Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 1588
Gene Summary     SNPs    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol CYP19A1   Gene   UCSC   Ensembl
Aliases ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
Gene name cytochrome P450 family 19 subfamily A member 1
Alternate names aromatase, cytochrome P-450AROM, cytochrome P450 19A1, cytochrome P450, family 19, subfamily A, polypeptide 1, cytochrome P450, subfamily XIX (aromatization of androgens), estrogen synthase, estrogen synthetase, flavoprotein-linked monooxygenase, microsomal monoo,
Gene location 15q21.2 (51338597: 51208056)     Exons: 12     NC_000015.10
Gene summary(Entrez) This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
OMIM 107910

SNPs

rs1062033

Strand:    Allele origin:   Allele change: C/G   Mutation type: snp

CM000677.2   g.51255741C>G
NC_000015.10   g.51255741C>G
NC_000015.9   g.51547938C>G
NG_007982.1   g.87858G>C
NM_000103.3   c.-38-12791G>C
NM_001347248.1   c.-38-12791G>C
NM_001347249.1   c.-38-12791G>C
NM_001347250.1   c.-38-12791G>C
NM_001347251.1   c.-38-12791G>C
NM_001347252.1   c.-38-12791G>C
NM_001347253.1   c.-262G>C
NM_031226.2   c.-38-12791G>C
NR_146310.1   n.195-22242C>G
rs10046

Strand: -   Allele origin: unknown  Allele change: C/T   Mutation type: snp

  
NG_007982.1   g.132810C>T
NC_000015.9   g.51502986G>A
NC_000015.10   g.51210789G>A
NM_000103.3   c.*19C>T
NM_001347249.1   c.*19C>T
NM_001347248.1   c.*19C>T
NM_001347252.1   c.*19C>T
NM_001347251.1   c.*19C>T
NM_001347250.1   c.*19C>T
NM_001347256.1   c.*19C>T
NM_001347255  
Clinical Significance: Benign

rs1143704

Strand:    Allele origin:   Allele change: A/T   Mutation type: snp

CM000677.2   g.51218505T>A
NC_000015.10   g.51218505T>A
NC_000015.9   g.51510702T>A
NG_007982.1   g.125094A>T
NM_000103.3   c.743+36A>T
NM_001347248.1   c.743+36A>T
NM_001347249.1   c.743+36A>T
NM_001347250.1   c.743+36A>T
NM_001347251.1   c.743+36A>T
NM_001347252.1   c.743+36A>T
NM_001347253.1   c.743+36A>T
NM_001347254.1   c.743+36A>T
NM_001347255.1   c.743+36A>T
NM_001347256.1   c.743+36A>T
NM_031226.2   c.743+36A>T
NR_146310.1   n.195-59478T>A
rs16964258

Strand:    Allele origin:   Allele change: A/G   Mutation type: snp

CM000677.2   g.51313211A>G
NC_000015.10   g.51313211A>G
NC_000015.9   g.51605408A>G
NG_007982.1   g.30388T>C
NM_000103.3   c.-39+25284T>C
NM_001347248.1   c.-39+10605T>C
NM_001347249.1   c.-39+5222T>C
NM_031226.2   c.-39+10605T>C
NR_107012.1   n.-823A>G
rs1803154

Strand:    Allele origin:   Allele change: A/T   Mutation type: snp

CM000677.2   g.51227908T>A
NC_000015.10   g.51227908T>A
NC_000015.9   g.51520105T>A
NG_007982.1   g.115691A>T
NM_000103.3   c.322A>T
NM_001347248.1   c.322A>T
NM_001347249.1   c.322A>T
NM_001347250.1   c.322A>T
NM_001347251.1   c.322A>T
NM_001347252.1   c.322A>T
NM_001347253.1   c.322A>T
NM_001347254.1   c.322A>T
NM_001347255.1   c.322A>T
NM_001347256.1   c.322A>T
NM_031226.2   c.322A>T
NP_000094.2   p.Lys108Ter
NP_001334177.1   p.Lys108Ter
NP_001334178.1   p.Lys108Ter
NP_001334179.1   p.Lys108Ter
NP_001334180.1   p.Lys108Ter
NP_001334181.1   p.Lys108Ter
NP_001334182.1   p.Lys108Ter
NP_001334183.1   p.Lys108Ter
NP_001334184.1   p.Lys108Ter
NP_001334185.1   p.Lys108Ter
NP_112503.1   p.Lys108Ter
NR_146310.1   n.195-50075T>A
XP_005254247.1   p.Lys108Ter
XP_005254248.1   p.Lys108Ter
XP_005254249.1   p.Lys108Ter
rs1870049

Strand:    Allele origin:   Allele change: C/G/T   Mutation type: snp

CM000677.2   g.51333026T>C
CM000677.2   g.51333026T>G
NC_000015.10   g.51333026T>C
NC_000015.10   g.51333026T>G
NC_000015.9   g.51625223T>C
NC_000015.9   g.51625223T>G
NG_007982.1   g.10573A>C
NG_007982.1   g.10573A>G
NM_000103.3   c.-39+5469A>C
NM_000103.3   c.-39+5469A>G
NM_031226.2   c.-148+5469A>C
NM_031226.2   c.-148+5469A>G
rs2304462

Strand:    Allele origin:   Allele change: A/C/T   Mutation type: snp

CM000677.2   g.51215770C>A
CM000677.2   g.51215770C>T
NC_000015.10   g.51215770C>A
NC_000015.10   g.51215770C>T
NC_000015.9   g.51507967C>T
NG_007982.1   g.127829G>A
NG_007982.1   g.127829G>T
NM_000103.3   c.791G>A
NM_000103.3   c.791G>T
NM_001347248.1   c.791G>A
NM_001347248.1   c.791G>T
NM_001347249.1   c.791G>A
NM_001347249.1   c.791G>T
NM_001347250.1   c.791G>A
NM_001347250.1   c.791G>T
NM_001347251.1   c.791G>A
NM_001347251.1   c.791G>T
NM_001347252.1   c.791G>A
NM_001347252.1   c.791G>T
NM_001347253.1   c.791G>A
NM_001347253.1   c.791G>T
NM_001347254.1   c.791G>A
NM_001347254.1   c.791G>T
NM_001347255.1   c.791G>A
NM_001347255.1   c.791G>T
NM_001347256.1   c.791G>A
NM_001347256.1   c.791G>T
NM_031226.2   c.791G>A
NM_031226.2   c.791G>T
NP_000094.2   p.Arg264His
NP_000094.2   p.Arg264Leu
NP_001334177.1   p.Arg264His
NP_001334177.1   p.Arg264Leu
NP_001334178.1   p.Arg264His
NP_001334178.1   p.Arg264Leu
NP_001334179.1   p.Arg264His
NP_001334179.1   p.Arg264Leu
NP_001334180.1   p.Arg264His
NP_001334180.1   p.Arg264Leu
NP_001334181.1   p.Arg264His
NP_001334181.1   p.Arg264Leu
NP_001334182.1   p.Arg264His
NP_001334182.1   p.Arg264Leu
NP_001334183.1   p.Arg264His
NP_001334183.1   p.Arg264Leu
NP_001334184.1   p.Arg264His
NP_001334184.1   p.Arg264Leu
NP_001334185.1   p.Arg264His
NP_001334185.1   p.Arg264Leu
NP_112503.1   p.Arg264His
NP_112503.1   p.Arg264Leu
NR_146310.1   n.195-62213C>A
NR_146310.1   n.195-62213C>T
XP_005254247.1   p.Arg264His
XP_005254248.1   p.Arg264His
XP_005254248.1   p.Arg264Leu
XP_005254249.1   p.Arg205His
rs2236722

Strand: -   Allele origin: unknown  Allele change: C/T   Mutation type: snp

NC_000015.10   g.51242798A>G
NC_000015.9   g.51534995A>G
NG_007982.1   g.100801T>C
NM_000103.3   c.115T>C
NM_001347248.1   c.115T>C
NM_001347253.1   c.115T>C
NM_001347254.1   c.115T>C
NM_001347255.1   c.115T>C
NM_001347256.1   c.115T>C
NM_001347249.1   c.115T>C
NM_001347250.  
Clinical Significance: Likely benign

rs2899470

Strand:    Allele origin:   Allele change: G/T   Mutation type: snp

CM000677.2   g.51211480T>G
NC_000015.10   g.51211480T>G
NC_000015.9   g.51503677T>G
NG_007982.1   g.132119A>C
NM_000103.3   c.1264-424A>C
NM_001347248.1   c.1264-424A>C
NM_001347249.1   c.1264-424A>C
NM_001347250.1   c.1264-424A>C
NM_001347251.1   c.1264-424A>C
NM_001347252.1   c.1264-424A>C
NM_001347253.1   c.1264-424A>C
NM_001347254.1   c.1264-424A>C
NM_001347255.1   c.1264-424A>C
NM_001347256.1   c.1264-424A>C
NM_031226.2   c.1264-424A>C
NR_146310.1   n.195-66503T>G
rs700519

Strand:    Allele origin: T(germline)/C(germline)  Allele change: C/T   Mutation type: snp

CM000677.2   g.51215771G>A
NC_000015.10   g.51215771G>A
NC_000015.9   g.51507968G>A
NG_007982.1   g.127828C>T
NM_000103.3   c.790C>T
NM_001347248.1   c.790C>T
NM_001347249.1   c.790C>T
NM_001347250.1   c.790C>T
NM_001347251.1   c.790C>T
NM_001347252.1   c.790C>T
NM_001347253.1   c.790C>T
NM_001347254.1   c.790C>T
NM_001347255.1   c.790C>T
NM_001347256.1   c.790C>T
NM_031226.2   c.790C>T
NP_000094.2   p.Arg264Cys
NP_001334177.1   p.Arg264Cys
NP_001334178.1   p.Arg264Cys
NP_001334179.1   p.Arg264Cys
NP_001334180.1   p.Arg264Cys
NP_001334181.1   p.Arg264Cys
NP_001334182.1   p.Arg264Cys
NP_001334183.1   p.Arg264Cys
NP_001334184.1   p.Arg264Cys
NP_001334185.1   p.Arg264Cys
NP_112503.1   p.Arg264Cys
NR_146310.1   n.195-62212G>A
XP_005254247.1   p.Arg264Cys
XP_005254248.1   p.Arg264Cys
XP_005254249.1   p.Arg205Cys
Clinical Significance: Likely benign

rs936307

Strand:    Allele origin:   Allele change: A/C   Mutation type: snp

CM000677.2   g.51287778C>A
NC_000015.10   g.51287778C>A
NC_000015.9   g.51579975C>A
NG_007982.1   g.55821G>T
NM_000103.3   c.-38-44828G>T
NM_001347248.1   c.-39+36038G>T
NM_001347249.1   c.-39+30655G>T
NM_001347250.1   c.-39+472G>T
NM_031226.2   c.-39+36038G>T
NR_146310.1   n.263-5836C>A

Protein Summary

Protein general information P11511  

Name: Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P 450AROM) (Cytochrome P450 19A1) (Estrogen synthase)

Length: 503  Mass: 57,883

Tissue specificity: Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads. {ECO

Sequence MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACN
YYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMK
ALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQ
ALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR
KALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAI
LVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
Structural information
Interpro:  IPR001128 IPR017972 IPR002401
Prosite:   PS00086

Pfam:  
PF00067

PDB:  
1TQA 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8
PDBsum:   1TQA 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8
MINT:   4054553
STRING:   ENSP00000260433;
Other Databases GeneCards:  CYP19A1;  Malacards:  CYP19A1

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0002677 negative regulation of ch
ronic inflammatory respon
se
IEA biological_process
GO:0005506 iron ion binding
IEA molecular_function
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006694 steroid biosynthetic proc
ess
TAS biological_process
GO:0006703 estrogen biosynthetic pro
cess
TAS biological_process
GO:0008209 androgen metabolic proces
s
IEA biological_process
GO:0008395 steroid hydroxylase activ
ity
TAS molecular_function
GO:0008395 steroid hydroxylase activ
ity
TAS molecular_function
GO:0009055 electron carrier activity
TAS molecular_function
GO:0010760 negative regulation of ma
crophage chemotaxis
IEA biological_process
GO:0016020 membrane
TAS cellular_component
GO:0016125 sterol metabolic process
TAS biological_process
GO:0016712 oxidoreductase activity,
acting on paired donors,
with incorporation or red
uction of molecular oxyge
n, reduced flavin or flav
oprotein as one donor, an
d incorporation of one at
om of oxygen
TAS molecular_function
GO:0019825 oxygen binding
TAS molecular_function
GO:0020037 heme binding
IDA molecular_function
GO:0055114 oxidation-reduction proce
ss
IEA biological_process
GO:0060736 prostate gland growth
IEA biological_process
GO:0070330 aromatase activity
IDA molecular_function
GO:0002677 negative regulation of ch
ronic inflammatory respon
se
IEA biological_process
GO:0004497 monooxygenase activity
IEA molecular_function
GO:0005506 iron ion binding
IEA molecular_function
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006694 steroid biosynthetic proc
ess
TAS biological_process
GO:0006703 estrogen biosynthetic pro
cess
TAS biological_process
GO:0008209 androgen metabolic proces
s
IEA biological_process
GO:0008395 steroid hydroxylase activ
ity
TAS molecular_function
GO:0008395 steroid hydroxylase activ
ity
TAS molecular_function
GO:0009055 electron carrier activity
TAS molecular_function
GO:0010760 negative regulation of ma
crophage chemotaxis
IEA biological_process
GO:0016020 membrane
IEA cellular_component
GO:0016020 membrane
IEA cellular_component
GO:0016020 membrane
TAS cellular_component
GO:0016125 sterol metabolic process
TAS biological_process
GO:0016491 oxidoreductase activity
IEA molecular_function
GO:0016705 oxidoreductase activity,
acting on paired donors,
with incorporation or red
uction of molecular oxyge
n
IEA molecular_function
GO:0016712 oxidoreductase activity,
acting on paired donors,
with incorporation or red
uction of molecular oxyge
n, reduced flavin or flav
oprotein as one donor, an
d incorporation of one at
om of oxygen
IEA molecular_function
GO:0016712 oxidoreductase activity,
acting on paired donors,
with incorporation or red
uction of molecular oxyge
n, reduced flavin or flav
oprotein as one donor, an
d incorporation of one at
om of oxygen
TAS molecular_function
GO:0019825 oxygen binding
TAS molecular_function
GO:0020037 heme binding
IEA molecular_function
GO:0020037 heme binding
IDA molecular_function
GO:0046872 metal ion binding
IEA molecular_function
GO:0055114 oxidation-reduction proce
ss
IEA biological_process
GO:0055114 oxidation-reduction proce
ss
IEA biological_process
GO:0060736 prostate gland growth
IEA biological_process
GO:0070330 aromatase activity
IDA molecular_function
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006694 steroid biosynthetic proc
ess
TAS biological_process
GO:0006703 estrogen biosynthetic pro
cess
TAS biological_process
GO:0008395 steroid hydroxylase activ
ity
TAS molecular_function
GO:0008395 steroid hydroxylase activ
ity
TAS molecular_function
GO:0009055 electron carrier activity
TAS molecular_function
GO:0016020 membrane
TAS cellular_component
GO:0016125 sterol metabolic process
TAS biological_process
GO:0016712 oxidoreductase activity,
acting on paired donors,
with incorporation or red
uction of molecular oxyge
n, reduced flavin or flav
oprotein as one donor, an
d incorporation of one at
om of oxygen
TAS molecular_function
GO:0019825 oxygen binding
TAS molecular_function
GO:0020037 heme binding
IDA molecular_function
GO:0070330 aromatase activity
IDA molecular_function

KEGG pathways

hsa01100  Metabolic pathways
hsa00140  Steroid hormone biosynthesis
hsa04913  Ovarian steroidogenesis

Diseases

Associated diseases References
Alzheimer's disease PMID: 16020944
Ambiguous genitalia PMID: 14602738
Aromatase deficiency OMIM: 107910
Aromatase excess syndrome OMIM: 107910
Arthritis PMID: 12154211
Asthenozoospermia PMID: 23252370
Atherosclerosis PMID: 16045239
Attention-deficit hyperactivity disorder (ADHD) PMID: 11140838
Autism PMID: 19598235
Azoospermia PMID: 16213843
Bone density PMID: 15613678
Cancer PMID: 14508827
Chronic obstructive pulmonary disease (COPD) PMID: 19625176
Connective tissue diseases PMID: 19527514
Diabetes PMID: 16949391
Endometrial cancer PMID: 22320986
Endometrial polyp PMID: 25354862
Female infertility PMID: 19549443
Female pseudohermaphroditism PMID: 9829218
Gynecomastia PMID: 18426832
Hyperandrogenism PMID: 15802318
Hyperandrogenism PMID: 22798247
Hypergonadotropic hypogonadism PMID: 9177373
Male infertility PMID: 16873132
Migraine disorders PMID: 19093296
Obesity PMID: 19491387
Oligozoospermia PMID: 23001776
Osteoporosis PMID: 14715870
Ovarian hyperstimulation syndrome (OHSS) PMID: 18159088
Parkinson's disease PMID: 18568448
Pelvic endometriosis PMID: 15309998
Polycystic ovary syndrome (PCOS) PMID: 21262361
Premature ovarian failure ( POF) PMID: 21269619
Recurrent miscarriage PMID: 19152063
Rheumatoid arthritis PMID: 19555469
Endometriosis INFBASE28002584
Female infertility INFBASE27167072
Endometriosis associated infertility INFBASE24968701
Poor ovarian response INFBASE21474127
Female infertility INFBASE15640252
Sertoli cell-only syndrome (SCOS) PMID: 19906189
Spermatogenetic defects PMID: 18980759
Teratozoospermia PMID: 23252370

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
11502834 Endometrio
sis


SCARB1
CYP19A1
Show abstract
18711959 Endometrio
sis

23 (12 endometr
iotic, 11 witho
ut endometriosi
s)
Aromatase
Show abstract
18165439 Endometrio
sis


USF2
SF-1
StAR
aromatase
Show abstract
17454161 Endometrio
sis

25 (16 samples
of ovarian endo
metriosis, 9 of
normal endomet
rium)
Aromatase
17beta-HSD types 1
17beta-HSD types 7
sulfatase
Erbeta
Eralpha
Show abstract
17336977 Endometrio
sis

74 (62 women wi
th endometriosi
s, 12 without e
ndometriosis)
aromatase
Show abstract
18089598 Endometrio
sis

68 (35 patients
with peritonea
l or ovarian en
dometriosis, 33
women without
endometriosis)
Aromatase
Show abstract
15840311 Endometrio
sis

40 (25 eutopic
endometrium, 23
cases of ovari
an endometriosi
s, 11 cases of
vagina-rectum e
ndometriosis, 8
cases of perit
oneum endometri
osis, 16 cases
of uterine sero
sa endometriosi
s )
P450
estrogen receptor (ER)
Show abstract
15640252 Endometrio
sis
Ser312Gly polymorphism in HSD17B1, Arg264Cys polymorphism in CYP19 Japanes
e
138 (59 had no
endometriosis,
21 had stage I,
10 had stage I
I, 23 had stage
III, 25 had st
age IV)
HSD17B1
CYP19
Show abstract
26530052 Endometrio
sis

44 (16 patients
with endometri
osis, 28 contro
ls)
Female infertility CYP19
PII
LRH-1 and SF-1
Show abstract
12620480 Endometrio
sis
CYP19 VNTR (TTTA)(10) allele, CYP1A1 m1 polymorphism, GSTM1 null deletion, GSTT1 null deletion
621 (275 women
with sporadic e
ndometriosis, 3
46 fertile endo
metriosis-free
women)
Female infertility CYP1A1
CYP19
GSTM1
and GSTT1
Show abstract
24411031 Endometrio
sis
CYP19 (rs8042086) Taiwane
se Han
292 (121 patien
ts with advance
d stage endomet
riosis, 171 con
trol women)
Female infertility HSD17B1
HSD17B2
HSD17B5
HSD17B6
CYP17
CYP19
ER?
ER?
and PGR
Show abstract
21154336 Endometrio
sis
240G/G polymorphism, 115T/C and 1531C/T polymorphisms Chinese
202 (102 patien
ts with endomet
riosis of III-I
V stage, 100 in
dividuals witho
ut endometriosi
s)
CYP19
Show abstract
18930188 Endometrio
sis
CYP17 (T>C), CYP19 (C1558T, Val80)
196 (104 patien
ts with endomet
riosis, 86 cont
rols)
CYP19
Show abstract
11925378 Endometrio
sis
3 bp I/D polymorphism of the CYP19 Japanes
e
384 (140 patien
ts with endomet
riosis, 67 with
adenomyosis an
d/or leiomyomas
and 177 health
y control women
)
CYP19
CYP17
Show abstract
23139742 Endometrio
sis
FSHR (rs6165 (genotype GG+GA, 307(Ala/Ala)+307(Ala/Thr)) of FSHR, rs 6166 (genotype GG+GA, 680(Ser/Asn)+680(Ser/Ser))), HSD17B3 (rs2066479 (genotype AA+AG, 289(Ser/Ser)+289(Ser/Gly))), CYP19 (rs700519 (genotype TT+TC, 264(Cys/Cys)+264(Cys/Arg))) Taiwane
se Chin
ese
637 (300 patien
ts with endrome
triosis)
FSHR
HSD17B3
CYP19
Show abstract
20553220 Endometrio
sis


CYP19
Show abstract
24968701 Endometrio
sis
rs2236722:T>C, rs700518:A>G, rs10046:T>C and [TTTA]n polymorphisms Chinese
530 (225 health
y control femal
es, 146 patient
s with endometr
iosis, 94 endom
etriosis women
with chocolate
cyst and 65 wom
en with inferti
lity resulting
from endometrio
sis)
Female infertility
Show abstract
25773531 Endometrio
sis

81 (40 infertil
e patients who
received the i
ndication of as
sisted reproduc
tion technique
s solely becaus
e of the presen
ce of endometri
osis, 41 patien
ts whose proced
ure was indica
ted exclusively
owing to the p
resence of male
-factor infert
ility, tubal-fa
ctor infertilit
y, or both)
Female infertility
Show abstract
21958689 Endometrio
sis

823 (256 endome
triosis, 567 fe
male control su
bjects without
a history of en
dometriosis)
CYP19A1
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27167072 Endometrio
sis

24 infertile pa
tients with and
without endome
triosis
Female infertility
Show abstract
21474127 Endometrio
sis

117 (35 control
s (no ovarian f
actor, NOF), 28
poor responder
s (PR), 32 pati
ents with endom
etriosis (EM),
and 22 patients
with polycysti
c ovary syndrom
e (PCOS))
Female infertility FSHR
PAPP
and Cyp19A1
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8550748 Endometrio
sis

21 (14 patients
with histologi
cally documente
d pelvic endome
triosis, 7 norm
al endometrial
tissues)
IL-6
IL-11
P450arom
Show abstract
15743158 Endometrio
sis

43 (23 women wi
th endometriosi
s, 20 fertile c
yclic women und
ergoing tubal s
terilization)
P450Arom
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28002584 Endometrio
sis
CYP19A1 (rs2899470), GSTM1, GSTT1, GSTP1( rs1695) Chinese
537 (262 endome
triosis patient
s, 275 control)
GSTM1
GSTT1
GSTP1
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