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Gene id

1956

Gene Summary SNPs Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

EGFR Gene UCSC Ensembl

Aliases

ERBB, ERBB1, HER1, NISBD2, PIG61, mENA

Gene name

epidermal growth factor receptor

Alternate names

epidermal growth factor receptor, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, erb-b2 receptor tyrosine kinase 1, proto-oncogene c-ErbB-1, receptor tyrosine-protein ki,

Gene location

7p11.2 (55019031: 55207337) Exons: 30 NC_000007.14

Gene summary(Entrez)

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]

OMIM

131550

SNPs

rs2227983

Strand:    Allele origin: G(germline)/A(germline)  Allele change: A/C/G/T   Mutation type: snp

CM000669.2   g.55161562G>A
NC_000007.13   g.55229255G>A
NC_000007.14   g.55161562G>A
NG_007726.3   g.147531G>A
NM_001346897.1   c.1427G>A
NM_001346898.1   c.1562G>A
NM_001346899.1   c.1427G>A
NM_001346900.1   c.1403G>A
NM_001346941.1   c.761G>A
NM_005228.3   c.1562G>A
NM_005228.4   c.1562G>A
NM_201282.1   c.1562G>A
NM_201284.1   c.1562G>A
NP_001333826.1   p.Arg476Lys
NP_001333827.1   p.Arg521Lys
NP_001333828.1   p.Arg476Lys
NP_001333829.1   p.Arg468Lys
NP_001333870.1   p.Arg254Lys
NP_005219.2   p.Arg521Lys
NP_958439.1   p.Arg521Lys
NP_958441.1   p.Arg521Lys
XP_005271803.1   p.Arg476Lys
XP_005271804.1   p.Arg468Lys
XP_005271805.1   p.Arg521Lys
Clinical Significance: Likely benign

Protein Summary

Protein general information

P00533

Name: Epidermal growth factor receptor (EC 2.7.10.1) (Proto oncogene c ErbB 1) (Receptor tyrosine protein kinase erbB 1)

Length: 1210 Mass: 134,277

Tissue specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. {ECO

Sequence

MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYD
LSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRF
SNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG
KSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVA
FRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGL
RSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVS
CRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVR
KRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA
TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM
NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP
QRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACI
DRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHY
QDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA

Structural information

Protein Domains	Protein (712-979)
Interpro:	IPR006211 IPR006212 IPR032778 IPR009030 IPR011009 IPR032675 IPR000719 IPR017441 IPR000494 IPR001245 IPR008266 IPR020635 IPR016245
Prosite:	PS00107 PS50011 PS00109
Pfam:	PF00757 PF14843 PF07714 PF01030
PDB:	1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2EXP 2EXQ 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M0B 2M20 2N5S 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3G5V 3G5Y 3GOP 3GT8
PDBsum:	1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2EXP 2EXQ 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M0B 2M20 2N5S 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3G5V 3G5Y 3GOP 3GT8
DIP:	405
MINT:	206389
STRING:	ENSP00000275493;

Other Databases

GeneCards: EGFR; Malacards: EGFR

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000139	Golgi membrane	IEA	cellular_component
GO:0000165	MAPK cascade	TAS	biological_process
GO:0000186	activation of MAPKK activ ity	IEA	biological_process
GO:0000902	cell morphogenesis	IEA	biological_process
GO:0001503	ossification	NAS	biological_process
GO:0001892	embryonic placenta develo pment	IEA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001942	hair follicle development	IEA	biological_process
GO:0003682	chromatin binding	IDA	molecular_function
GO:0003690	double-stranded DNA bindi ng	NAS	molecular_function
GO:0004709	MAP kinase kinase kinase activity	NAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IMP	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IDA	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	EXP	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IDA	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004714	transmembrane receptor pr otein tyrosine kinase act ivity	TAS	molecular_function
GO:0004716	signal transducer, downst ream of receptor, with pr otein tyrosine kinase act ivity	IEA	molecular_function
GO:0004888	transmembrane signaling r eceptor activity	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	NAS	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	NAS	molecular_function
GO:0005088	Ras guanyl-nucleotide exc hange factor activity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005615	extracellular space	NAS	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005768	endosome	IDA	cellular_component
GO:0005768	endosome	IDA	cellular_component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005925	focal adhesion	IDA	cellular_component
GO:0006950	response to stress	NAS	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	IDA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	IDA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	IDA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological_process
GO:0007202	activation of phospholipa se C activity	TAS	biological_process
GO:0007435	salivary gland morphogene sis	IEA	biological_process
GO:0007611	learning or memory	ISS	biological_process
GO:0008283	cell proliferation	IDA	biological_process
GO:0008284	positive regulation of ce ll proliferation	IDA	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0010008	endosome membrane	IDA	cellular_component
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016323	basolateral plasma membra ne	IDA	cellular_component
GO:0016337	single organismal cell-ce ll adhesion	IMP	biological_process
GO:0018108	peptidyl-tyrosine phospho rylation	IEA	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0019903	protein phosphatase bindi ng	IPI	molecular_function
GO:0021795	cerebral cortex cell migr ation	IEA	biological_process
GO:0030307	positive regulation of ce ll growth	IDA	biological_process
GO:0030335	positive regulation of ce ll migration	IMP	biological_process
GO:0031625	ubiquitin protein ligase binding	IPI	molecular_function
GO:0031659	positive regulation of cy clin-dependent protein se rine/threonine kinase act ivity involved in G1/S tr ansition of mitotic cell cycle	IDA	biological_process
GO:0031901	early endosome membrane	IDA	cellular_component
GO:0031965	nuclear membrane	IEA	cellular_component
GO:0035413	positive regulation of ca tenin import into nucleus	IMP	biological_process
GO:0038128	ERBB2 signaling pathway	TAS	biological_process
GO:0042059	negative regulation of ep idermal growth factor rec eptor signaling pathway	TAS	biological_process
GO:0042177	negative regulation of pr otein catabolic process	IDA	biological_process
GO:0042327	positive regulation of ph osphorylation	IDA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0043006	activation of phospholipa se A2 activity by calcium -mediated signaling	TAS	biological_process
GO:0043066	negative regulation of ap optotic process	IMP	biological_process
GO:0043235	receptor complex	IDA	cellular_component
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043547	positive regulation of GT Pase activity	IEA	biological_process
GO:0045121	membrane raft	IDA	cellular_component
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045739	positive regulation of DN A repair	IDA	biological_process
GO:0045740	positive regulation of DN A replication	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0046777	protein autophosphorylati on	IMP	biological_process
GO:0046854	phosphatidylinositol phos phorylation	IEA	biological_process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IEA	biological_process
GO:0048471	perinuclear region of cyt oplasm	IEA	cellular_component
GO:0048546	digestive tract morphogen esis	IEA	biological_process
GO:0050679	positive regulation of ep ithelial cell proliferati on	IDA	biological_process
GO:0050730	regulation of peptidyl-ty rosine phosphorylation	IMP	biological_process
GO:0050999	regulation of nitric-oxid e synthase activity	IDA	biological_process
GO:0051015	actin filament binding	IDA	molecular_function
GO:0051205	protein insertion into me mbrane	TAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0060571	morphogenesis of an epith elial fold	IEA	biological_process
GO:0061029	eyelid development in cam era-type eye	IEA	biological_process
GO:0070141	response to UV-A	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0070435	Shc-EGFR complex	ISS	cellular_component
GO:0071230	cellular response to amin o acid stimulus	IEA	biological_process
GO:0071364	cellular response to epid ermal growth factor stimu lus	ISS	biological_process
GO:0071392	cellular response to estr adiol stimulus	IDA	biological_process
GO:0097489	multivesicular body, inte rnal vesicle lumen	IDA	cellular_component
GO:1903800	positive regulation of pr oduction of miRNAs involv ed in gene silencing by m iRNA	IMP	biological_process
GO:2000145	regulation of cell motili ty	TAS	biological_process
GO:0030122	AP-2 adaptor complex	TAS	cellular_component
GO:0030235	nitric-oxide synthase reg ulator activity	IDA	molecular_function
GO:0000139	Golgi membrane	IEA	cellular_component
GO:0000165	MAPK cascade	TAS	biological_process
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0000186	activation of MAPKK activ ity	IEA	biological_process
GO:0000902	cell morphogenesis	IEA	biological_process
GO:0001503	ossification	NAS	biological_process
GO:0001892	embryonic placenta develo pment	IEA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001942	hair follicle development	IEA	biological_process
GO:0003682	chromatin binding	IDA	molecular_function
GO:0003690	double-stranded DNA bindi ng	NAS	molecular_function
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0004709	MAP kinase kinase kinase activity	NAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IEA	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IEA	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IMP	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IDA	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	EXP	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IDA	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004714	transmembrane receptor pr otein tyrosine kinase act ivity	IEA	molecular_function
GO:0004714	transmembrane receptor pr otein tyrosine kinase act ivity	IEA	molecular_function
GO:0004714	transmembrane receptor pr otein tyrosine kinase act ivity	TAS	molecular_function
GO:0004716	signal transducer, downst ream of receptor, with pr otein tyrosine kinase act ivity	IEA	molecular_function
GO:0004871	signal transducer activit y	IEA	molecular_function
GO:0004888	transmembrane signaling r eceptor activity	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	IEA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	NAS	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	NAS	molecular_function
GO:0005088	Ras guanyl-nucleotide exc hange factor activity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005615	extracellular space	NAS	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005768	endosome	IEA	cellular_component
GO:0005768	endosome	IEA	cellular_component
GO:0005768	endosome	IDA	cellular_component
GO:0005768	endosome	IDA	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005925	focal adhesion	IDA	cellular_component
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0006950	response to stress	NAS	biological_process
GO:0007165	signal transduction	IEA	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	IDA	biological_process
GO:0007169	transmembrane receptor pr otein tyrosine kinase sig naling pathway	IEA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	IEA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	IDA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	IDA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological_process
GO:0007202	activation of phospholipa se C activity	TAS	biological_process
GO:0007275	multicellular organism de velopment	IEA	biological_process
GO:0007435	salivary gland morphogene sis	IEA	biological_process
GO:0007611	learning or memory	IEA	biological_process
GO:0007611	learning or memory	ISS	biological_process
GO:0008283	cell proliferation	IDA	biological_process
GO:0008284	positive regulation of ce ll proliferation	IEA	biological_process
GO:0008284	positive regulation of ce ll proliferation	IDA	biological_process
GO:0008544	epidermis development	IEA	biological_process
GO:0009986	cell surface	IEA	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0010008	endosome membrane	IEA	cellular_component
GO:0010008	endosome membrane	IDA	cellular_component
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016301	kinase activity	IEA	molecular_function
GO:0016301	kinase activity	IEA	molecular_function
GO:0016310	phosphorylation	IEA	biological_process
GO:0016323	basolateral plasma membra ne	IEA	cellular_component
GO:0016323	basolateral plasma membra ne	IDA	cellular_component
GO:0016337	single organismal cell-ce ll adhesion	IMP	biological_process
GO:0016740	transferase activity	IEA	molecular_function
GO:0018108	peptidyl-tyrosine phospho rylation	IEA	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0019903	protein phosphatase bindi ng	IPI	molecular_function
GO:0021795	cerebral cortex cell migr ation	IEA	biological_process
GO:0030139	endocytic vesicle	IEA	cellular_component
GO:0030307	positive regulation of ce ll growth	IDA	biological_process
GO:0030335	positive regulation of ce ll migration	IMP	biological_process
GO:0031625	ubiquitin protein ligase binding	IPI	molecular_function
GO:0031659	positive regulation of cy clin-dependent protein se rine/threonine kinase act ivity involved in G1/S tr ansition of mitotic cell cycle	IDA	biological_process
GO:0031901	early endosome membrane	IDA	cellular_component
GO:0031965	nuclear membrane	IEA	cellular_component
GO:0035413	positive regulation of ca tenin import into nucleus	IMP	biological_process
GO:0038128	ERBB2 signaling pathway	TAS	biological_process
GO:0042059	negative regulation of ep idermal growth factor rec eptor signaling pathway	TAS	biological_process
GO:0042127	regulation of cell prolif eration	IEA	biological_process
GO:0042177	negative regulation of pr otein catabolic process	IDA	biological_process
GO:0042327	positive regulation of ph osphorylation	IDA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0043006	activation of phospholipa se A2 activity by calcium -mediated signaling	TAS	biological_process
GO:0043066	negative regulation of ap optotic process	IMP	biological_process
GO:0043235	receptor complex	IDA	cellular_component
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043547	positive regulation of GT Pase activity	IEA	biological_process
GO:0045121	membrane raft	IDA	cellular_component
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045739	positive regulation of DN A repair	IDA	biological_process
GO:0045740	positive regulation of DN A replication	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0046777	protein autophosphorylati on	IEA	biological_process
GO:0046777	protein autophosphorylati on	IMP	biological_process
GO:0046854	phosphatidylinositol phos phorylation	IEA	biological_process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IEA	biological_process
GO:0048471	perinuclear region of cyt oplasm	IEA	cellular_component
GO:0048546	digestive tract morphogen esis	IEA	biological_process
GO:0050679	positive regulation of ep ithelial cell proliferati on	IEA	biological_process
GO:0050679	positive regulation of ep ithelial cell proliferati on	IDA	biological_process
GO:0050730	regulation of peptidyl-ty rosine phosphorylation	IEA	biological_process
GO:0050730	regulation of peptidyl-ty rosine phosphorylation	IMP	biological_process
GO:0050999	regulation of nitric-oxid e synthase activity	IDA	biological_process
GO:0051015	actin filament binding	IDA	molecular_function
GO:0051205	protein insertion into me mbrane	TAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0060571	morphogenesis of an epith elial fold	IEA	biological_process
GO:0061029	eyelid development in cam era-type eye	IEA	biological_process
GO:0070141	response to UV-A	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0070435	Shc-EGFR complex	ISS	cellular_component
GO:0071230	cellular response to amin o acid stimulus	IEA	biological_process
GO:0071364	cellular response to epid ermal growth factor stimu lus	IEA	biological_process
GO:0071364	cellular response to epid ermal growth factor stimu lus	ISS	biological_process
GO:0071392	cellular response to estr adiol stimulus	IDA	biological_process
GO:0097489	multivesicular body, inte rnal vesicle lumen	IDA	cellular_component
GO:1903800	positive regulation of pr oduction of miRNAs involv ed in gene silencing by m iRNA	IMP	biological_process
GO:2000145	regulation of cell motili ty	TAS	biological_process
GO:0030122	AP-2 adaptor complex	TAS	cellular_component
GO:0030235	nitric-oxide synthase reg ulator activity	IDA	molecular_function
GO:0000165	MAPK cascade	TAS	biological_process
GO:0001503	ossification	NAS	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0003682	chromatin binding	IDA	molecular_function
GO:0003690	double-stranded DNA bindi ng	NAS	molecular_function
GO:0004709	MAP kinase kinase kinase activity	NAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IMP	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IDA	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	EXP	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	IDA	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004713	protein tyrosine kinase a ctivity	TAS	molecular_function
GO:0004714	transmembrane receptor pr otein tyrosine kinase act ivity	TAS	molecular_function
GO:0004888	transmembrane signaling r eceptor activity	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	IDA	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	NAS	molecular_function
GO:0005006	epidermal growth factor-a ctivated receptor activit y	NAS	molecular_function
GO:0005088	Ras guanyl-nucleotide exc hange factor activity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	NAS	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005768	endosome	IDA	cellular_component
GO:0005768	endosome	IDA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005925	focal adhesion	IDA	cellular_component
GO:0006950	response to stress	NAS	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	IDA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	IDA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	IDA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological_process
GO:0007202	activation of phospholipa se C activity	TAS	biological_process
GO:0007611	learning or memory	ISS	biological_process
GO:0008283	cell proliferation	IDA	biological_process
GO:0008284	positive regulation of ce ll proliferation	IDA	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0010008	endosome membrane	IDA	cellular_component
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0016323	basolateral plasma membra ne	IDA	cellular_component
GO:0016337	single organismal cell-ce ll adhesion	IMP	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0019903	protein phosphatase bindi ng	IPI	molecular_function
GO:0030307	positive regulation of ce ll growth	IDA	biological_process
GO:0030335	positive regulation of ce ll migration	IMP	biological_process
GO:0031625	ubiquitin protein ligase binding	IPI	molecular_function
GO:0031659	positive regulation of cy clin-dependent protein se rine/threonine kinase act ivity involved in G1/S tr ansition of mitotic cell cycle	IDA	biological_process
GO:0031901	early endosome membrane	IDA	cellular_component
GO:0035413	positive regulation of ca tenin import into nucleus	IMP	biological_process
GO:0038128	ERBB2 signaling pathway	TAS	biological_process
GO:0042059	negative regulation of ep idermal growth factor rec eptor signaling pathway	TAS	biological_process
GO:0042177	negative regulation of pr otein catabolic process	IDA	biological_process
GO:0042327	positive regulation of ph osphorylation	IDA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0043006	activation of phospholipa se A2 activity by calcium -mediated signaling	TAS	biological_process
GO:0043066	negative regulation of ap optotic process	IMP	biological_process
GO:0043235	receptor complex	IDA	cellular_component
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0045121	membrane raft	IDA	cellular_component
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045739	positive regulation of DN A repair	IDA	biological_process
GO:0045740	positive regulation of DN A replication	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0046777	protein autophosphorylati on	IMP	biological_process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0050679	positive regulation of ep ithelial cell proliferati on	IDA	biological_process
GO:0050730	regulation of peptidyl-ty rosine phosphorylation	IMP	biological_process
GO:0050999	regulation of nitric-oxid e synthase activity	IDA	biological_process
GO:0051015	actin filament binding	IDA	molecular_function
GO:0051205	protein insertion into me mbrane	TAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0070141	response to UV-A	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0070435	Shc-EGFR complex	ISS	cellular_component
GO:0071364	cellular response to epid ermal growth factor stimu lus	ISS	biological_process
GO:0071392	cellular response to estr adiol stimulus	IDA	biological_process
GO:0097489	multivesicular body, inte rnal vesicle lumen	IDA	cellular_component
GO:1903800	positive regulation of pr oduction of miRNAs involv ed in gene silencing by m iRNA	IMP	biological_process
GO:2000145	regulation of cell motili ty	TAS	biological_process
GO:0030122	AP-2 adaptor complex	TAS	cellular_component
GO:0030235	nitric-oxide synthase reg ulator activity	IDA	molecular_function

KEGG pathways

hsa05200  Pathways in cancer
hsa04151  PI3K-Akt signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa05206  MicroRNAs in cancer
hsa05205  Proteoglycans in cancer
hsa04010  MAPK signaling pathway
hsa04015  Rap1 signaling pathway
hsa04014  Ras signaling pathway
hsa04510  Focal adhesion
hsa05224  Breast cancer
hsa04068  FoxO signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa04144  Endocytosis
PTHR24416:SF91  Cadherin signaling pathway
hsa05215  Prostate cancer
hsa01522  Endocrine resistance
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04066  HIF-1 signaling pathway
hsa05160  Hepatitis C
hsa04072  Phospholipase D signaling pathway
PTHR24416:SF91  EGF receptor signaling pathway
hsa04915  Estrogen signaling pathway
hsa05218  Melanoma
hsa05212  Pancreatic cancer
PTHR24416:SF88  EGF receptor signaling pathway
hsa04012  ErbB signaling pathway
hsa05230  Central carbon metabolism in cancer
hsa04520  Adherens junction
hsa05219  Bladder cancer
hsa04020  Calcium signaling pathway
hsa05231  Choline metabolism in cancer
hsa05214  Glioma
hsa05213  Endometrial cancer
hsa04540  Gap junction
hsa04921  Oxytocin signaling pathway
hsa04912  GnRH signaling pathway
hsa05223  Non-small cell lung cancer
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa04320  Dorso-ventral axis formation
PTHR24416:SF88  Cadherin signaling pathway
PTHR24416:SF90  Cadherin signaling pathway
PTHR24416:SF91  Cadherin signaling pathway
PTHR24416:SF91  Cadherin signaling pathway
PTHR24416:SF90  EGF receptor signaling pathway
PTHR24416:SF88  EGF receptor signaling pathway
PTHR24416:SF137  Cadherin signaling pathway
PTHR24416:SF91  EGF receptor signaling pathway
PTHR24416:SF90  Cadherin signaling pathway
PTHR24416:SF91  EGF receptor signaling pathway
PTHR24416:SF88  Cadherin signaling pathway
PTHR24416:SF137  EGF receptor signaling pathway
PTHR24416:SF90  EGF receptor signaling pathway

Diseases

Associated diseases	References
Adenocarcinoma	OMIM: 131550
Adenomyosis	PMID: 9476071
Asthma	PMID: 17092854
Azoospermia	PMID: 22611165
Bladder cancer	KEGG: H00022
Cardiomyopathy	PMID: 18664296
Cervical cancer	KEGG: H00030
Choriocarcinoma	KEGG: H00028
Chronic obstructive pulmonary disease (COPD)	PMID: 19625176
Cryptorchidism	PMID: 12508124
Decidualization	PMID: 24945252
Endometriosis	PMID: 10871648
Endometriosis	PMID: 18987482
Esophageal cancer	KEGG: H00017
Female infertility	PMID: 23607386
Female infertility	PMID: 25034535
Gastric cancer	KEGG: H00018
Glioma	KEGG: H00042
Hypogonadotropic hypogonadism	PMID: 18591887
Implantation failure	PMID: 18579857
Implantation failure	PMID: 18579857
Kidney disease	PMID: 17303584
Laryngeal cancer	KEGG: H00055
Male infertility	PMID: 1772304
Non-obstructive azoospermia (NOA)	PMID: 11966576
Non-small cell lung cancer	OMIM: 131550
Oral cancer	KEGG: H00016
Oropharyngeal cancer	KEGG: H01559
Ovarian hyperstimulation syndrome (OHSS)	PMID: 11278207
Polycystic kidney disease	PMID: 12653106
Polycystic ovary syndrome (PCOS)	PMID: 22951915
Polycystic ovary syndrome (PCOS)	PMID: 23493574
Polycystic ovaries (PCO)	PMID: 10065863
Prostatic hyperplasia	PMID: 16461080
Psychiatric disorders	PMID: 19086053
Leiomyomas	INFBASE15749523
Endometriosis	INFBASE7962280
Salivary gland cancer	KEGG: H01508
Sertoli cell-only syndrome (SCOS)	PMID: 22611165
Systemic lupus erythematosus	PMID: 15540509
Tubal factor infertility	PMID: 1772304
Tubular damage	PMID: 1772304
Unexplained infertility	PMID: 18579857
Unexplained miscarriages	PMID: 23907942

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Associated_genes	Abstract
10871648	Endometrio sis			115 (36 patient s without endom etriosis, 79 p atients with, e ndometriosis)	EGF EGFR E-cadherin beta-catenin alpha- catenin	Show abstract
21063030	Endometrio sis			63 (19 mild and 44 severe endo metriosis)	EGFR MIR21 DICER1	Show abstract
25658832	Endometrio sis in ova rian cleat r cell car cinoma		Japanes e, Kore an, Ger man	144 samples obt ained from 120 Japanese, 15 Ko rean, 9 German patients with C CC	EGFR	Show abstract
15749523	Endometrio sis	EGFR ( 2073*T)			EGFR	Show abstract
7962280	Endometrio sis			30 (6 eutopic e ndometrium, 10 cyst walls of e ndometriomas, 9 endometriotic implants, 5 pel vic adhesions)	EGF-R	Show abstract
18987482	Endometrio sis			79 (14 endometr ial samples fro m healthy women , 23 samples fr om endometrium, 10 samples fro m endometriomas , 9 samples fro m peritoneal en dometriosis, 23 samples from w omen with endom etriosis)	HER1 HER2 HER3	Show abstract