Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 1462
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol VCAN   Gene   UCSC   Ensembl
Aliases CSPG2, ERVR, GHAP, PG-M, WGN, WGN1
Gene name versican
Alternate names versican core protein, chondroitin sulfate proteoglycan core protein 2, glial hyaluronate-binding protein, large fibroblast proteoglycan, versican proteoglycan,
Gene location 5q14.2-q14.3 (83471673: 83582302)     Exons: 15     NC_000005.10
Gene summary(Entrez) This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
OMIM 118661

Protein Summary

Protein general information P13611  

Name: Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate binding protein) (GHAP) (Large fibroblast proteoglycan) (PG M)

Length: 3396  Mass: 372,820

Tissue specificity: Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is foun

Sequence MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNG
KDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGV
VFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKA
GVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS
DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKPKEATTIDLSILAETASPSLSKEPQMVS
DRTTPIIPLVDELPVIPTEFPPVGNIVSFEQKATVQPQAITDSLATKLPTPTGSTKKPWDMDDYSPSASGPLGKL
DISEIKEEVLQSTTGVSHYATDSWDGVVEDKQTQESVTQIEQIEVGPLVTSMEILKHIPSKEFPVTETPLVTARM
ILESKTEKKMVSTVSELVTTGHYGFTLGEEDDEDRTLTVGSDESTLIFDQIPEVITVSKTSEDTIHTHLEDLESV
SASTTVSPLIMPDNNGSSMDDWEERQTSGRITEEFLGKYLSTTPFPSQHRTEIELFPYSGDKILVEGISTVIYPS
LQTEMTHRRERTETLIPEMRTDTYTDEIQEEITKSPFMGKTEEEVFSGMKLSTSLSEPIHVTESSVEMTKSFDFP
TLITKLSAEPTEVRDMEEDFTATPGTTKYDENITTVLLAHGTLSVEAATVSKWSWDEDNTTSKPLESTEPSASSK
LPPALLTTVGMNGKDKDIPSFTEDGADEFTLIPDSTQKQLEEVTDEDIAAHGKFTIRFQPTTSTGIAEKSTLRDS
TTEEKVPPITSTEGQVYATMEGSALGEVEDVDLSKPVSTVPQFAHTSEVEGLAFVSYSSTQEPTTYVDSSHTIPL
SVIPKTDWGVLVPSVPSEDEVLGEPSQDILVIDQTRLEATISPETMRTTKITEGTTQEEFPWKEQTAEKPVPALS
STAWTPKEAVTPLDEQEGDGSAYTVSEDELLTGSERVPVLETTPVGKIDHSVSYPPGAVTEHKVKTDEVVTLTPR
IGPKVSLSPGPEQKYETEGSSTTGFTSSLSPFSTHITQLMEETTTEKTSLEDIDLGSGLFEKPKATELIEFSTIK
VTVPSDITTAFSSVDRLHTTSAFKPSSAITKKPPLIDREPGEETTSDMVIIGESTSHVPPTTLEDIVAKETETDI
DREYFTTSSPPATQPTRPPTVEDKEAFGPQALSTPQPPASTKFHPDINVYIIEVRENKTGRMSDLSVIGHPIDSE
SKEDEPCSEETDPVHDLMAEILPEFPDIIEIDLYHSEENEEEEEECANATDVTTTPSVQYINGKHLVTTVPKDPE
AAEARRGQFESVAPSQNFSDSSESDTHPFVIAKTELSTAVQPNESTETTESLEVTWKPETYPETSEHFSGGEPDV
FPTVPFHEEFESGTAKKGAESVTERDTEVGHQAHEHTEPVSLFPEESSGEIAIDQESQKIAFARATEVTFGEEVE
KSTSVTYTPTIVPSSASAYVSEEEAVTLIGNPWPDDLLSTKESWVEATPRQVVELSGSSSIPITEGSGEAEEDED
TMFTMVTDLSQRNTTDTLITLDTSRIITESFFEVPATTIYPVSEQPSAKVVPTKFVSETDTSEWISSTTVEEKKR
KEEEGTTGTASTFEVYSSTQRSDQLILPFELESPNVATSSDSGTRKSFMSLTTPTQSEREMTDSTPVFTETNTLE
NLGAQTTEHSSIHQPGVQEGLTTLPRSPASVFMEQGSGEAAADPETTTVSSFSLNVEYAIQAEKEVAGTLSPHVE
TTFSTEPTGLVLSTVMDRVVAENITQTSREIVISERLGEPNYGAEIRGFSTGFPLEEDFSGDFREYSTVSHPIAK
EETVMMEGSGDAAFRDTQTSPSTVPTSVHISHISDSEGPSSTMVSTSAFPWEEFTSSAEGSGEQLVTVSSSVVPV
LPSAVQKFSGTASSIIDEGLGEVGTVNEIDRRSTILPTAEVEGTKAPVEKEEVKVSGTVSTNFPQTIEPAKLWSR
QEVNPVRQEIESETTSEEQIQEEKSFESPQNSPATEQTIFDSQTFTETELKTTDYSVLTTKKTYSDDKEMKEEDT
SLVNMSTPDPDANGLESYTTLPEATEKSHFFLATALVTESIPAEHVVTDSPIKKEESTKHFPKGMRPTIQESDTE
LLFSGLGSGEEVLPTLPTESVNFTEVEQINNTLYPHTSQVESTSSDKIEDFNRMENVAKEVGPLVSQTDIFEGSG
SVTSTTLIEILSDTGAEGPTVAPLPFSTDIGHPQNQTVRWAEEIQTSRPQTITEQDSNKNSSTAEINETTTSSTD
FLARAYGFEMAKEFVTSAPKPSDLYYEPSGEGSGEVDIVDSFHTSATTQATRQESSTTFVSDGSLEKHPEVPSAK
AVTADGFPTVSVMLPLHSEQNKSSPDPTSTLSNTVSYERSTDGSFQDRFREFEDSTLKPNRKKPTENIIIDLDKE
DKDLILTITESTILEILPELTSDKNTIIDIDHTKPVYEDILGMQTDIDTEVPSEPHDSNDESNDDSTQVQEIYEA
AVNLSLTEETFEGSADVLASYTQATHDESMTYEDRSQLDHMGFHFTTGIPAPSTETELDVLLPTATSLPIPRKSA
TVIPEIEGIKAEAKALDDMFESSTLSDGQAIADQSEIIPTLGQFERTQEEYEDKKHAGPSFQPEFSSGAEEALVD
HTPYLSIATTHLMDQSVTEVPDVMEGSNPPYYTDTTLAVSTFAKLSSQTPSSPLTIYSGSEASGHTEIPQPSALP
GIDVGSSVMSPQDSFKEIHVNIEATFKPSSEEYLHITEPPSLSPDTKLEPSEDDGKPELLEEMEASPTELIAVEG
TEILQDFQNKTDGQVSGEAIKMFPTIKTPEAGTVITTADEIELEGATQWPHSTSASATYGVEAGVVPWLSPQTSE
RPTLSSSPEINPETQAALIRGQDSTIAASEQQVAARILDSNDQATVNPVEFNTEVATPPFSLLETSNETDFLIGI
NEESVEGTAIYLPGPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR
CLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQW
IGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYHLTYTCKKGTVACGQPP
VVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAIPKITCMNPSAYQRTYSMKYFKNSSSAKD
NSINTSKHDHRWSRRWQESRR
Structural information
Protein Domains
Ig-like (21-146)
Link (150-245)
Link (251-347)
EGF-like (3089-3125)
EGF-like (3127-3163)
Interpro:  IPR001304 IPR016186 IPR018378 IPR033987 IPR016187 IPR001881 IPR013032 IPR000742 IPR000152 IPR018097 IPR007110 IPR013783 IPR003599 IPR013106 IPR000538 IPR000436
Prosite:   PS00010 PS00615 PS50041 PS00022 PS01186 PS50026 PS01187 PS50835 PS01241 PS50963 PS50923

Pfam:  
PF00008 PF00059 PF00084 PF07686 PF00193
CDD:   cd00033 cd03588
MINT:   4529155
STRING:   ENSP00000265077;
Other Databases GeneCards:  VCAN;  Malacards:  VCAN

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001501 skeletal system developme
nt
IBA biological_process
GO:0001649 osteoblast differentiatio
n
IDA biological_process
GO:0005201 extracellular matrix stru
ctural constituent
IBA molecular_function
GO:0005509 calcium ion binding
IEA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005539 glycosaminoglycan binding
TAS molecular_function
GO:0005540 hyaluronic acid binding
IEA molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
IEA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0007155 cell adhesion
IEA biological_process
GO:0007275 multicellular organism de
velopment
TAS biological_process
GO:0007417 central nervous system de
velopment
IBA biological_process
GO:0008037 cell recognition
TAS biological_process
GO:0008347 glial cell migration
IDA biological_process
GO:0008347 glial cell migration
IDA biological_process
GO:0016020 membrane
IDA cellular_component
GO:0030198 extracellular matrix orga
nization
TAS biological_process
GO:0030203 glycosaminoglycan metabol
ic process
TAS biological_process
GO:0030206 chondroitin sulfate biosy
nthetic process
TAS biological_process
GO:0030207 chondroitin sulfate catab
olic process
TAS biological_process
GO:0030208 dermatan sulfate biosynth
etic process
TAS biological_process
GO:0030246 carbohydrate binding
IEA molecular_function
GO:0031012 extracellular matrix
IDA cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043231 intracellular membrane-bo
unded organelle
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
ISS cellular_component
GO:0001501 skeletal system developme
nt
IBA biological_process
GO:0001649 osteoblast differentiatio
n
IDA biological_process
GO:0005201 extracellular matrix stru
ctural constituent
IBA molecular_function
GO:0005509 calcium ion binding
IEA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005539 glycosaminoglycan binding
TAS molecular_function
GO:0005540 hyaluronic acid binding
IEA molecular_function
GO:0005540 hyaluronic acid binding
IEA molecular_function
GO:0005540 hyaluronic acid binding
TAS molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
TAS cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0007155 cell adhesion
IEA biological_process
GO:0007155 cell adhesion
TAS biological_process
GO:0007275 multicellular organism de
velopment
TAS biological_process
GO:0007417 central nervous system de
velopment
IBA biological_process
GO:0008037 cell recognition
TAS biological_process
GO:0008347 glial cell migration
IDA biological_process
GO:0008347 glial cell migration
IDA biological_process
GO:0016020 membrane
IDA cellular_component
GO:0030198 extracellular matrix orga
nization
TAS biological_process
GO:0030203 glycosaminoglycan metabol
ic process
TAS biological_process
GO:0030206 chondroitin sulfate biosy
nthetic process
TAS biological_process
GO:0030207 chondroitin sulfate catab
olic process
TAS biological_process
GO:0030208 dermatan sulfate biosynth
etic process
TAS biological_process
GO:0030246 carbohydrate binding
IEA molecular_function
GO:0031012 extracellular matrix
IDA cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043231 intracellular membrane-bo
unded organelle
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
ISS cellular_component
GO:0001501 skeletal system developme
nt
IBA biological_process
GO:0001649 osteoblast differentiatio
n
IDA biological_process
GO:0005201 extracellular matrix stru
ctural constituent
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005539 glycosaminoglycan binding
TAS molecular_function
GO:0005540 hyaluronic acid binding
TAS molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
TAS cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0005796 Golgi lumen
TAS cellular_component
GO:0007155 cell adhesion
TAS biological_process
GO:0007275 multicellular organism de
velopment
TAS biological_process
GO:0007417 central nervous system de
velopment
IBA biological_process
GO:0008037 cell recognition
TAS biological_process
GO:0008347 glial cell migration
IDA biological_process
GO:0008347 glial cell migration
IDA biological_process
GO:0016020 membrane
IDA cellular_component
GO:0030198 extracellular matrix orga
nization
TAS biological_process
GO:0030203 glycosaminoglycan metabol
ic process
TAS biological_process
GO:0030206 chondroitin sulfate biosy
nthetic process
TAS biological_process
GO:0030207 chondroitin sulfate catab
olic process
TAS biological_process
GO:0030208 dermatan sulfate biosynth
etic process
TAS biological_process
GO:0031012 extracellular matrix
IDA cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043202 lysosomal lumen
TAS cellular_component
GO:0043231 intracellular membrane-bo
unded organelle
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
ISS cellular_component

KEGG pathways

hsa04514  Cell adhesion molecules

Diseases

Associated diseases References
Endometriosis (Peritoneal) PMID: 27533311
Brain hemorrhage PMID: 16917090
Depression PMID: 20516156
Diminished ovarian reserve (DOR) PMID: 22906700, 22246450
Female infertility PMID: 23554803
Female infertility PMID: 24041818
Peritoneal endometriosis INFBASE27533311
Ovarian hyperstimulation syndrome(OHSS) PMID: 16128122
Peritoneal endometriosis PMID: 27533311
Polycystic ovary syndrome (PCOS) PMID: 27908842
Unexplained infertility PMID: 19939360
Vitreoretinal degeneration KEGG: H00805
Wagner syndrome OMIM: 118661

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
27533311 Endometrio
sis (Perit
oneal)

23 Endometrioti
c peritoneum, 2
5 non endometri
otic peritoneum

Show abstract