Gene id
27178
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references
Gene Summary
Gene Symbol
IL37 Gene UCSC Ensembl
Aliases
FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
Gene name
interleukin 37
Alternate names
interleukin-37, FIL1 zeta, IL-1 zeta, IL-1F7b (IL-1H4, IL-1H, IL-1RP1), IL-1X protein, IL1F7 (canonical product IL-1F7b), interleukin 1 family member 7, interleukin 1, zeta, interleukin-1 homolog 4, interleukin-1 superfamily z, interleukin-1-related protein, interleukin-23,
Gene location
2q14.1 (112908884: 112918881) Exons: 7 NC_000002.12
Gene summary(Entrez)
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
OMIM
605510
Protein Summary
Protein general information
Q9NZH6 Name: Interleukin-37 (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-37)Length: 218 Mass: 24,126 Tissue specificity: In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are Sequence
MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMNFVHTSPKVKNLNPKKFSIHDQDHKVLVLDSG NLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAAQKESA RRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD Structural information
Other Databases
GeneCards: IL37;   Malacards: IL37
Gene ontology
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GO accession Term name Evidence code Go category
GO:0005125
cytokine activity
IBA
molecular_function
GO:0005149
interleukin-1 receptor bi nding
TAS
molecular_function
GO:0005149
interleukin-1 receptor bi nding
NAS
molecular_function
GO:0005576
extracellular region
NAS
cellular_component
GO:0005576
extracellular region
TAS
cellular_component
GO:0005576
extracellular region
TAS
cellular_component
GO:0005615
extracellular space
IBA
cellular_component
GO:0005634
nucleus
IDA
cellular_component
GO:0005730
nucleolus
IDA
cellular_component
GO:0005737
cytoplasm
IDA
cellular_component
GO:0005829
cytosol
IEA
cellular_component
GO:0006954
inflammatory response
IEA
biological_process
GO:0006955
immune response
NAS
biological_process
GO:0006955
immune response
NAS
biological_process
GO:0019221
cytokine-mediated signali ng pathway
IBA
biological_process
GO:0005125
cytokine activity
IBA
molecular_function
GO:0005125
cytokine activity
IEA
molecular_function
GO:0005149
interleukin-1 receptor bi nding
IEA
molecular_function
GO:0005149
interleukin-1 receptor bi nding
TAS
molecular_function
GO:0005149
interleukin-1 receptor bi nding
NAS
molecular_function
GO:0005576
extracellular region
IEA
cellular_component
GO:0005576
extracellular region
IEA
cellular_component
GO:0005576
extracellular region
NAS
cellular_component
GO:0005576
extracellular region
TAS
cellular_component
GO:0005576
extracellular region
TAS
cellular_component
GO:0005615
extracellular space
IEA
cellular_component
GO:0005615
extracellular space
IBA
cellular_component
GO:0005615
extracellular space
IEA
cellular_component
GO:0005634
nucleus
IEA
cellular_component
GO:0005634
nucleus
IEA
cellular_component
GO:0005634
nucleus
IDA
cellular_component
GO:0005730
nucleolus
IDA
cellular_component
GO:0005737
cytoplasm
IEA
cellular_component
GO:0005737
cytoplasm
IDA
cellular_component
GO:0005829
cytosol
IEA
cellular_component
GO:0006954
inflammatory response
IEA
biological_process
GO:0006955
immune response
IEA
biological_process
GO:0006955
immune response
NAS
biological_process
GO:0006955
immune response
NAS
biological_process
GO:0019221
cytokine-mediated signali ng pathway
IBA
biological_process
GO:0005125
cytokine activity
IBA
molecular_function
GO:0005149
interleukin-1 receptor bi nding
TAS
molecular_function
GO:0005149
interleukin-1 receptor bi nding
NAS
molecular_function
GO:0005576
extracellular region
NAS
cellular_component
GO:0005576
extracellular region
TAS
cellular_component
GO:0005576
extracellular region
TAS
cellular_component
GO:0005615
extracellular space
IBA
cellular_component
GO:0005634
nucleus
IDA
cellular_component
GO:0005730
nucleolus
IDA
cellular_component
GO:0005737
cytoplasm
IDA
cellular_component
GO:0006955
immune response
NAS
biological_process
GO:0006955
immune response
NAS
biological_process
GO:0019221
cytokine-mediated signali ng pathway
IBA
biological_process
Diseases
Associated diseases
References
Endometriosis INFBASE26342048
PubMed references
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