-95G>A XR_241064.1 n.-204G>A XR_241065.1 n.-204G>A XR_241066.1 n.-204G>A rs945635 Strand: + Allele origin: unknown Allele change: A/C/G Mutation type: snp XM_006711145.1 c.-11G>C XM_006711145.1 c.-11G>T NM_001320333.1 c.-11G>C NM_001320333.1 c.-11G>T XM_005244872.1 c.-11G>C XM_005244872.1 c.-11G>T XM_005244870.1 c.-11G>C XM_005244870.1 c.-11G>T XM_005244871.1 c.-11G>C XM_005244871.1 c.-11G>T NR_135214.1 n. rs3761959 Strand: - Allele origin: unknown Allele change: A/G Mutation type: snp NC_000001.10 g.157669278C>T NC_000001.11 g.157699488C>T NG_023241.1 g.6370G>A NM_001320333.1 c.52+204G>A NM_052939.3 c.52+204G>A NR_135217.1 n.359+204G>A NR_135216.1 n.359+204G>A NR_135215.1 n.359+204G>A NR_135214.1 n.359+204G>A XM_005244872.1 c.52+204G> rs7528684 Strand: + Allele origin: unknown Allele change: A/G Mutation type: snp NC_000001.10 g.157670816A>G NC_000001.11 g.157701026A>G NG_023241.1 g.4832T>C NM_001320333.1 c.-461T>C NM_052939.3 c.-461T>C NR_135216.1 n.-154T>C NR_135215.1 n.-154T>C NR_135217.1 n.-154T>C NR_135214.1 n.-154T>C XM_005244871.1 c.-263T>C XM_005244872.1 c |
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Protein Summary |
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| Protein general information | Q96P31 Name: Fc receptor like protein 3 (FcR like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation associated protein 3) (SH2 domain containing phosphatase anchor protein 2) (CD antigen CD307c) Length: 734 Mass: 80,856 Tissue specificity: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels | ||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence |
MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQIT EPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKIT VNSVSRDNSKYHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQ FSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLI EGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVT VRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYS CDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSG GGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSILVLAAAAALLHYARAR RKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNPIYSQIWSIQHTKENS ANCPMMHQEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEENYENVPRVLLASDH | ||||||||||||||||||||||||||||||||||||||||||||||||
| Structural information |
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| Other Databases | GeneCards: FCRL3; Malacards: FCRL3 | ||||||||||||||||||||||||||||||||||||||||||||||||
Gene ontology |
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Diseases
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PubMed references |
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