Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 28231
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol SLCO4A1   Gene   UCSC   Ensembl
Aliases OATP-E, OATP1, OATP4A1, OATPE, OATPRP1, POAT, SLC21A12
Gene name solute carrier organic anion transporter family member 4A1
Alternate names solute carrier organic anion transporter family member 4A1, OATP-RP1, colon organic anion transporter, organic anion transporter polypeptide-related protein 1, organic anion transporting polypeptide E, sodium-independent organic anion transporter E, solute carr,
Gene location 20q13.33 (62642444: 62690699)     Exons: 17     NC_000020.11
OMIM 612436

Protein Summary
Protein general information Q96BD0  

Name: Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide related protein 1) (OATP RP1) (OATPRP1) (POAT) (Organic anion transporting polypeptide E) (OATP E) (Sodium indepe

Length: 722  Mass: 77,193

Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes.

Sequence MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEV
RYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYD
IAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSR
YQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELT
TESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLS
IWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLR
GSAVIKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLM
YFSLCHAGCPAATETNVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALT
ATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLLYK
VLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV
Structural information
Protein Domains
 Kazal-like. (498-555)
Interpro:  IPR002350 IPR020846 IPR004156
Prosite:   PS51465 PS50850

Pfam:  		 PF07648 PF03137
CDD:   cd06174
STRING:   ENSP00000217159;
Other Databases GeneCards:  SLCO4A1;  Malacards:  SLCO4A1

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005886 plasma membrane
 TAS cellular_component
GO:0005887 integral component of pla
sma membrane
 IBA cellular_component
GO:0015347 sodium-independent organi
c anion transmembrane tra
nsporter activity
 IBA molecular_function
GO:0015349 thyroid hormone transmemb
rane transporter activity
 IBA molecular_function
GO:0015349 thyroid hormone transmemb
rane transporter activity
 TAS molecular_function
GO:0042403 thyroid hormone metabolic
process
 IEA biological_process
GO:0043252 sodium-independent organi
c anion transport
 IBA biological_process
GO:0043252 sodium-independent organi
c anion transport
 TAS biological_process
GO:0070327 thyroid hormone transport
 IBA biological_process
GO:0005215 transporter activity
 IEA molecular_function
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 TAS cellular_component
GO:0005887 integral component of pla
sma membrane
 IBA cellular_component
GO:0006810 transport
 IEA biological_process
GO:0006810 transport
 IEA biological_process
GO:0006811 ion transport
 IEA biological_process
GO:0015347 sodium-independent organi
c anion transmembrane tra
nsporter activity
 IBA molecular_function
GO:0015349 thyroid hormone transmemb
rane transporter activity
 IEA molecular_function
GO:0015349 thyroid hormone transmemb
rane transporter activity
 IBA molecular_function
GO:0015349 thyroid hormone transmemb
rane transporter activity
 TAS molecular_function
GO:0016020 membrane
 IEA cellular_component
GO:0016020 membrane
 IEA cellular_component
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0042403 thyroid hormone metabolic
process
 IEA biological_process
GO:0043252 sodium-independent organi
c anion transport
 IBA biological_process
GO:0043252 sodium-independent organi
c anion transport
 TAS biological_process
GO:0070327 thyroid hormone transport
 IEA biological_process
GO:0070327 thyroid hormone transport
 IBA biological_process
GO:0005886 plasma membrane
 TAS cellular_component
GO:0005887 integral component of pla
sma membrane
 IBA cellular_component
GO:0015347 sodium-independent organi
c anion transmembrane tra
nsporter activity
 IBA molecular_function
GO:0015349 thyroid hormone transmemb
rane transporter activity
 IBA molecular_function
GO:0015349 thyroid hormone transmemb
rane transporter activity
 TAS molecular_function
GO:0043252 sodium-independent organi
c anion transport
 IBA biological_process
GO:0043252 sodium-independent organi
c anion transport
 TAS biological_process
GO:0070327 thyroid hormone transport
 IBA biological_process

Diseases

Associated diseases References
Endometriosis (ovarian) PMID: 23656391
Amyotrophic lateral sclerosis (ALS) PMID: 17362836
Ovarian endometriosis INFBASE23656391
Ovarian endometriosis PMID: 23656391
Ovarian endometriosis PMID: 23656391
Polycystic ovary syndrome (PCOS) PMID: 26450365

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
23656391 Endometrio
sis (ovari
an)
11 women with e
ndometriosis an
d endometrial t
issue of the co
ntrols
 GATA5
SLCO4A1
 Show abstract