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A repository for genes associated with endometriosis

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Gene id 2065
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol ERBB3   Gene   UCSC   Ensembl
Aliases ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Gene name erb-b2 receptor tyrosine kinase 3
Alternate names receptor tyrosine-protein kinase erbB-3, human epidermal growth factor receptor 3, proto-oncogene-like protein c-ErbB-3, tyrosine kinase-type cell surface receptor HER3, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3,
Gene location 12q13.2 (56080024: 56103506)     Exons: 28     NC_000012.12
Gene summary(Entrez) This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
OMIM 190151

Protein Summary

Protein general information P21860  

Name: Receptor tyrosine protein kinase erbB 3 (EC 2.7.10.1) (Proto oncogene like protein c ErbB 3) (Tyrosine kinase type cell surface receptor HER3)

Length: 1342  Mass: 148,098

Tissue specificity: Epithelial tissues and brain.

Sequence MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLS
FLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIE
KNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQ
CCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS
CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHK
IPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEIS
AGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSR
GGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI
YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKR
AMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGR
QSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYL
EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT
VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRY
LVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSP
SSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPR
PRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM
NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGD
YAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT
Structural information
Protein Domains
Protein (709-966)
Interpro:  IPR006211 IPR006212 IPR032778 IPR009030 IPR011009 IPR032675 IPR000719 IPR000494 IPR001245 IPR016245
Prosite:   PS50011

Pfam:  
PF00757 PF14843 PF07714 PF01030

PDB:  
1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4OTW 4P59 4RIW 4RIX 4RIY 5CUS
PDBsum:   1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4OTW 4P59 4RIW 4RIX 4RIY 5CUS

DIP:  
36441
MINT:   158484
STRING:   ENSP00000267101;
Other Databases GeneCards:  ERBB3;  Malacards:  ERBB3

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0000165 MAPK cascade
TAS biological_process
GO:0003197 endocardial cushion devel
opment
IEA biological_process
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004888 transmembrane signaling r
eceptor activity
ISS molecular_function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005615 extracellular space
IDA cellular_component
GO:0005622 intracellular
IEA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005887 integral component of pla
sma membrane
TAS cellular_component
GO:0007162 negative regulation of ce
ll adhesion
IDA biological_process
GO:0007165 signal transduction
IDA biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
ISS biological_process
GO:0007422 peripheral nervous system
development
ISS biological_process
GO:0007507 heart development
ISS biological_process
GO:0009968 negative regulation of si
gnal transduction
IDA biological_process
GO:0014037 Schwann cell differentiat
ion
ISS biological_process
GO:0014065 phosphatidylinositol 3-ki
nase signaling
IDA biological_process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
TAS biological_process
GO:0014068 positive regulation of ph
osphatidylinositol 3-kina
se signaling
TAS biological_process
GO:0016323 basolateral plasma membra
ne
IDA cellular_component
GO:0016324 apical plasma membrane
IEA cellular_component
GO:0016328 lateral plasma membrane
IEA cellular_component
GO:0018108 peptidyl-tyrosine phospho
rylation
IEA biological_process
GO:0019838 growth factor binding
IPI molecular_function
GO:0019838 growth factor binding
ISS molecular_function
GO:0021545 cranial nerve development
ISS biological_process
GO:0030296 protein tyrosine kinase a
ctivator activity
IDA molecular_function
GO:0038128 ERBB2 signaling pathway
TAS biological_process
GO:0038132 neuregulin binding
IDA molecular_function
GO:0042060 wound healing
NAS biological_process
GO:0042127 regulation of cell prolif
eration
IDA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042803 protein homodimerization
activity
NAS molecular_function
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
ISS cellular_component
GO:0043524 negative regulation of ne
uron apoptotic process
ISS biological_process
GO:0043547 positive regulation of GT
Pase activity
IEA biological_process
GO:0046854 phosphatidylinositol phos
phorylation
IEA biological_process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
TAS molecular_function
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0046982 protein heterodimerizatio
n activity
IPI molecular_function
GO:0048015 phosphatidylinositol-medi
ated signaling
TAS biological_process
GO:0051048 negative regulation of se
cretion
IDA biological_process
GO:0051402 neuron apoptotic process
IMP biological_process
GO:0061098 positive regulation of pr
otein tyrosine kinase act
ivity
IMP biological_process
GO:0070886 positive regulation of ca
lcineurin-NFAT signaling
cascade
IEA biological_process
GO:0097192 extrinsic apoptotic signa
ling pathway in absence o
f ligand
IMP biological_process
GO:2000145 regulation of cell motili
ty
TAS biological_process
GO:0004713 protein tyrosine kinase a
ctivity
IDA molecular_function
GO:0000165 MAPK cascade
TAS biological_process
GO:0000166 nucleotide binding
IEA molecular_function
GO:0003197 endocardial cushion devel
opment
IEA biological_process
GO:0004672 protein kinase activity
IEA molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004888 transmembrane signaling r
eceptor activity
ISS molecular_function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005622 intracellular
IEA cellular_component
GO:0005886 plasma membrane
IEA cellular_component
GO:0005886 plasma membrane
IEA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005887 integral component of pla
sma membrane
TAS cellular_component
GO:0006468 protein phosphorylation
IEA biological_process
GO:0007162 negative regulation of ce
ll adhesion
IDA biological_process
GO:0007165 signal transduction
IDA biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
IEA biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
ISS biological_process
GO:0007422 peripheral nervous system
development
IEA biological_process
GO:0007422 peripheral nervous system
development
ISS biological_process
GO:0007507 heart development
ISS biological_process
GO:0009968 negative regulation of si
gnal transduction
IDA biological_process
GO:0014037 Schwann cell differentiat
ion
IEA biological_process
GO:0014037 Schwann cell differentiat
ion
ISS biological_process
GO:0014065 phosphatidylinositol 3-ki
nase signaling
IDA biological_process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
TAS biological_process
GO:0014068 positive regulation of ph
osphatidylinositol 3-kina
se signaling
TAS biological_process
GO:0016020 membrane
IEA cellular_component
GO:0016020 membrane
IEA cellular_component
GO:0016021 integral component of mem
brane
IEA cellular_component
GO:0016021 integral component of mem
brane
IEA cellular_component
GO:0016301 kinase activity
IEA molecular_function
GO:0016310 phosphorylation
IEA biological_process
GO:0016323 basolateral plasma membra
ne
IDA cellular_component
GO:0016324 apical plasma membrane
IEA cellular_component
GO:0016328 lateral plasma membrane
IEA cellular_component
GO:0016740 transferase activity
IEA molecular_function
GO:0018108 peptidyl-tyrosine phospho
rylation
IEA biological_process
GO:0019838 growth factor binding
IPI molecular_function
GO:0019838 growth factor binding
ISS molecular_function
GO:0021545 cranial nerve development
IEA biological_process
GO:0021545 cranial nerve development
ISS biological_process
GO:0030296 protein tyrosine kinase a
ctivator activity
IDA molecular_function
GO:0038128 ERBB2 signaling pathway
TAS biological_process
GO:0038132 neuregulin binding
IDA molecular_function
GO:0042060 wound healing
NAS biological_process
GO:0042127 regulation of cell prolif
eration
IDA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042803 protein homodimerization
activity
NAS molecular_function
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
ISS cellular_component
GO:0043524 negative regulation of ne
uron apoptotic process
IEA biological_process
GO:0043524 negative regulation of ne
uron apoptotic process
ISS biological_process
GO:0043547 positive regulation of GT
Pase activity
IEA biological_process
GO:0046854 phosphatidylinositol phos
phorylation
IEA biological_process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
TAS molecular_function
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0046982 protein heterodimerizatio
n activity
IPI molecular_function
GO:0048015 phosphatidylinositol-medi
ated signaling
TAS biological_process
GO:0051048 negative regulation of se
cretion
IDA biological_process
GO:0051402 neuron apoptotic process
IMP biological_process
GO:0061098 positive regulation of pr
otein tyrosine kinase act
ivity
IMP biological_process
GO:0070886 positive regulation of ca
lcineurin-NFAT signaling
cascade
IEA biological_process
GO:0097192 extrinsic apoptotic signa
ling pathway in absence o
f ligand
IMP biological_process
GO:2000145 regulation of cell motili
ty
TAS biological_process
GO:0004713 protein tyrosine kinase a
ctivity
IDA molecular_function
GO:0000165 MAPK cascade
TAS biological_process
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004713 protein tyrosine kinase a
ctivity
TAS molecular_function
GO:0004888 transmembrane signaling r
eceptor activity
ISS molecular_function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005615 extracellular space
IDA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005887 integral component of pla
sma membrane
TAS cellular_component
GO:0007162 negative regulation of ce
ll adhesion
IDA biological_process
GO:0007165 signal transduction
IDA biological_process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
ISS biological_process
GO:0007422 peripheral nervous system
development
ISS biological_process
GO:0007507 heart development
ISS biological_process
GO:0009968 negative regulation of si
gnal transduction
IDA biological_process
GO:0014037 Schwann cell differentiat
ion
ISS biological_process
GO:0014065 phosphatidylinositol 3-ki
nase signaling
IDA biological_process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
TAS biological_process
GO:0014068 positive regulation of ph
osphatidylinositol 3-kina
se signaling
TAS biological_process
GO:0016323 basolateral plasma membra
ne
IDA cellular_component
GO:0019838 growth factor binding
IPI molecular_function
GO:0019838 growth factor binding
ISS molecular_function
GO:0021545 cranial nerve development
ISS biological_process
GO:0030296 protein tyrosine kinase a
ctivator activity
IDA molecular_function
GO:0038128 ERBB2 signaling pathway
TAS biological_process
GO:0038132 neuregulin binding
IDA molecular_function
GO:0042060 wound healing
NAS biological_process
GO:0042127 regulation of cell prolif
eration
IDA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0042803 protein homodimerization
activity
NAS molecular_function
GO:0043235 receptor complex
IDA cellular_component
GO:0043235 receptor complex
ISS cellular_component
GO:0043524 negative regulation of ne
uron apoptotic process
ISS biological_process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
TAS molecular_function
GO:0046982 protein heterodimerizatio
n activity
IDA molecular_function
GO:0046982 protein heterodimerizatio
n activity
IPI molecular_function
GO:0048015 phosphatidylinositol-medi
ated signaling
TAS biological_process
GO:0051048 negative regulation of se
cretion
IDA biological_process
GO:0051402 neuron apoptotic process
IMP biological_process
GO:0061098 positive regulation of pr
otein tyrosine kinase act
ivity
IMP biological_process
GO:0097192 extrinsic apoptotic signa
ling pathway in absence o
f ligand
IMP biological_process
GO:2000145 regulation of cell motili
ty
TAS biological_process
GO:0004713 protein tyrosine kinase a
ctivity
IDA molecular_function

KEGG pathways

hsa05206  MicroRNAs in cancer
hsa05205  Proteoglycans in cancer
hsa04144  Endocytosis
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway

Diseases

Associated diseases References
Addison's disease PMID: 18593762
Anti-neutrophil cytoplasmic antibody-associated vasculitis PMID: 19951419
Diabetes KEGG: H00408, PMID: 21829393
Endometrial cancer PMID: 23028188
Endometriosis PMID: 18987482
Multiple sclerosis PMID: 16143043
Polycystic ovary syndrome (PCOS) PMID: 26416764
Endometriosis INFBASE18987482
Schizophrenia PMID: 16958035

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
18987482 Endometrio
sis

79 (14 endometr
ial samples fro
m healthy women
, 23 samples fr
om endometrium,
10 samples fro
m endometriomas
, 9 samples fro
m peritoneal en
dometriosis, 23
samples from w
omen with endom
etriosis)
HER1
HER2
HER3
Show abstract