Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 2353
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol FOS   Gene   UCSC   Ensembl
Aliases AP-1, C-FOS, p55
Gene name Fos proto-oncogene, AP-1 transcription factor subunit
Alternate names proto-oncogene c-Fos, FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS), FBJ murine osteosarcoma viral oncogene homolog, Fos proto-oncogene, AP-1 trancription factor subunit, G0/G1 switch regulatory protein 7, activator protein 1, cellular o,
Gene location 14q24.3 (75278777: 75282233)     Exons: 4     NC_000014.9
Gene summary(Entrez) The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
OMIM 164810

Protein Summary

Protein general information P01100  

Name: Proto oncogene c Fos (Cellular oncogene fos) (G0/G1 switch regulatory protein 7)

Length: 380  Mass: 40,695

Sequence MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQW
LVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMA
AAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTG
GLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSP
TLLAL
Structural information
Protein Domains
bZIP. (137-200)
Interpro:  IPR000837 IPR004827 IPR029816
Prosite:   PS50217 PS00036

Pfam:  
PF00170

PDB:  
1A02 1FOS 1S9K
PDBsum:   1A02 1FOS 1S9K

DIP:  
1047
MINT:   105814
STRING:   ENSP00000306245;
Other Databases GeneCards:  FOS;  Malacards:  FOS

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0000978 RNA polymerase II core pr
omoter proximal region se
quence-specific DNA bindi
ng
IBA molecular_function
GO:0000979 RNA polymerase II core pr
omoter sequence-specific
DNA binding
IEA molecular_function
GO:0000982 transcription factor acti
vity, RNA polymerase II c
ore promoter proximal reg
ion sequence-specific bin
ding
IBA molecular_function
GO:0001077 transcriptional activator
activity, RNA polymerase
II core promoter proxima
l region sequence-specifi
c binding
IEA molecular_function
GO:0001661 conditioned taste aversio
n
IEA biological_process
GO:0003682 chromatin binding
IEA molecular_function
GO:0003700 transcription factor acti
vity, sequence-specific D
NA binding
IDA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005634 nucleus
IDA cellular_component
GO:0005654 nucleoplasm
IDA cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005667 transcription factor comp
lex
IEA cellular_component
GO:0005783 endoplasmic reticulum
IEA cellular_component
GO:0005829 cytosol
IEA cellular_component
GO:0006306 DNA methylation
TAS biological_process
GO:0006357 regulation of transcripti
on from RNA polymerase II
promoter
TAS biological_process
GO:0006366 transcription from RNA po
lymerase II promoter
IEA biological_process
GO:0006954 inflammatory response
TAS biological_process
GO:0007179 transforming growth facto
r beta receptor signaling
pathway
IDA biological_process
GO:0007399 nervous system developmen
t
IEA biological_process
GO:0007565 female pregnancy
IEA biological_process
GO:0007568 aging
IEA biological_process
GO:0008134 transcription factor bind
ing
IPI molecular_function
GO:0009409 response to cold
IEA biological_process
GO:0009416 response to light stimulu
s
IEA biological_process
GO:0009629 response to gravity
IEA biological_process
GO:0009636 response to toxic substan
ce
IEA biological_process
GO:0016020 membrane
IEA cellular_component
GO:0030431 sleep
IEA biological_process
GO:0031668 cellular response to extr
acellular stimulus
IEA biological_process
GO:0032496 response to lipopolysacch
aride
IEA biological_process
GO:0032570 response to progesterone
IEA biological_process
GO:0032870 cellular response to horm
one stimulus
IEA biological_process
GO:0034097 response to cytokine
IEA biological_process
GO:0034614 cellular response to reac
tive oxygen species
IDA biological_process
GO:0035902 response to immobilizatio
n stress
IEA biological_process
GO:0035914 skeletal muscle cell diff
erentiation
IEA biological_process
GO:0035994 response to muscle stretc
h
IEA biological_process
GO:0038095 Fc-epsilon receptor signa
ling pathway
TAS biological_process
GO:0042493 response to drug
IEA biological_process
GO:0043005 neuron projection
IEA cellular_component
GO:0044212 transcription regulatory
region DNA binding
IDA molecular_function
GO:0045672 positive regulation of os
teoclast differentiation
IEA biological_process
GO:0045893 positive regulation of tr
anscription, DNA-template
d
IDA biological_process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
IGI biological_process
GO:0046982 protein heterodimerizatio
n activity
IEA molecular_function
GO:0051090 regulation of sequence-sp
ecific DNA binding transc
ription factor activity
TAS biological_process
GO:0051412 response to corticosteron
e
IEA biological_process
GO:0051591 response to cAMP
IEA biological_process
GO:0060395 SMAD protein signal trans
duction
IDA biological_process
GO:0070412 R-SMAD binding
IPI molecular_function
GO:0071277 cellular response to calc
ium ion
IEA biological_process
GO:1902895 positive regulation of pr
i-miRNA transcription fro
m RNA polymerase II promo
ter
ISS biological_process
GO:0000978 RNA polymerase II core pr
omoter proximal region se
quence-specific DNA bindi
ng
IEA molecular_function
GO:0000978 RNA polymerase II core pr
omoter proximal region se
quence-specific DNA bindi
ng
IBA molecular_function
GO:0000979 RNA polymerase II core pr
omoter sequence-specific
DNA binding
IEA molecular_function
GO:0000982 transcription factor acti
vity, RNA polymerase II c
ore promoter proximal reg
ion sequence-specific bin
ding
IBA molecular_function
GO:0001077 transcriptional activator
activity, RNA polymerase
II core promoter proxima
l region sequence-specifi
c binding
IEA molecular_function
GO:0001661 conditioned taste aversio
n
IEA biological_process
GO:0003677 DNA binding
IEA molecular_function
GO:0003677 DNA binding
IEA molecular_function
GO:0003677 DNA binding
IEA molecular_function
GO:0003682 chromatin binding
IEA molecular_function
GO:0003690 double-stranded DNA bindi
ng
IEA molecular_function
GO:0003700 transcription factor acti
vity, sequence-specific D
NA binding
IEA molecular_function
GO:0003700 transcription factor acti
vity, sequence-specific D
NA binding
IEA molecular_function
GO:0003700 transcription factor acti
vity, sequence-specific D
NA binding
IDA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005634 nucleus
IEA cellular_component
GO:0005634 nucleus
IEA cellular_component
GO:0005634 nucleus
IEA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
TAS cellular_component
GO:0005654 nucleoplasm
IDA cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005667 transcription factor comp
lex
IEA cellular_component
GO:0005667 transcription factor comp
lex
IEA cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0005783 endoplasmic reticulum
IEA cellular_component
GO:0005783 endoplasmic reticulum
IEA cellular_component
GO:0005829 cytosol
IEA cellular_component
GO:0006306 DNA methylation
TAS biological_process
GO:0006355 regulation of transcripti
on, DNA-templated
IEA biological_process
GO:0006355 regulation of transcripti
on, DNA-templated
IEA biological_process
GO:0006357 regulation of transcripti
on from RNA polymerase II
promoter
IEA biological_process
GO:0006357 regulation of transcripti
on from RNA polymerase II
promoter
TAS biological_process
GO:0006366 transcription from RNA po
lymerase II promoter
IEA biological_process
GO:0006366 transcription from RNA po
lymerase II promoter
TAS biological_process
GO:0006954 inflammatory response
TAS biological_process
GO:0007179 transforming growth facto
r beta receptor signaling
pathway
IDA biological_process
GO:0007399 nervous system developmen
t
IEA biological_process
GO:0007565 female pregnancy
IEA biological_process
GO:0007568 aging
IEA biological_process
GO:0008134 transcription factor bind
ing
IEA molecular_function
GO:0008134 transcription factor bind
ing
IPI molecular_function
GO:0009409 response to cold
IEA biological_process
GO:0009416 response to light stimulu
s
IEA biological_process
GO:0009612 response to mechanical st
imulus
IEA biological_process
GO:0009629 response to gravity
IEA biological_process
GO:0009636 response to toxic substan
ce
IEA biological_process
GO:0014070 response to organic cycli
c compound
IEA biological_process
GO:0016020 membrane
IEA cellular_component
GO:0030431 sleep
IEA biological_process
GO:0031668 cellular response to extr
acellular stimulus
IEA biological_process
GO:0032496 response to lipopolysacch
aride
IEA biological_process
GO:0032570 response to progesterone
IEA biological_process
GO:0032870 cellular response to horm
one stimulus
IEA biological_process
GO:0034097 response to cytokine
IEA biological_process
GO:0034614 cellular response to reac
tive oxygen species
IDA biological_process
GO:0035902 response to immobilizatio
n stress
IEA biological_process
GO:0035914 skeletal muscle cell diff
erentiation
IEA biological_process
GO:0035994 response to muscle stretc
h
IEA biological_process
GO:0038095 Fc-epsilon receptor signa
ling pathway
TAS biological_process
GO:0042493 response to drug
IEA biological_process
GO:0043005 neuron projection
IEA cellular_component
GO:0043565 sequence-specific DNA bin
ding
IEA molecular_function
GO:0043565 sequence-specific DNA bin
ding
IEA molecular_function
GO:0044212 transcription regulatory
region DNA binding
IDA molecular_function
GO:0045672 positive regulation of os
teoclast differentiation
IEA biological_process
GO:0045893 positive regulation of tr
anscription, DNA-template
d
IDA biological_process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
IEA biological_process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
IGI biological_process
GO:0046982 protein heterodimerizatio
n activity
IEA molecular_function
GO:0051090 regulation of sequence-sp
ecific DNA binding transc
ription factor activity
TAS biological_process
GO:0051412 response to corticosteron
e
IEA biological_process
GO:0051591 response to cAMP
IEA biological_process
GO:0060395 SMAD protein signal trans
duction
IDA biological_process
GO:0070412 R-SMAD binding
IPI molecular_function
GO:0071277 cellular response to calc
ium ion
IEA biological_process
GO:1902895 positive regulation of pr
i-miRNA transcription fro
m RNA polymerase II promo
ter
IEA biological_process
GO:1902895 positive regulation of pr
i-miRNA transcription fro
m RNA polymerase II promo
ter
ISS biological_process
GO:0000978 RNA polymerase II core pr
omoter proximal region se
quence-specific DNA bindi
ng
IBA molecular_function
GO:0000982 transcription factor acti
vity, RNA polymerase II c
ore promoter proximal reg
ion sequence-specific bin
ding
IBA molecular_function
GO:0003700 transcription factor acti
vity, sequence-specific D
NA binding
IDA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
TAS cellular_component
GO:0005654 nucleoplasm
IDA cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0006306 DNA methylation
TAS biological_process
GO:0006357 regulation of transcripti
on from RNA polymerase II
promoter
TAS biological_process
GO:0006366 transcription from RNA po
lymerase II promoter
TAS biological_process
GO:0006954 inflammatory response
TAS biological_process
GO:0007179 transforming growth facto
r beta receptor signaling
pathway
IDA biological_process
GO:0008134 transcription factor bind
ing
IPI molecular_function
GO:0034614 cellular response to reac
tive oxygen species
IDA biological_process
GO:0038095 Fc-epsilon receptor signa
ling pathway
TAS biological_process
GO:0044212 transcription regulatory
region DNA binding
IDA molecular_function
GO:0045893 positive regulation of tr
anscription, DNA-template
d
IDA biological_process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
IGI biological_process
GO:0051090 regulation of sequence-sp
ecific DNA binding transc
ription factor activity
TAS biological_process
GO:0060395 SMAD protein signal trans
duction
IDA biological_process
GO:0070412 R-SMAD binding
IPI molecular_function
GO:1902895 positive regulation of pr
i-miRNA transcription fro
m RNA polymerase II promo
ter
ISS biological_process

KEGG pathways

PTHR23351:SF4  CCKR signaling map
hsa05200  Pathways in cancer
hsa05166  HTLV-I infection
hsa04010  MAPK signaling pathway
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex infection
hsa05418  Fluid shear stress and atherosclerosis
hsa05161  Hepatitis B
PTHR23351:SF4  Apoptosis signaling pathway
hsa05224  Breast cancer
PTHR23351:SF4  CCKR signaling map
hsa04210  Apoptosis
hsa04659  Th17 cell differentiation
hsa04668  TNF signaling pathway
hsa05142  Chagas disease
PTHR23351:SF4  T cell activation
hsa01522  Endocrine resistance
hsa04657  IL-17 signaling pathway
hsa04380  Osteoclast differentiation
hsa04024  cAMP signaling pathway
PTHR23351:SF4  T cell activation
hsa05323  Rheumatoid arthritis
hsa04620  Toll-like receptor signaling pathway
PTHR23351:SF4  B cell activation
hsa04660  T cell receptor signaling pathway
hsa04915  Estrogen signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa05140  Leishmaniasis
hsa04917  Prolactin signaling pathway
hsa05133  Pertussis
hsa05210  Colorectal cancer
hsa05132  Salmonella infection
hsa05231  Choline metabolism in cancer
PTHR23351:SF4  CCKR signaling map
hsa04921  Oxytocin signaling pathway
PTHR23351:SF4  B cell activation
PTHR23351:SF4  B cell activation
hsa04725  Cholinergic synapse
hsa04662  B cell receptor signaling pathway
hsa04728  Dopaminergic synapse
PTHR23351:SF4  T cell activation
PTHR23351:SF4  T cell activation
hsa04713  Circadian entrainment
hsa05031  Amphetamine addiction
PTHR23351:SF4  Apoptosis signaling pathway
PTHR23351:SF4  B cell activation
PTHR23351:SF4  CCKR signaling map
PTHR23351:SF4  T cell activation
PTHR23351:SF4  CCKR signaling map
PTHR23351:SF4  CCKR signaling map
PTHR23351:SF4  CCKR signaling map
PTHR23351:SF4  Apoptosis signaling pathway
PTHR23351:SF4  B cell activation
PTHR23351:SF4  Apoptosis signaling pathway
PTHR23351:SF4  Apoptosis signaling pathway

Diseases

Associated diseases References
Alzheimer's disease PMID: 9014232
Cancer PMID: 19692168
Chronic obstructive pulmonary disease (COPD) PMID: 19625176
Endometriosis PMID: 19199093
Hyperandrogenism PMID: 22723319
Polycystic ovary syndrome (PCOS) PMID: 22723319
Endometriosis INFBASE17888430

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
19199093 Endometrio
sis

34 (15 infertil
e women with en
dometriosis, 19
control infert
ile women)
Female infertility
Show abstract
17888430 Endometrio
sis

55 (25 with end
ometriosis, 30
without endomet
riosis)
c-fos
MMP-9
Show abstract