Search Result
| Gene id | 2147 | ||||||||||||||||||
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| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references | |||||||||||||||||||
Gene Summary |
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| Gene Symbol | F2 Gene UCSC Ensembl | ||||||||||||||||||
| Aliases | PT, RPRGL2, THPH1 | ||||||||||||||||||
| Gene name | coagulation factor II, thrombin | ||||||||||||||||||
| Alternate names | prothrombin, prepro-coagulation factor II, prothrombin B-chain, serine protease, thrombin factor II, | ||||||||||||||||||
| Gene location |
11p11.2 (46719165: 46739507) Exons: 14 NC_000011.10 |
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| Gene summary(Entrez) |
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
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| OMIM | 176930 | ||||||||||||||||||
Protein Summary |
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| Protein general information | P00734 Name: Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] Length: 622 Mass: 70,037 Tissue specificity: Expressed by the liver and secreted in plasma. | ||||||||||||||||||
| Sequence |
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALE SSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGA DLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRL AVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMS PWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIH PRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQV VNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDQFGE | ||||||||||||||||||
| Structural information |
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| Other Databases | GeneCards: F2; Malacards: F2 | ||||||||||||||||||
Gene ontology |
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KEGG pathways
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hsa04610 Complement and coagulation cascades hsa04080 Neuroactive ligand hsa04810 Regulation of actin cytoskeleton | |||||||||||||||||||
Diseases
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PubMed references |
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