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Gene id

2152

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

F3 Gene UCSC Ensembl

Aliases

CD142, TF, TFA

Gene name

coagulation factor III, tissue factor

Alternate names

tissue factor, coagulation factor III (thromboplastin, tissue factor),

Gene location

1p21.3 (94541856: 94529175) Exons: 6 NC_000001.11

Gene summary(Entrez)

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

OMIM

134390

Protein Summary

Protein general information

P13726

Name: Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)

Length: 295 Mass: 33,068

Tissue specificity: Lung, placenta and pancreas. {ECO

Sequence

METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSG
DWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQ
VGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVI
PSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS

Structural information

Motifs	WKS motif(46-48) WKS motif(77-79) WKS motif.(190-192)
Interpro:	IPR003961 IPR013783 IPR015373 IPR001187 IPR030472
Prosite:	PS00621
Pfam:	PF09294 PF01108
PDB:	1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1NL8 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4M7L 4YLQ 4Z6A 4ZMA
PDBsum:	1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1NL8 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4M7L 4YLQ 4Z6A 4ZMA
DIP:	6136
STRING:	ENSP00000334145;

Other Databases

GeneCards: F3; Malacards: F3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001938	positive regulation of en dothelial cell proliferat ion	IDA	biological_process
GO:0002020	protease binding	IPI	molecular_function
GO:0002541	activation of plasma prot eins involved in acute in flammatory response	IDA	biological_process
GO:0002543	activation of blood coagu lation via clotting casca de	IC	biological_process
GO:0004896	cytokine receptor activit y	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005543	phospholipid binding	IDA	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005886	plasma membrane	IBA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological_process
GO:0007568	aging	IEA	biological_process
GO:0007596	blood coagulation	IDA	biological_process
GO:0007598	blood coagulation, extrin sic pathway	TAS	biological_process
GO:0009266	response to temperature s timulus	IEA	biological_process
GO:0009612	response to mechanical st imulus	IEA	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0010641	positive regulation of pl atelet-derived growth fac tor receptor signaling pa thway	IDA	biological_process
GO:0014911	positive regulation of sm ooth muscle cell migratio n	IEA	biological_process
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0019221	cytokine-mediated signali ng pathway	IBA	biological_process
GO:0030335	positive regulation of ce ll migration	TAS	biological_process
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0031233	intrinsic component of ex ternal side of plasma mem brane	IC	cellular_component
GO:0032355	response to estradiol	IEA	biological_process
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0034405	response to fluid shear s tress	IEA	biological_process
GO:0045766	positive regulation of an giogenesis	IDA	biological_process
GO:0050927	positive regulation of po sitive chemotaxis	IC	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0055098	response to low-density l ipoprotein particle	IEA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070301	cellular response to hydr ogen peroxide	IEA	biological_process
GO:0001938	positive regulation of en dothelial cell proliferat ion	IDA	biological_process
GO:0002020	protease binding	IEA	molecular_function
GO:0002020	protease binding	IPI	molecular_function
GO:0002541	activation of plasma prot eins involved in acute in flammatory response	IDA	biological_process
GO:0002543	activation of blood coagu lation via clotting casca de	IC	biological_process
GO:0004896	cytokine receptor activit y	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005543	phospholipid binding	IDA	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005886	plasma membrane	IBA	cellular_component
GO:0005886	plasma membrane	NAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological_process
GO:0007568	aging	IEA	biological_process
GO:0007596	blood coagulation	IEA	biological_process
GO:0007596	blood coagulation	IEA	biological_process
GO:0007596	blood coagulation	IDA	biological_process
GO:0007598	blood coagulation, extrin sic pathway	TAS	biological_process
GO:0007599	hemostasis	IEA	biological_process
GO:0009266	response to temperature s timulus	IEA	biological_process
GO:0009611	response to wounding	IEA	biological_process
GO:0009612	response to mechanical st imulus	IEA	biological_process
GO:0009986	cell surface	IEA	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0010641	positive regulation of pl atelet-derived growth fac tor receptor signaling pa thway	IDA	biological_process
GO:0014911	positive regulation of sm ooth muscle cell migratio n	IEA	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016021	integral component of mem brane	TAS	cellular_component
GO:0019221	cytokine-mediated signali ng pathway	IBA	biological_process
GO:0030335	positive regulation of ce ll migration	TAS	biological_process
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0031233	intrinsic component of ex ternal side of plasma mem brane	IC	cellular_component
GO:0032355	response to estradiol	IEA	biological_process
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0034405	response to fluid shear s tress	IEA	biological_process
GO:0045766	positive regulation of an giogenesis	IDA	biological_process
GO:0050927	positive regulation of po sitive chemotaxis	IC	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0055098	response to low-density l ipoprotein particle	IEA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070301	cellular response to hydr ogen peroxide	IEA	biological_process
GO:0001938	positive regulation of en dothelial cell proliferat ion	IDA	biological_process
GO:0002020	protease binding	IPI	molecular_function
GO:0002541	activation of plasma prot eins involved in acute in flammatory response	IDA	biological_process
GO:0002543	activation of blood coagu lation via clotting casca de	IC	biological_process
GO:0004896	cytokine receptor activit y	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005543	phospholipid binding	IDA	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005886	plasma membrane	IBA	cellular_component
GO:0005886	plasma membrane	NAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological_process
GO:0007596	blood coagulation	IDA	biological_process
GO:0007598	blood coagulation, extrin sic pathway	TAS	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0010641	positive regulation of pl atelet-derived growth fac tor receptor signaling pa thway	IDA	biological_process
GO:0016021	integral component of mem brane	TAS	cellular_component
GO:0019221	cytokine-mediated signali ng pathway	IBA	biological_process
GO:0030335	positive regulation of ce ll migration	TAS	biological_process
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0031233	intrinsic component of ex ternal side of plasma mem brane	IC	cellular_component
GO:0045766	positive regulation of an giogenesis	IDA	biological_process
GO:0050927	positive regulation of po sitive chemotaxis	IC	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IMP	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component

KEGG pathways

hsa04933 AGE-RAGE signaling pathway in diabetic complications
hsa04610 Complement and coagulation cascades

Diseases

Associated diseases	References
Albuminuria	PMID: 17903292
Alzheimer's disease	PMID: 19141999
Atherosclerosis	PMID: 16239598
Diabetes	PMID: 16820938
Endometriosis	PMID: 22672593
Kidney disease	PMID: 19578796
Metabolic syndrome	PMID: 19056482
Polycystic ovary syndrome (PCOS)	PMID: 23900753
Endometriosis	INFBASE22672593

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
22672593	Endometrio sis			62 (42 women wi th ovarian endo metrioma, 20 e ndometrium tiss ues from women without endomet riosis)		TF PAR-2	Show abstract