Endometriosis Knowledgebase

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Gene id

2026

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

ENO2 Gene UCSC Ensembl

Aliases

HEL-S-279, NSE

Gene name

enolase 2

Alternate names

gamma-enolase, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydrolyase, enolase 2 (gamma, neuronal), epididymis secretory protein Li 279, neural enolase, neuron specific gamma enolase, neuron-specific enolase, neuronal enriched enolase, neurone-specifi,

Gene location

12p13.31 (6914449: 6923695) Exons: 12 NC_000012.12

Gene summary(Entrez)

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]

OMIM

131360

Protein Summary

Protein general information

P09104

Name: Gamma enolase (EC 4.2.1.11) (2 phospho D glycerate hydro lyase) (Enolase 2) (Neural enolase) (Neuron specific enolase) (NSE)

Length: 434 Mass: 47,269

Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Sequence

MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAP
ALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAF
NVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALE
LVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDD
WAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGE
TEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL

Structural information

Interpro:	IPR000941 IPR034390 IPR020810 IPR029065 IPR020809 IPR020811 IPR029017
Prosite:	PS00164
Pfam:	PF00113 PF03952
CDD:	cd03313
PDB:	1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ
PDBsum:	1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ
MINT:	1367862
STRING:	ENSP00000229277;

Other Databases

GeneCards: ENO2; Malacards: ENO2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000015	phosphopyruvate hydratase complex	IEA	cellular_component
GO:0000287	magnesium ion binding	IEA	molecular_function
GO:0001917	photoreceptor inner segme nt	IEA	cellular_component
GO:0004634	phosphopyruvate hydratase activity	TAS	molecular_function
GO:0004634	phosphopyruvate hydratase activity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0006094	gluconeogenesis	TAS	biological_process
GO:0043204	perikaryon	IEA	cellular_component
GO:0043209	myelin sheath	IEA	cellular_component
GO:0061621	canonical glycolysis	TAS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0000015	phosphopyruvate hydratase complex	IEA	cellular_component
GO:0000287	magnesium ion binding	IEA	molecular_function
GO:0001917	photoreceptor inner segme nt	IEA	cellular_component
GO:0004634	phosphopyruvate hydratase activity	IEA	molecular_function
GO:0004634	phosphopyruvate hydratase activity	IEA	molecular_function
GO:0004634	phosphopyruvate hydratase activity	TAS	molecular_function
GO:0004634	phosphopyruvate hydratase activity	TAS	molecular_function
GO:0004634	phosphopyruvate hydratase activity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0006094	gluconeogenesis	TAS	biological_process
GO:0006096	glycolytic process	IEA	biological_process
GO:0006096	glycolytic process	IEA	biological_process
GO:0006096	glycolytic process	IEA	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016829	lyase activity	IEA	molecular_function
GO:0043025	neuronal cell body	IEA	cellular_component
GO:0043204	perikaryon	IEA	cellular_component
GO:0043209	myelin sheath	IEA	cellular_component
GO:0046872	metal ion binding	IEA	molecular_function
GO:0061621	canonical glycolysis	TAS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0004634	phosphopyruvate hydratase activity	TAS	molecular_function
GO:0004634	phosphopyruvate hydratase activity	TAS	molecular_function
GO:0004634	phosphopyruvate hydratase activity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006094	gluconeogenesis	TAS	biological_process
GO:0061621	canonical glycolysis	TAS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component

KEGG pathways

hsa01100  Metabolic pathways
hsa04066  HIF-1 signaling pathway
hsa01200  Carbon metabolism
hsa01230  Biosynthesis of amino acids
hsa00010  Glycolysis / Gluconeogenesis
hsa03018  RNA degradation

Diseases

Associated diseases	References
Alzheimer's disease	PMID: 19204726
Cancer	PMID: 19074885
Endometriosis	PMID: 19910323
Endometriosis	INFBASE19910323
Schizophrenia	PMID: 18460190

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
19910323	Endometrio sis			62 (38 premenop ausal women wit h histologicall y diagnosed ova rian endometrio ma or peritonea l endometriosis , 24 women with out endometrios is)		SYN NSE	Show abstract