Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 130367
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol SGPP2   Gene   UCSC   Ensembl
Aliases SPP2, SPPase2
Gene name sphingosine-1-phosphate phosphatase 2
Alternate names sphingosine-1-phosphate phosphatase 2, sphingosine 1-phosphate phosphohydrolase 2, sphingosine-1-phosphatase 2, sphingosine-1-phosphate phosphotase 2,
Gene location 2q36.1 (222424051: 222562621)     Exons: 7     NC_000002.12
Gene summary(Entrez) The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
OMIM 612827

Protein Summary

Protein general information Q8IWX5  

Name: Sphingosine-1-phosphate phosphatase 2 (SPPase2) (Spp2) (hSPP2) (EC 3.1.3.-) (Sphingosine-1-phosphatase 2)

Length: 399  Mass: 44,741

Tissue specificity: Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. {ECO

Sequence MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEAY
VQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVV
KLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLIT
ALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLV
SKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKF
VTYTSVGICATTFVPMLHRFLGLP
Structural information
Interpro:  IPR036938 IPR000326

Pfam:  
PF01569
STRING:   ENSP00000315137;
Other Databases GeneCards:  SGPP2;  Malacards:  SGPP2

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006670 sphingosine metabolic pro
cess
IDA biological_process
GO:0016021 integral component of mem
brane
IEA cellular_component
GO:0016311 dephosphorylation
IEA biological_process
GO:0030148 sphingolipid biosynthetic
process
TAS biological_process
GO:0042392 sphingosine-1-phosphate p
hosphatase activity
IDA molecular_function
GO:0042392 sphingosine-1-phosphate p
hosphatase activity
TAS molecular_function
GO:0070780 dihydrosphingosine-1-phos
phate phosphatase activit
y
TAS molecular_function
GO:0005783 endoplasmic reticulum
IEA cellular_component
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
IEA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006670 sphingosine metabolic pro
cess
IDA biological_process
GO:0016020 membrane
IEA cellular_component
GO:0016021 integral component of mem
brane
IEA cellular_component
GO:0016311 dephosphorylation
IEA biological_process
GO:0016787 hydrolase activity
IEA molecular_function
GO:0030148 sphingolipid biosynthetic
process
TAS biological_process
GO:0042392 sphingosine-1-phosphate p
hosphatase activity
IDA molecular_function
GO:0042392 sphingosine-1-phosphate p
hosphatase activity
TAS molecular_function
GO:0070780 dihydrosphingosine-1-phos
phate phosphatase activit
y
TAS molecular_function
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006670 sphingosine metabolic pro
cess
IDA biological_process
GO:0030148 sphingolipid biosynthetic
process
TAS biological_process
GO:0042392 sphingosine-1-phosphate p
hosphatase activity
IDA molecular_function
GO:0042392 sphingosine-1-phosphate p
hosphatase activity
TAS molecular_function
GO:0070780 dihydrosphingosine-1-phos
phate phosphatase activit
y
TAS molecular_function

KEGG pathways

hsa04071  Sphingolipid signaling pathway
hsa00600  Sphingolipid metabolism

Diseases

Associated diseases References
Endometriosis PubMed22277765

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
22277765 Endometrio
sis

47 (15 disease-
free women, 16
eutopic endomet
rium of endomet
riosis-affected
women, 16 ecto
pic endometrium
of endometrios
is-affected wom
en)

Show abstract