Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 22943
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol DKK1   Gene   UCSC   Ensembl
Aliases DKK-1, SK
Gene name dickkopf WNT signaling pathway inhibitor 1
Alternate names dickkopf-related protein 1, dickkopf 1 homolog, dickkopf-1 like, dickkopf-like protein 1, hDkk-1,
Gene location 10q21.1 (52314280: 52317656)     Exons: 4     NC_000010.11
Gene summary(Entrez) This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
OMIM 605189

Protein Summary

Protein general information O94907  

Name: Dickkopf related protein 1 (Dickkopf 1) (Dkk 1) (hDkk 1) (SK)

Length: 266  Mass: 28,672

Tissue specificity: Placenta.

Sequence MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQ
TIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEI
EETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRR
KGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
Structural information
Interpro:  IPR006796

Pfam:  
PF04706

PDB:  
3S2K 3S8V 3SOQ 5FWW 5GJE
PDBsum:   3S2K 3S8V 3SOQ 5FWW 5GJE

DIP:  
46461
MINT:   1196808
STRING:   ENSP00000363081;
Other Databases GeneCards:  DKK1;  Malacards:  DKK1

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0000122 negative regulation of tr
anscription from RNA poly
merase II promoter
ISS biological_process
GO:0000122 negative regulation of tr
anscription from RNA poly
merase II promoter
IDA biological_process
GO:0000904 cell morphogenesis involv
ed in differentiation
IEA biological_process
GO:0001706 endoderm formation
IEA biological_process
GO:0001707 mesoderm formation
IEA biological_process
GO:0001942 hair follicle development
IEA biological_process
GO:0002090 regulation of receptor in
ternalization
IDA biological_process
GO:0004871 signal transducer activit
y
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0008083 growth factor activity
TAS molecular_function
GO:0030178 negative regulation of Wn
t signaling pathway
IDA biological_process
GO:0030326 embryonic limb morphogene
sis
IEA biological_process
GO:0030514 negative regulation of BM
P signaling pathway
IEA biological_process
GO:0030900 forebrain development
IEA biological_process
GO:0031901 early endosome membrane
TAS cellular_component
GO:0032091 negative regulation of pr
otein binding
IDA biological_process
GO:0032526 response to retinoic acid
IEA biological_process
GO:0033137 negative regulation of pe
ptidyl-serine phosphoryla
tion
IDA biological_process
GO:0039706 co-receptor binding
IPI molecular_function
GO:0039706 co-receptor binding
IPI molecular_function
GO:0039706 co-receptor binding
TAS molecular_function
GO:0042662 negative regulation of me
sodermal cell fate specif
ication
IDA biological_process
GO:0042663 regulation of endodermal
cell fate specification
IDA biological_process
GO:0048019 receptor antagonist activ
ity
IDA molecular_function
GO:0048642 negative regulation of sk
eletal muscle tissue deve
lopment
IEA biological_process
GO:0050750 low-density lipoprotein p
article receptor binding
IDA molecular_function
GO:0051964 negative regulation of sy
napse assembly
TAS biological_process
GO:0051966 regulation of synaptic tr
ansmission, glutamatergic
IEA biological_process
GO:0060325 face morphogenesis
IEA biological_process
GO:0060394 negative regulation of pa
thway-restricted SMAD pro
tein phosphorylation
IDA biological_process
GO:0061743 motor learning
IEA biological_process
GO:0090082 positive regulation of he
art induction by negative
regulation of canonical
Wnt signaling pathway
ISS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IGI biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
NAS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
TAS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
TAS biological_process
GO:0090244 Wnt signaling pathway inv
olved in somitogenesis
IEA biological_process
GO:1900116 extracellular negative re
gulation of signal transd
uction
IEA biological_process
GO:1901296 negative regulation of ca
nonical Wnt signaling pat
hway involved in cardiac
muscle cell fate commitme
nt
IDA biological_process
GO:1904338 regulation of dopaminergi
c neuron differentiation
TAS biological_process
GO:1904693 midbrain morphogenesis
IEA biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IPI biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IDA biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IDA biological_process
GO:2000726 negative regulation of ca
rdiac muscle cell differe
ntiation
IDA biological_process
GO:0000122 negative regulation of tr
anscription from RNA poly
merase II promoter
IEA biological_process
GO:0000122 negative regulation of tr
anscription from RNA poly
merase II promoter
ISS biological_process
GO:0000122 negative regulation of tr
anscription from RNA poly
merase II promoter
IDA biological_process
GO:0000904 cell morphogenesis involv
ed in differentiation
IEA biological_process
GO:0001706 endoderm formation
IEA biological_process
GO:0001707 mesoderm formation
IEA biological_process
GO:0001942 hair follicle development
IEA biological_process
GO:0002090 regulation of receptor in
ternalization
IDA biological_process
GO:0004871 signal transducer activit
y
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0007275 multicellular organism de
velopment
IEA biological_process
GO:0007275 multicellular organism de
velopment
IEA biological_process
GO:0007492 endoderm development
IEA biological_process
GO:0008083 growth factor activity
TAS molecular_function
GO:0016055 Wnt signaling pathway
IEA biological_process
GO:0030111 regulation of Wnt signali
ng pathway
IEA biological_process
GO:0030178 negative regulation of Wn
t signaling pathway
IEA biological_process
GO:0030178 negative regulation of Wn
t signaling pathway
IEA biological_process
GO:0030178 negative regulation of Wn
t signaling pathway
IDA biological_process
GO:0030326 embryonic limb morphogene
sis
IEA biological_process
GO:0030514 negative regulation of BM
P signaling pathway
IEA biological_process
GO:0030900 forebrain development
IEA biological_process
GO:0031901 early endosome membrane
TAS cellular_component
GO:0032091 negative regulation of pr
otein binding
IDA biological_process
GO:0032526 response to retinoic acid
IEA biological_process
GO:0033137 negative regulation of pe
ptidyl-serine phosphoryla
tion
IDA biological_process
GO:0039706 co-receptor binding
IPI molecular_function
GO:0039706 co-receptor binding
IPI molecular_function
GO:0039706 co-receptor binding
TAS molecular_function
GO:0042662 negative regulation of me
sodermal cell fate specif
ication
IDA biological_process
GO:0042663 regulation of endodermal
cell fate specification
IDA biological_process
GO:0048019 receptor antagonist activ
ity
IDA molecular_function
GO:0048642 negative regulation of sk
eletal muscle tissue deve
lopment
IEA biological_process
GO:0050750 low-density lipoprotein p
article receptor binding
IDA molecular_function
GO:0050807 regulation of synapse org
anization
IEA biological_process
GO:0051964 negative regulation of sy
napse assembly
TAS biological_process
GO:0051966 regulation of synaptic tr
ansmission, glutamatergic
IEA biological_process
GO:0060323 head morphogenesis
IEA biological_process
GO:0060325 face morphogenesis
IEA biological_process
GO:0060394 negative regulation of pa
thway-restricted SMAD pro
tein phosphorylation
IDA biological_process
GO:0061743 motor learning
IEA biological_process
GO:0090082 positive regulation of he
art induction by negative
regulation of canonical
Wnt signaling pathway
IEA biological_process
GO:0090082 positive regulation of he
art induction by negative
regulation of canonical
Wnt signaling pathway
ISS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IEA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IGI biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
NAS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
TAS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
TAS biological_process
GO:0090244 Wnt signaling pathway inv
olved in somitogenesis
IEA biological_process
GO:1900116 extracellular negative re
gulation of signal transd
uction
IEA biological_process
GO:1901296 negative regulation of ca
nonical Wnt signaling pat
hway involved in cardiac
muscle cell fate commitme
nt
IDA biological_process
GO:1904338 regulation of dopaminergi
c neuron differentiation
IEA biological_process
GO:1904338 regulation of dopaminergi
c neuron differentiation
TAS biological_process
GO:1904693 midbrain morphogenesis
IEA biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IPI biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IDA biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IDA biological_process
GO:2000726 negative regulation of ca
rdiac muscle cell differe
ntiation
IDA biological_process
GO:0000122 negative regulation of tr
anscription from RNA poly
merase II promoter
ISS biological_process
GO:0000122 negative regulation of tr
anscription from RNA poly
merase II promoter
IDA biological_process
GO:0002090 regulation of receptor in
ternalization
IDA biological_process
GO:0004871 signal transducer activit
y
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005886 plasma membrane
IDA cellular_component
GO:0008083 growth factor activity
TAS molecular_function
GO:0030178 negative regulation of Wn
t signaling pathway
IDA biological_process
GO:0031901 early endosome membrane
TAS cellular_component
GO:0032091 negative regulation of pr
otein binding
IDA biological_process
GO:0033137 negative regulation of pe
ptidyl-serine phosphoryla
tion
IDA biological_process
GO:0039706 co-receptor binding
IPI molecular_function
GO:0039706 co-receptor binding
IPI molecular_function
GO:0039706 co-receptor binding
TAS molecular_function
GO:0042662 negative regulation of me
sodermal cell fate specif
ication
IDA biological_process
GO:0042663 regulation of endodermal
cell fate specification
IDA biological_process
GO:0048019 receptor antagonist activ
ity
IDA molecular_function
GO:0050750 low-density lipoprotein p
article receptor binding
IDA molecular_function
GO:0051964 negative regulation of sy
napse assembly
TAS biological_process
GO:0060394 negative regulation of pa
thway-restricted SMAD pro
tein phosphorylation
IDA biological_process
GO:0090082 positive regulation of he
art induction by negative
regulation of canonical
Wnt signaling pathway
ISS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IGI biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
IDA biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
NAS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
TAS biological_process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
TAS biological_process
GO:1901296 negative regulation of ca
nonical Wnt signaling pat
hway involved in cardiac
muscle cell fate commitme
nt
IDA biological_process
GO:1904338 regulation of dopaminergi
c neuron differentiation
TAS biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IPI biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IDA biological_process
GO:1904723 negative regulation of Wn
t-Frizzled-LRP5/6 complex
assembly
IDA biological_process
GO:2000726 negative regulation of ca
rdiac muscle cell differe
ntiation
IDA biological_process

KEGG pathways

hsa04310  Wnt signaling pathway

Diseases

Associated diseases References
Alzheimer's disease PMID: 17373700
Asthma PMID: 19926868
Endometriosis PMID: 12810542
Hyperandrogenism PMID: 21611153
Implantation failure PMID: 12810542
Polycystic ovary syndrome (PCOS) PMID: 21611153
Female infertility INFBASE12810542
Implantation defects INFBASE12810542
Endometriosis INFBASE12810542

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
12810542 Endometrio
sis


IL-15
proline-rich protein
B61
Dickkopf-1
glycodelin
N-acetylglucosamine-6-O-sulfotransferase
G0S2 protein
purine nucleoside phosphorylase
semaphorin E
neuronal olfactomedin-related endoplasmic reticulum localized protein mRNA
Sam68-like phospho
Show abstract
22259059 Endometrio
sis



Show abstract