Endometriosis Knowledgebase

Search Result

Gene id

2621

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

GAS6 Gene UCSC Ensembl

Aliases

AXLLG, AXSF

Gene name

growth arrest specific 6

Alternate names

growth arrest-specific protein 6, AXL receptor tyrosine kinase ligand, AXL stimulatory factor,

Gene location

13q34 (113864102: 113820548) Exons: 15 NC_000013.11

Gene summary(Entrez)

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

OMIM

600441

Protein Summary

Protein general information

Q14393

Name: Growth arrest specific protein 6 (GAS 6) (AXL receptor tyrosine kinase ligand)

Length: 721 Mass: 79,677

Tissue specificity: Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. {ECO

Sequence

MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEA
REVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGG
RLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDE
GFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCELEAGWPCPRHRRDGSPAARPGR
GAQGSRSEGHIPDRRGPRPWQDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEG
ILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAG
DLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPG
SGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAV
EHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVT
SAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA

Structural information

Protein Domains	Gla. (53-94) EGF-like (116-154) ({ECO:0000255\|PROSITE-ProRule:PRU00076}-) EGF-like (156-196) ({ECO:0000255\|PROSITE-ProRule:PRU00076}-) EGF-like (197-237)
Interpro:	IPR026823 IPR017857 IPR013320 IPR001881 IPR013032 IPR000742 IPR000152 IPR018097 IPR000294 IPR009030 IPR001791
Prosite:	PS00010 PS00022 PS01186 PS50026 PS01187 PS00011 PS50998 PS50025
Pfam:	PF12662 PF07645 PF00594 PF12661 PF00054 PF02210
PDB:	1H30 2C5D 4RA0
PDBsum:	1H30 2C5D 4RA0
MINT:	2735698

Other Databases

GeneCards: GAS6; Malacards: GAS6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001764	neuron migration	IEA	biological_process
GO:0001786	phosphatidylserine bindin g	IDA	molecular_function
GO:0001934	positive regulation of pr otein phosphorylation	ISS	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001961	positive regulation of cy tokine-mediated signaling pathway	IMP	biological_process
GO:0002576	platelet degranulation	TAS	biological_process
GO:0003104	positive regulation of gl omerular filtration	ISS	biological_process
GO:0005102	receptor binding	IDA	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005245	voltage-gated calcium cha nnel activity	IDA	molecular_function
GO:0005509	calcium ion binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005788	endoplasmic reticulum lum en	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0006465	signal peptide processing	TAS	biological_process
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0006888	ER to Golgi vesicle-media ted transport	TAS	biological_process
GO:0006909	phagocytosis	IDA	biological_process
GO:0007050	cell cycle arrest	TAS	biological_process
GO:0007155	cell adhesion	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0007167	enzyme linked receptor pr otein signaling pathway	IEA	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0009267	cellular response to star vation	IEA	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010804	negative regulation of tu mor necrosis factor-media ted signaling pathway	IDA	biological_process
GO:0010934	macrophage cytokine produ ction	IEA	biological_process
GO:0016477	cell migration	TAS	biological_process
GO:0018105	peptidyl-serine phosphory lation	IDA	biological_process
GO:0018105	peptidyl-serine phosphory lation	IDA	biological_process
GO:0019064	fusion of virus membrane with host plasma membrane	IDA	biological_process
GO:0019079	viral genome replication	IDA	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0030296	protein tyrosine kinase a ctivator activity	IDA	molecular_function
GO:0030971	receptor tyrosine kinase binding	IPI	molecular_function
GO:0031093	platelet alpha granule lu men	TAS	cellular_component
GO:0031100	animal organ regeneration	IEA	biological_process
GO:0031589	cell-substrate adhesion	IEA	biological_process
GO:0032008	positive regulation of TO R signaling	ISS	biological_process
GO:0032148	activation of protein kin ase B activity	ISS	biological_process
GO:0032689	negative regulation of in terferon-gamma production	IDA	biological_process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032825	positive regulation of na tural killer cell differe ntiation	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033159	negative regulation of pr otein import into nucleus , translocation	IDA	biological_process
GO:0035457	cellular response to inte rferon-alpha	IDA	biological_process
GO:0035690	cellular response to drug	IDA	biological_process
GO:0035754	B cell chemotaxis	IDA	biological_process
GO:0040008	regulation of growth	IEA	biological_process
GO:0043027	cysteine-type endopeptida se inhibitor activity inv olved in apoptotic proces s	IDA	molecular_function
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043277	apoptotic cell clearance	IDA	biological_process
GO:0043433	negative regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological_process
GO:0043491	protein kinase B signalin g	IDA	biological_process
GO:0043491	protein kinase B signalin g	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0046718	viral entry into host cel l	IDA	biological_process
GO:0046813	receptor-mediated virion attachment to host cell	IDA	biological_process
GO:0046827	positive regulation of pr otein export from nucleus	IDA	biological_process
GO:0048018	receptor agonist activity	IDA	molecular_function
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0050711	negative regulation of in terleukin-1 secretion	IDA	biological_process
GO:0050766	positive regulation of ph agocytosis	IDA	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060090	binding, bridging	IDA	molecular_function
GO:0061098	positive regulation of pr otein tyrosine kinase act ivity	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070168	negative regulation of bi omineral tissue developme nt	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070527	platelet aggregation	TAS	biological_process
GO:0070588	calcium ion transmembrane transport	IDA	biological_process
GO:0071307	cellular response to vita min K	IDA	biological_process
GO:0071333	cellular response to gluc ose stimulus	ISS	biological_process
GO:0071363	cellular response to grow th factor stimulus	IEA	biological_process
GO:0072661	protein targeting to plas ma membrane	IDA	biological_process
GO:0085029	extracellular matrix asse mbly	ISS	biological_process
GO:0097028	dendritic cell differenti ation	IEP	biological_process
GO:0097241	hematopoietic stem cell m igration to bone marrow	IDA	biological_process
GO:1900142	negative regulation of ol igodendrocyte apoptotic p rocess	IDA	biological_process
GO:1900165	negative regulation of in terleukin-6 secretion	IDA	biological_process
GO:2000270	negative regulation of fi broblast apoptotic proces s	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000510	positive regulation of de ndritic cell chemotaxis	IDA	biological_process
GO:2000533	negative regulation of re nal albumin absorption	ISS	biological_process
GO:2000669	negative regulation of de ndritic cell apoptotic pr ocess	IDA	biological_process
GO:0001764	neuron migration	IEA	biological_process
GO:0001786	phosphatidylserine bindin g	IDA	molecular_function
GO:0001934	positive regulation of pr otein phosphorylation	IEA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	ISS	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001961	positive regulation of cy tokine-mediated signaling pathway	IMP	biological_process
GO:0002576	platelet degranulation	TAS	biological_process
GO:0003104	positive regulation of gl omerular filtration	IEA	biological_process
GO:0003104	positive regulation of gl omerular filtration	ISS	biological_process
GO:0005102	receptor binding	IDA	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005245	voltage-gated calcium cha nnel activity	IDA	molecular_function
GO:0005509	calcium ion binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005788	endoplasmic reticulum lum en	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0006465	signal peptide processing	TAS	biological_process
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0006888	ER to Golgi vesicle-media ted transport	TAS	biological_process
GO:0006909	phagocytosis	IDA	biological_process
GO:0007050	cell cycle arrest	TAS	biological_process
GO:0007155	cell adhesion	TAS	biological_process
GO:0007165	signal transduction	IEA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0007167	enzyme linked receptor pr otein signaling pathway	IEA	biological_process
GO:0007596	blood coagulation	IEA	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0009267	cellular response to star vation	IEA	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010804	negative regulation of tu mor necrosis factor-media ted signaling pathway	IDA	biological_process
GO:0010934	macrophage cytokine produ ction	IEA	biological_process
GO:0016032	viral process	IEA	biological_process
GO:0016477	cell migration	TAS	biological_process
GO:0018105	peptidyl-serine phosphory lation	IDA	biological_process
GO:0018105	peptidyl-serine phosphory lation	IDA	biological_process
GO:0019064	fusion of virus membrane with host plasma membrane	IDA	biological_process
GO:0019079	viral genome replication	IDA	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0030296	protein tyrosine kinase a ctivator activity	IDA	molecular_function
GO:0030971	receptor tyrosine kinase binding	IPI	molecular_function
GO:0031093	platelet alpha granule lu men	TAS	cellular_component
GO:0031100	animal organ regeneration	IEA	biological_process
GO:0031589	cell-substrate adhesion	IEA	biological_process
GO:0032008	positive regulation of TO R signaling	IEA	biological_process
GO:0032008	positive regulation of TO R signaling	ISS	biological_process
GO:0032148	activation of protein kin ase B activity	IEA	biological_process
GO:0032148	activation of protein kin ase B activity	ISS	biological_process
GO:0032689	negative regulation of in terferon-gamma production	IDA	biological_process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032825	positive regulation of na tural killer cell differe ntiation	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033159	negative regulation of pr otein import into nucleus , translocation	IDA	biological_process
GO:0035457	cellular response to inte rferon-alpha	IDA	biological_process
GO:0035690	cellular response to drug	IEA	biological_process
GO:0035690	cellular response to drug	IDA	biological_process
GO:0035754	B cell chemotaxis	IDA	biological_process
GO:0040008	regulation of growth	IEA	biological_process
GO:0043027	cysteine-type endopeptida se inhibitor activity inv olved in apoptotic proces s	IDA	molecular_function
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043277	apoptotic cell clearance	IEA	biological_process
GO:0043277	apoptotic cell clearance	IDA	biological_process
GO:0043433	negative regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological_process
GO:0043491	protein kinase B signalin g	IEA	biological_process
GO:0043491	protein kinase B signalin g	IDA	biological_process
GO:0043491	protein kinase B signalin g	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0046718	viral entry into host cel l	IDA	biological_process
GO:0046813	receptor-mediated virion attachment to host cell	IDA	biological_process
GO:0046827	positive regulation of pr otein export from nucleus	IDA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0048018	receptor agonist activity	IEA	molecular_function
GO:0048018	receptor agonist activity	IDA	molecular_function
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0050711	negative regulation of in terleukin-1 secretion	IDA	biological_process
GO:0050766	positive regulation of ph agocytosis	IDA	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IEA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060090	binding, bridging	IDA	molecular_function
GO:0061098	positive regulation of pr otein tyrosine kinase act ivity	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070168	negative regulation of bi omineral tissue developme nt	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070527	platelet aggregation	TAS	biological_process
GO:0070588	calcium ion transmembrane transport	IDA	biological_process
GO:0071307	cellular response to vita min K	IDA	biological_process
GO:0071333	cellular response to gluc ose stimulus	IEA	biological_process
GO:0071333	cellular response to gluc ose stimulus	ISS	biological_process
GO:0071363	cellular response to grow th factor stimulus	IEA	biological_process
GO:0072661	protein targeting to plas ma membrane	IDA	biological_process
GO:0085029	extracellular matrix asse mbly	IEA	biological_process
GO:0085029	extracellular matrix asse mbly	ISS	biological_process
GO:0097028	dendritic cell differenti ation	IEP	biological_process
GO:0097241	hematopoietic stem cell m igration to bone marrow	IDA	biological_process
GO:1900142	negative regulation of ol igodendrocyte apoptotic p rocess	IDA	biological_process
GO:1900165	negative regulation of in terleukin-6 secretion	IDA	biological_process
GO:2000270	negative regulation of fi broblast apoptotic proces s	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000510	positive regulation of de ndritic cell chemotaxis	IDA	biological_process
GO:2000533	negative regulation of re nal albumin absorption	IEA	biological_process
GO:2000533	negative regulation of re nal albumin absorption	ISS	biological_process
GO:2000669	negative regulation of de ndritic cell apoptotic pr ocess	IDA	biological_process
GO:0001786	phosphatidylserine bindin g	IDA	molecular_function
GO:0001934	positive regulation of pr otein phosphorylation	ISS	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001961	positive regulation of cy tokine-mediated signaling pathway	IMP	biological_process
GO:0002576	platelet degranulation	TAS	biological_process
GO:0003104	positive regulation of gl omerular filtration	ISS	biological_process
GO:0005102	receptor binding	IDA	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005245	voltage-gated calcium cha nnel activity	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005788	endoplasmic reticulum lum en	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0006465	signal peptide processing	TAS	biological_process
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0006888	ER to Golgi vesicle-media ted transport	TAS	biological_process
GO:0006909	phagocytosis	IDA	biological_process
GO:0007050	cell cycle arrest	TAS	biological_process
GO:0007155	cell adhesion	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0007165	signal transduction	IDA	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010804	negative regulation of tu mor necrosis factor-media ted signaling pathway	IDA	biological_process
GO:0016477	cell migration	TAS	biological_process
GO:0018105	peptidyl-serine phosphory lation	IDA	biological_process
GO:0018105	peptidyl-serine phosphory lation	IDA	biological_process
GO:0019064	fusion of virus membrane with host plasma membrane	IDA	biological_process
GO:0019079	viral genome replication	IDA	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0030296	protein tyrosine kinase a ctivator activity	IDA	molecular_function
GO:0030971	receptor tyrosine kinase binding	IPI	molecular_function
GO:0031093	platelet alpha granule lu men	TAS	cellular_component
GO:0032008	positive regulation of TO R signaling	ISS	biological_process
GO:0032148	activation of protein kin ase B activity	ISS	biological_process
GO:0032689	negative regulation of in terferon-gamma production	IDA	biological_process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032825	positive regulation of na tural killer cell differe ntiation	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033159	negative regulation of pr otein import into nucleus , translocation	IDA	biological_process
GO:0035457	cellular response to inte rferon-alpha	IDA	biological_process
GO:0035690	cellular response to drug	IDA	biological_process
GO:0035754	B cell chemotaxis	IDA	biological_process
GO:0043027	cysteine-type endopeptida se inhibitor activity inv olved in apoptotic proces s	IDA	molecular_function
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043277	apoptotic cell clearance	IDA	biological_process
GO:0043433	negative regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological_process
GO:0043491	protein kinase B signalin g	IDA	biological_process
GO:0043491	protein kinase B signalin g	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0046718	viral entry into host cel l	IDA	biological_process
GO:0046813	receptor-mediated virion attachment to host cell	IDA	biological_process
GO:0046827	positive regulation of pr otein export from nucleus	IDA	biological_process
GO:0048018	receptor agonist activity	IDA	molecular_function
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0050711	negative regulation of in terleukin-1 secretion	IDA	biological_process
GO:0050766	positive regulation of ph agocytosis	IDA	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060090	binding, bridging	IDA	molecular_function
GO:0061098	positive regulation of pr otein tyrosine kinase act ivity	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070168	negative regulation of bi omineral tissue developme nt	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070527	platelet aggregation	TAS	biological_process
GO:0070588	calcium ion transmembrane transport	IDA	biological_process
GO:0071307	cellular response to vita min K	IDA	biological_process
GO:0071333	cellular response to gluc ose stimulus	ISS	biological_process
GO:0072661	protein targeting to plas ma membrane	IDA	biological_process
GO:0085029	extracellular matrix asse mbly	ISS	biological_process
GO:0097028	dendritic cell differenti ation	IEP	biological_process
GO:0097241	hematopoietic stem cell m igration to bone marrow	IDA	biological_process
GO:1900142	negative regulation of ol igodendrocyte apoptotic p rocess	IDA	biological_process
GO:1900165	negative regulation of in terleukin-6 secretion	IDA	biological_process
GO:2000270	negative regulation of fi broblast apoptotic proces s	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IDA	biological_process
GO:2000510	positive regulation of de ndritic cell chemotaxis	IDA	biological_process
GO:2000533	negative regulation of re nal albumin absorption	ISS	biological_process
GO:2000669	negative regulation of de ndritic cell apoptotic pr ocess	IDA	biological_process

KEGG pathways

hsa01521 EGFR tyrosine kinase inhibitor resistance

Diseases

Associated diseases	References
Ovarian endometriosis	PMID: 12029073
Male infertility	PMID: 24762434
Ovarian endometriosis	PMID: 12029073
Ovarian endometriosis	INFBASE12029073
Ovarian endometriosis	INFBASE12029073
Sticky platelet syndrome	PMID: 19696043
Stroke	PMID: 15108283

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
12029073	Ovarian en dometriosi s					Gas6 Axl Sky	Show abstract