Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 2335
Gene Summary     SNPs    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol FN1   Gene   UCSC   Ensembl
Aliases CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF
Gene name fibronectin 1
Alternate names fibronectin, cold-insoluble globulin, migration-stimulating factor,
Gene location 2q35 (215436166: 215360439)     Exons: 47     NC_000002.12
Gene summary(Entrez) This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
OMIM 135600

SNPs

rs1250248

Strand: +   Allele origin: unknown  Allele change: A/G   Mutation type: snp

  
NC_000002.12   g.215422370A>G
NC_000002.11   g.216287093A>G
NG_012196.1   g.18699T>C
NM_001306132.1   c.1394-127T>C
NM_001306131.1   c.1394-127T>C
NM_001306129.1   c.1394-127T>C
NM_001306130.1   c.1394-127T>C
NM_002026.3   c.1394-127T>C
NM_054034.2   c.1394-127T>C
NM_2124  

Protein Summary

Protein general information P02751  

Name: Fibronectin (FN) (Cold insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl Y1; Ugl Y2; Ugl Y3]

Length: 2386  Mass: 262,625

Tissue specificity: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl

Sequence MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALV
CTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKI
GDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC
TSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCT
TEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQ
NYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITY
NVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGV
VYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGF
RVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDT
SIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYF
KVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSK
YPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGG
EAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTIIPAVPPPTDLRF
TNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPL
RGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYV
VSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSK
STATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVT
TTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKI
AWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAP
TDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLT
SRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQP
GTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVPR
PRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTH
PGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYP
HGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNVIVEAL
KDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSRW
CHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQ
RGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE
Structural information
Protein Domains
Fibronectin (50-90)
Fibronectin (95-138)
Fibronectin (139-182)
Fibronect (184-228)

Motifs
Cell attachment(1524-1526)
Interpro:  IPR000083 IPR003961 IPR000562 IPR013783 IPR013806
Prosite:   PS00022 PS01253 PS51091 PS00023 PS51092 PS50853

Pfam:  
PF00039 PF00040 PF00041
CDD:   cd00062 cd00063

PDB:  
1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J7C
PDBsum:   1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J7C

DIP:  
29547
MINT:   1779779
Other Databases GeneCards:  FN1;  Malacards:  FN1

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001525 angiogenesis
IEA biological_process
GO:0001775 cell activation
IEA biological_process
GO:0001932 regulation of protein pho
sphorylation
IDA biological_process
GO:0002020 protease binding
IPI molecular_function
GO:0002576 platelet degranulation
TAS biological_process
GO:0002931 response to ischemia
IEA biological_process
GO:0005178 integrin binding
IPI molecular_function
GO:0005178 integrin binding
IDA molecular_function
GO:0005178 integrin binding
IMP molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005518 collagen binding
NAS molecular_function
GO:0005576 extracellular region
NAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005577 fibrinogen complex
IDA cellular_component
GO:0005605 basal lamina
IEA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005793 endoplasmic reticulum-Gol
gi intermediate compartme
nt
IDA cellular_component
GO:0006953 acute-phase response
IEA biological_process
GO:0007044 cell-substrate junction a
ssembly
IEA biological_process
GO:0007155 cell adhesion
NAS biological_process
GO:0007161 calcium-independent cell-
matrix adhesion
IEA biological_process
GO:0008201 heparin binding
NAS molecular_function
GO:0008284 positive regulation of ce
ll proliferation
IDA biological_process
GO:0008347 glial cell migration
IEA biological_process
GO:0008360 regulation of cell shape
IEA biological_process
GO:0009611 response to wounding
NAS biological_process
GO:0010193 response to ozone
IEA biological_process
GO:0010628 positive regulation of ge
ne expression
IDA biological_process
GO:0010952 positive regulation of pe
ptidase activity
IEA biological_process
GO:0016324 apical plasma membrane
IEA cellular_component
GO:0016504 peptidase activator activ
ity
IEA molecular_function
GO:0018149 peptide cross-linking
IDA biological_process
GO:0022617 extracellular matrix disa
ssembly
TAS biological_process
GO:0030198 extracellular matrix orga
nization
TAS biological_process
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031093 platelet alpha granule lu
men
TAS cellular_component
GO:0033622 integrin activation
IMP biological_process
GO:0034446 substrate adhesion-depend
ent cell spreading
IDA biological_process
GO:0034446 substrate adhesion-depend
ent cell spreading
IMP biological_process
GO:0035924 cellular response to vasc
ular endothelial growth f
actor stimulus
IEA biological_process
GO:0035987 endodermal cell different
iation
IDA biological_process
GO:0036120 cellular response to plat
elet-derived growth facto
r stimulus
IEA biological_process
GO:0042060 wound healing
IEA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0043066 negative regulation of ap
optotic process
IEA biological_process
GO:0045340 mercury ion binding
IEA molecular_function
GO:0045773 positive regulation of ax
on extension
IEA biological_process
GO:0048146 positive regulation of fi
broblast proliferation
IDA biological_process
GO:0050900 leukocyte migration
TAS biological_process
GO:0050921 positive regulation of ch
emotaxis
IEA biological_process
GO:0051384 response to glucocorticoi
d
IEA biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070372 regulation of ERK1 and ER
K2 cascade
IDA biological_process
GO:0071222 cellular response to lipo
polysaccharide
IEA biological_process
GO:0071288 cellular response to merc
ury ion
IEA biological_process
GO:0071333 cellular response to gluc
ose stimulus
IEA biological_process
GO:0071347 cellular response to inte
rleukin-1
IEA biological_process
GO:0071380 cellular response to pros
taglandin E stimulus
IEA biological_process
GO:0071560 cellular response to tran
sforming growth factor be
ta stimulus
IEA biological_process
GO:0071773 cellular response to BMP
stimulus
IEA biological_process
GO:0072562 blood microparticle
IDA cellular_component
GO:1904237 positive regulation of su
bstrate-dependent cell mi
gration, cell attachment
to substrate
IDA biological_process
GO:2001202 negative regulation of tr
ansforming growth factor-
beta secretion
IDA biological_process
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
ISS cellular_component
GO:0001525 angiogenesis
IEA biological_process
GO:0001775 cell activation
IEA biological_process
GO:0001932 regulation of protein pho
sphorylation
IDA biological_process
GO:0002020 protease binding
IEA molecular_function
GO:0002020 protease binding
IPI molecular_function
GO:0002576 platelet degranulation
TAS biological_process
GO:0002931 response to ischemia
IEA biological_process
GO:0005178 integrin binding
IPI molecular_function
GO:0005178 integrin binding
IDA molecular_function
GO:0005178 integrin binding
IMP molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005518 collagen binding
NAS molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
NAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005577 fibrinogen complex
IDA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
IEA cellular_component
GO:0005604 basement membrane
IEA cellular_component
GO:0005605 basal lamina
IEA cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005793 endoplasmic reticulum-Gol
gi intermediate compartme
nt
IDA cellular_component
GO:0006953 acute-phase response
IEA biological_process
GO:0007044 cell-substrate junction a
ssembly
IEA biological_process
GO:0007155 cell adhesion
IEA biological_process
GO:0007155 cell adhesion
IEA biological_process
GO:0007155 cell adhesion
NAS biological_process
GO:0007160 cell-matrix adhesion
IEA biological_process
GO:0007161 calcium-independent cell-
matrix adhesion
IEA biological_process
GO:0008201 heparin binding
IEA molecular_function
GO:0008201 heparin binding
NAS molecular_function
GO:0008284 positive regulation of ce
ll proliferation
IDA biological_process
GO:0008347 glial cell migration
IEA biological_process
GO:0008360 regulation of cell shape
IEA biological_process
GO:0009611 response to wounding
IEA biological_process
GO:0009611 response to wounding
NAS biological_process
GO:0010193 response to ozone
IEA biological_process
GO:0010628 positive regulation of ge
ne expression
IDA biological_process
GO:0010952 positive regulation of pe
ptidase activity
IEA biological_process
GO:0016324 apical plasma membrane
IEA cellular_component
GO:0016504 peptidase activator activ
ity
IEA molecular_function
GO:0018149 peptide cross-linking
IDA biological_process
GO:0022617 extracellular matrix disa
ssembly
TAS biological_process
GO:0030198 extracellular matrix orga
nization
IEA biological_process
GO:0030198 extracellular matrix orga
nization
TAS biological_process
GO:0030335 positive regulation of ce
ll migration
IEA biological_process
GO:0031012 extracellular matrix
IEA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031093 platelet alpha granule lu
men
TAS cellular_component
GO:0033622 integrin activation
IMP biological_process
GO:0034446 substrate adhesion-depend
ent cell spreading
IDA biological_process
GO:0034446 substrate adhesion-depend
ent cell spreading
IMP biological_process
GO:0035924 cellular response to vasc
ular endothelial growth f
actor stimulus
IEA biological_process
GO:0035987 endodermal cell different
iation
IDA biological_process
GO:0036120 cellular response to plat
elet-derived growth facto
r stimulus
IEA biological_process
GO:0042060 wound healing
IEA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0043066 negative regulation of ap
optotic process
IEA biological_process
GO:0045340 mercury ion binding
IEA molecular_function
GO:0045773 positive regulation of ax
on extension
IEA biological_process
GO:0048146 positive regulation of fi
broblast proliferation
IDA biological_process
GO:0050900 leukocyte migration
TAS biological_process
GO:0050921 positive regulation of ch
emotaxis
IEA biological_process
GO:0051384 response to glucocorticoi
d
IEA biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070372 regulation of ERK1 and ER
K2 cascade
IDA biological_process
GO:0071222 cellular response to lipo
polysaccharide
IEA biological_process
GO:0071288 cellular response to merc
ury ion
IEA biological_process
GO:0071333 cellular response to gluc
ose stimulus
IEA biological_process
GO:0071347 cellular response to inte
rleukin-1
IEA biological_process
GO:0071380 cellular response to pros
taglandin E stimulus
IEA biological_process
GO:0071560 cellular response to tran
sforming growth factor be
ta stimulus
IEA biological_process
GO:0071773 cellular response to BMP
stimulus
IEA biological_process
GO:0072562 blood microparticle
IDA cellular_component
GO:1904237 positive regulation of su
bstrate-dependent cell mi
gration, cell attachment
to substrate
IDA biological_process
GO:2001202 negative regulation of tr
ansforming growth factor-
beta secretion
IDA biological_process
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
ISS cellular_component
GO:0001932 regulation of protein pho
sphorylation
IDA biological_process
GO:0002020 protease binding
IPI molecular_function
GO:0002576 platelet degranulation
TAS biological_process
GO:0005178 integrin binding
IPI molecular_function
GO:0005178 integrin binding
IDA molecular_function
GO:0005178 integrin binding
IMP molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005518 collagen binding
NAS molecular_function
GO:0005576 extracellular region
NAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005577 fibrinogen complex
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005793 endoplasmic reticulum-Gol
gi intermediate compartme
nt
IDA cellular_component
GO:0007155 cell adhesion
NAS biological_process
GO:0008201 heparin binding
NAS molecular_function
GO:0008284 positive regulation of ce
ll proliferation
IDA biological_process
GO:0009611 response to wounding
NAS biological_process
GO:0010628 positive regulation of ge
ne expression
IDA biological_process
GO:0018149 peptide cross-linking
IDA biological_process
GO:0022617 extracellular matrix disa
ssembly
TAS biological_process
GO:0030198 extracellular matrix orga
nization
TAS biological_process
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031093 platelet alpha granule lu
men
TAS cellular_component
GO:0033622 integrin activation
IMP biological_process
GO:0034446 substrate adhesion-depend
ent cell spreading
IDA biological_process
GO:0034446 substrate adhesion-depend
ent cell spreading
IMP biological_process
GO:0035987 endodermal cell different
iation
IDA biological_process
GO:0042802 identical protein binding
IPI molecular_function
GO:0042802 identical protein binding
IPI molecular_function
GO:0048146 positive regulation of fi
broblast proliferation
IDA biological_process
GO:0050900 leukocyte migration
TAS biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070372 regulation of ERK1 and ER
K2 cascade
IDA biological_process
GO:0072562 blood microparticle
IDA cellular_component
GO:1904237 positive regulation of su
bstrate-dependent cell mi
gration, cell attachment
to substrate
IDA biological_process
GO:2001202 negative regulation of tr
ansforming growth factor-
beta secretion
IDA biological_process
GO:0031012 extracellular matrix
IDA cellular_component
GO:0031012 extracellular matrix
ISS cellular_component

KEGG pathways

hsa05200  Pathways in cancer
hsa04151  PI3K-Akt signaling pathway
hsa05205  Proteoglycans in cancer
hsa04510  Focal adhesion
hsa04810  Regulation of actin cytoskeleton
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05146  Amoebiasis
hsa05222  Small cell lung cancer
hsa04512  ECM-receptor interaction
hsa05100  Bacterial invasion of epithelial cells

Diseases

Associated diseases References
Asthenozoospermia PMID: 21848911
Cancer PMID: 19730683
Coronary artery disease PMID: 16375583
Cryoglobulinemia PMID: 18810851
Endometriosis PMID: 9022601
Glomerulopathy KEGG: H01260, OMIM: 135600
Leucocytospermia PMID: 23920130
Male infertility PMID: 7639343
Nephrolithiasis PMID: 19616291
Plasma fibronectin deficiency OMIM: 135600
Female infertility INFBASE11841847
Endometriosis INFBASE11841847
Schizophrenia PMID: 12497612
Systemic sclerosis PMID: 9870923

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
23142796 Endometrio
sis
CDKN2BAS rs1333049, rs7521902 close to WNT4, rs12700667 in an inter-genic region on 7p15.2 and fibronectin 1 rs1250248
3015 (305 endom
etriosis patien
ts and 2710 con
trols)
CDKN2BAS
WNT4
fibronectin 1
Show abstract
11841847 Endometrio
sis


Female infertility Collagen IV (C-IV)
elastin
CD4
CD8
CD29
CD45RO and fibronectin (Fn)
Show abstract
24676469 Endometrio
sis
rs12700667, rs7521902, rs10859871, rs1537377, rs7739264, rs13394619, rs1250248, rs4141819, rs4141819 and rs6734792 Austral
ia, Bel
gium, I
taly, U
K, USA,
Japan
44184 (11 506 c
ases, 32 678 co
ntrols)
Female infertility
Show abstract
23315067 Endometrio
sis
rs1250248, rs12700667, rs7798431 and rs7521902 Caucasi
an
1960 (1129 pati
ents with endom
etriosis, 831 c
ontrols)

Show abstract