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A repository for genes associated with endometriosis

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Gene id 2064
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol ERBB2   Gene   UCSC   Ensembl
Aliases CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Gene name erb-b2 receptor tyrosine kinase 2
Alternate names receptor tyrosine-protein kinase erbB-2, c-erb B2/neu protein, herstatin, human epidermal growth factor receptor 2, metastatic lymph node gene 19 protein, neuro/glioblastoma derived oncogene homolog, neuroblastoma/glioblastoma derived oncogene homolog, p185erbB2,
Gene location 17q12 (39688083: 39728661)     Exons: 32     NC_000017.11
Gene summary(Entrez) This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
OMIM 164870

Protein Summary

Protein general information P04626  

Name: Receptor tyrosine protein kinase erbB 2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto oncogene Neu) (Proto oncogene c ErbB 2) (Tyrosine kinase type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)

Length: 1255  Mass: 137,910

Tissue specificity: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO

Sequence MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQ
DIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILK
GGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA
RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI
SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGP
TQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILI
KRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSE
FSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSS
STRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETD
GYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ
GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Structural information
Protein Domains
Protein (720-987)

Motifs
Nuclear localization(676-689)
Interpro:  IPR006211 IPR006212 IPR032778 IPR009030 IPR011009 IPR032675 IPR000719 IPR017441 IPR000494 IPR001245 IPR008266 IPR020635 IPR016245
Prosite:   PS00107 PS50011 PS00109

Pfam:  
PF00757 PF14843 PF07714 PF01030

PDB:  
1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN
PDBsum:   1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN

DIP:  
8
MINT:   158636
STRING:   ENSP00000269571;
Other Databases GeneCards:  ERBB2;  Malacards:  ERBB2

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0000165 MAPK cascade
TAS biological_process
GO:0001042 RNA polymerase I core bin
ding
IDA molecular_function
GO:0001934 positive regulation of pr
otein phosphorylation
ISS biological_process
GO:0004713 protein tyrosine kinase a
ctivity
IDA molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
IGI molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
IDA molecular_function
GO:0004716 signal transducer, downst
ream of receptor, with pr
otein tyrosine kinase act
ivity
IEA molecular_function
GO:0004888 transmembrane signaling r
eceptor activity
IDA molecular_function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005737 cytoplasm
IDA cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0005886 plasma membrane
NAS cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0006351 transcription, DNA-templa
ted
IEA biological_process
GO:0006468 protein phosphorylation
TAS biological_process
GO:0007165 signal transduction
IDA biological_process
GO:0007166 cell surface receptor sig
naling pathway
IDA biological_process
GO:0007167 enzyme linked receptor pr
otein signaling pathway
TAS biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
IDA biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
TAS biological_process
GO:0007422 peripheral nervous system
development
IEA biological_process
GO:0007507 heart development
IEA biological_process
GO:0007528 neuromuscular junction de
velopment
IEA biological_process
GO:0008022 protein C-terminus bindin
g
IPI molecular_function
GO:0008045 motor neuron axon guidanc
e
IEA biological_process
GO:0008283 cell proliferation
TAS biological_process
GO:0010008 endosome membrane
IDA cellular_component
GO:0014065 phosphatidylinositol 3-ki
nase signaling
IDA biological_process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
TAS biological_process
GO:0016021 integral component of mem
brane
NAS cellular_component
GO:0016323 basolateral plasma membra
ne
IDA cellular_component
GO:0016324 apical plasma membrane
IEA cellular_component
GO:0018108 peptidyl-tyrosine phospho
rylation
IEA biological_process
GO:0019903 protein phosphatase bindi
ng
IPI molecular_function
GO:0030307 positive regulation of ce
ll growth
IMP biological_process
GO:0031410 cytoplasmic vesicle
IEA cellular_component
GO:0032886 regulation of microtubule
-based process
IDA biological_process
GO:0033088 negative regulation of im
mature T cell proliferati
on in thymus
IEA biological_process
GO:0038128 ERBB2 signaling pathway
TAS biological_process
GO:0042060 wound healing
IDA biological_process
GO:0042552 myelination
IEA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0043125 ErbB-3 class receptor bin
ding
TAS molecular_function
GO:0043209 myelin sheath
IEA cellular_component
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
TAS cellular_component
GO:0043406 positive regulation of MA
P kinase activity
IDA biological_process
GO:0043547 positive regulation of GT
Pase activity
ISS biological_process
GO:0045727 positive regulation of tr
anslation
IMP biological_process
GO:0045765 regulation of angiogenesi
s
NAS biological_process
GO:0045785 positive regulation of ce
ll adhesion
IDA biological_process
GO:0045943 positive regulation of tr
anscription from RNA poly
merase I promoter
IMP biological_process
GO:0045945 positive regulation of tr
anscription from RNA poly
merase III promoter
IDA biological_process
GO:0046777 protein autophosphorylati
on
IDA biological_process
GO:0046854 phosphatidylinositol phos
phorylation
IEA biological_process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
TAS molecular_function
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0046982 protein heterodimerizatio
n activity
IPI molecular_function
GO:0046983 protein dimerization acti
vity
NAS molecular_function
GO:0048015 phosphatidylinositol-medi
ated signaling
TAS biological_process
GO:0048471 perinuclear region of cyt
oplasm
IEA cellular_component
GO:0048709 oligodendrocyte different
iation
IEA biological_process
GO:0050679 positive regulation of ep
ithelial cell proliferati
on
IDA biological_process
GO:0070372 regulation of ERK1 and ER
K2 cascade
IMP biological_process
GO:0071363 cellular response to grow
th factor stimulus
IDA biological_process
GO:0090314 positive regulation of pr
otein targeting to membra
ne
IDA biological_process
GO:2000145 regulation of cell motili
ty
TAS biological_process
GO:0019838 growth factor binding
IDA molecular_function
GO:0000165 MAPK cascade
TAS biological_process
GO:0000166 nucleotide binding
IEA molecular_function
GO:0001042 RNA polymerase I core bin
ding
IDA molecular_function
GO:0001934 positive regulation of pr
otein phosphorylation
IEA biological_process
GO:0001934 positive regulation of pr
otein phosphorylation
ISS biological_process
GO:0004672 protein kinase activity
IEA molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
IEA molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
IEA molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
IDA molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
IGI molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
IEA molecular_function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
IEA molecular_function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
IDA molecular_function
GO:0004716 signal transducer, downst
ream of receptor, with pr
otein tyrosine kinase act
ivity
IEA molecular_function
GO:0004716 signal transducer, downst
ream of receptor, with pr
otein tyrosine kinase act
ivity
TAS molecular_function
GO:0004888 transmembrane signaling r
eceptor activity
IDA molecular_function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005634 nucleus
IEA cellular_component
GO:0005634 nucleus
IEA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0005737 cytoplasm
IDA cellular_component
GO:0005886 plasma membrane
IEA cellular_component
GO:0005886 plasma membrane
IEA cellular_component
GO:0005886 plasma membrane
IEA cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0005886 plasma membrane
NAS cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0006351 transcription, DNA-templa
ted
IEA biological_process
GO:0006355 regulation of transcripti
on, DNA-templated
IEA biological_process
GO:0006468 protein phosphorylation
IEA biological_process
GO:0006468 protein phosphorylation
TAS biological_process
GO:0007165 signal transduction
IDA biological_process
GO:0007166 cell surface receptor sig
naling pathway
IDA biological_process
GO:0007167 enzyme linked receptor pr
otein signaling pathway
TAS biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
IEA biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
IDA biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
TAS biological_process
GO:0007399 nervous system developmen
t
IEA biological_process
GO:0007422 peripheral nervous system
development
IEA biological_process
GO:0007507 heart development
IEA biological_process
GO:0007528 neuromuscular junction de
velopment
IEA biological_process
GO:0008022 protein C-terminus bindin
g
IPI molecular_function
GO:0008045 motor neuron axon guidanc
e
IEA biological_process
GO:0008283 cell proliferation
TAS biological_process
GO:0010008 endosome membrane
IDA cellular_component
GO:0014065 phosphatidylinositol 3-ki
nase signaling
IDA biological_process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
TAS biological_process
GO:0016020 membrane
IEA cellular_component
GO:0016020 membrane
IEA cellular_component
GO:0016021 integral component of mem
brane
IEA cellular_component
GO:0016021 integral component of mem
brane
IEA cellular_component
GO:0016021 integral component of mem
brane
NAS cellular_component
GO:0016301 kinase activity
IEA molecular_function
GO:0016310 phosphorylation
IEA biological_process
GO:0016323 basolateral plasma membra
ne
IDA cellular_component
GO:0016324 apical plasma membrane
IEA cellular_component
GO:0016740 transferase activity
IEA molecular_function
GO:0018108 peptidyl-tyrosine phospho
rylation
IEA biological_process
GO:0019903 protein phosphatase bindi
ng
IPI molecular_function
GO:0030307 positive regulation of ce
ll growth
IMP biological_process
GO:0031410 cytoplasmic vesicle
IEA cellular_component
GO:0032886 regulation of microtubule
-based process
IDA biological_process
GO:0033088 negative regulation of im
mature T cell proliferati
on in thymus
IEA biological_process
GO:0038128 ERBB2 signaling pathway
TAS biological_process
GO:0042060 wound healing
IDA biological_process
GO:0042552 myelination
IEA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0043125 ErbB-3 class receptor bin
ding
TAS molecular_function
GO:0043209 myelin sheath
IEA cellular_component
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
TAS cellular_component
GO:0043406 positive regulation of MA
P kinase activity
IDA biological_process
GO:0043547 positive regulation of GT
Pase activity
IEA biological_process
GO:0043547 positive regulation of GT
Pase activity
ISS biological_process
GO:0045727 positive regulation of tr
anslation
IMP biological_process
GO:0045765 regulation of angiogenesi
s
NAS biological_process
GO:0045785 positive regulation of ce
ll adhesion
IDA biological_process
GO:0045943 positive regulation of tr
anscription from RNA poly
merase I promoter
IMP biological_process
GO:0045945 positive regulation of tr
anscription from RNA poly
merase III promoter
IDA biological_process
GO:0046777 protein autophosphorylati
on
IDA biological_process
GO:0046854 phosphatidylinositol phos
phorylation
IEA biological_process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
TAS molecular_function
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0046982 protein heterodimerizatio
n activity
IPI molecular_function
GO:0046983 protein dimerization acti
vity
NAS molecular_function
GO:0048015 phosphatidylinositol-medi
ated signaling
TAS biological_process
GO:0048471 perinuclear region of cyt
oplasm
IEA cellular_component
GO:0048709 oligodendrocyte different
iation
IEA biological_process
GO:0050679 positive regulation of ep
ithelial cell proliferati
on
IDA biological_process
GO:0070372 regulation of ERK1 and ER
K2 cascade
IMP biological_process
GO:0071363 cellular response to grow
th factor stimulus
IDA biological_process
GO:0090314 positive regulation of pr
otein targeting to membra
ne
IDA biological_process
GO:2000145 regulation of cell motili
ty
TAS biological_process
GO:0019838 growth factor binding
IDA molecular_function
GO:0000165 MAPK cascade
TAS biological_process
GO:0001042 RNA polymerase I core bin
ding
IDA molecular_function
GO:0001934 positive regulation of pr
otein phosphorylation
ISS biological_process
GO:0004713 protein tyrosine kinase a
ctivity
IDA molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
IGI molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
IDA molecular_function
GO:0004716 signal transducer, downst
ream of receptor, with pr
otein tyrosine kinase act
ivity
TAS molecular_function
GO:0004888 transmembrane signaling r
eceptor activity
IDA molecular_function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005737 cytoplasm
IDA cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0005886 plasma membrane
NAS cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0006468 protein phosphorylation
TAS biological_process
GO:0007165 signal transduction
IDA biological_process
GO:0007166 cell surface receptor sig
naling pathway
IDA biological_process
GO:0007167 enzyme linked receptor pr
otein signaling pathway
TAS biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
IDA biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
TAS biological_process
GO:0008022 protein C-terminus bindin
g
IPI molecular_function
GO:0008283 cell proliferation
TAS biological_process
GO:0010008 endosome membrane
IDA cellular_component
GO:0014065 phosphatidylinositol 3-ki
nase signaling
IDA biological_process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
TAS biological_process
GO:0016021 integral component of mem
brane
NAS cellular_component
GO:0016323 basolateral plasma membra
ne
IDA cellular_component
GO:0019903 protein phosphatase bindi
ng
IPI molecular_function
GO:0030307 positive regulation of ce
ll growth
IMP biological_process
GO:0032886 regulation of microtubule
-based process
IDA biological_process
GO:0038128 ERBB2 signaling pathway
TAS biological_process
GO:0042060 wound healing
IDA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0043125 ErbB-3 class receptor bin
ding
TAS molecular_function
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
TAS cellular_component
GO:0043406 positive regulation of MA
P kinase activity
IDA biological_process
GO:0043547 positive regulation of GT
Pase activity
ISS biological_process
GO:0045727 positive regulation of tr
anslation
IMP biological_process
GO:0045765 regulation of angiogenesi
s
NAS biological_process
GO:0045785 positive regulation of ce
ll adhesion
IDA biological_process
GO:0045943 positive regulation of tr
anscription from RNA poly
merase I promoter
IMP biological_process
GO:0045945 positive regulation of tr
anscription from RNA poly
merase III promoter
IDA biological_process
GO:0046777 protein autophosphorylati
on
IDA biological_process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
TAS molecular_function
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0046982 protein heterodimerizatio
n activity
IPI molecular_function
GO:0046983 protein dimerization acti
vity
NAS molecular_function
GO:0048015 phosphatidylinositol-medi
ated signaling
TAS biological_process
GO:0050679 positive regulation of ep
ithelial cell proliferati
on
IDA biological_process
GO:0070372 regulation of ERK1 and ER
K2 cascade
IMP biological_process
GO:0071363 cellular response to grow
th factor stimulus
IDA biological_process
GO:0090314 positive regulation of pr
otein targeting to membra
ne
IDA biological_process
GO:2000145 regulation of cell motili
ty
TAS biological_process
GO:0019838 growth factor binding
IDA molecular_function

KEGG pathways

hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05205  Proteoglycans in cancer
hsa04510  Focal adhesion
hsa05224  Breast cancer
hsa05215  Prostate cancer
hsa01522  Endocrine resistance
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04066  HIF-1 signaling pathway
hsa05212  Pancreatic cancer
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa05230  Central carbon metabolism in cancer
hsa04520  Adherens junction
hsa05219  Bladder cancer
hsa04020  Calcium signaling pathway
hsa05213  Endometrial cancer
hsa04530  Tight junction
hsa05223  Non-small cell lung cancer

Diseases

Associated diseases References
Bladder cancer KEGG: H00022
Breast cancer KEGG: H00031
Cervical cancer KEGG: H00030
Cholangiocarcinoma KEGG: H00046
Choriocarcinoma KEGG: H00028
Chronic obstructive pulmonary disease (COPD) PMID: 19625176
Cleft lip PMID: 18978678
Endometrial cancer PMID: 12270581
Endometrial cancer KEGG: H00026
Endometriosis PMID: 7650146
Endometriosis PMID: 18987482
Fallopian tube cancer KEGG: H01554
Gastric cancer KEGG: H00018
Ovarian cancer KEGG: H00027
Pancreatic cancer KEGG: H00019
Polycystic ovary syndrome (PCOS) PMID: 26416764
Endometriosis INFBASE18987482
Salivary gland cancer KEGG: H01508
Spermatogenetic defects PMID: 21550039

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
18987482 Endometrio
sis

79 (14 endometr
ial samples fro
m healthy women
, 23 samples fr
om endometrium,
10 samples fro
m endometriomas
, 9 samples fro
m peritoneal en
dometriosis, 23
samples from w
omen with endom
etriosis)
HER1
HER2
HER3
Show abstract