Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 283
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol ANG   Gene   UCSC   Ensembl
Aliases ALS9, HEL168, RAA1, RNASE4, RNASE5
Gene name angiogenin
Alternate names angiogenin, RNase 5, angiogenin, ribonuclease, RNase A family, 5, epididymis luminal protein 168, ribonuclease 5, ribonuclease A A1, ribonuclease A family member 5,
Gene location 14q11.2 (20684176: 20694185)     Exons: 3     NC_000014.9
Gene summary(Entrez) The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]
OMIM 105850

Protein Summary

Protein general information P03950  

Name: Angiogenin (EC 3.1.27. ) (Ribonuclease 5) (RNase 5)

Length: 147  Mass: 16,550

Tissue specificity: Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO

Sequence MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKR
SIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP
Structural information

Motifs
Nucleolar localization(55-59)
Interpro:  IPR001427 IPR023411 IPR023412
Prosite:   PS00127

Pfam:  
PF00074

PDB:  
1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V
PDBsum:   1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V
STRING:   ENSP00000336762;
Other Databases GeneCards:  ANG;  Malacards:  ANG

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001525 angiogenesis
TAS biological_process
GO:0001525 angiogenesis
IMP biological_process
GO:0001525 angiogenesis
IMP biological_process
GO:0001525 angiogenesis
IDA biological_process
GO:0001541 ovarian follicle developm
ent
NAS biological_process
GO:0001556 oocyte maturation
NAS biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001666 response to hypoxia
NAS biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001878 response to yeast
IDA biological_process
GO:0001890 placenta development
NAS biological_process
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0003677 DNA binding
IC molecular_function
GO:0003779 actin binding
IDA molecular_function
GO:0003779 actin binding
IDA molecular_function
GO:0004519 endonuclease activity
TAS molecular_function
GO:0004540 ribonuclease activity
IDA molecular_function
GO:0004540 ribonuclease activity
IDA molecular_function
GO:0005102 receptor binding
IDA molecular_function
GO:0005507 copper ion binding
IDA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005605 basal lamina
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005730 nucleolus
ISS cellular_component
GO:0006651 diacylglycerol biosynthet
ic process
IDA biological_process
GO:0007154 cell communication
NAS biological_process
GO:0007202 activation of phospholipa
se C activity
IMP biological_process
GO:0008201 heparin binding
IDA molecular_function
GO:0009303 rRNA transcription
IMP biological_process
GO:0009725 response to hormone
IDA biological_process
GO:0016477 cell migration
IMP biological_process
GO:0017148 negative regulation of tr
anslation
IEA biological_process
GO:0019731 antibacterial humoral res
ponse
IDA biological_process
GO:0019732 antifungal humoral respon
se
IDA biological_process
GO:0019843 rRNA binding
TAS molecular_function
GO:0030041 actin filament polymeriza
tion
ISS biological_process
GO:0030426 growth cone
ISS cellular_component
GO:0032148 activation of protein kin
ase B activity
IMP biological_process
GO:0032311 angiogenin-PRI complex
IDA cellular_component
GO:0032311 angiogenin-PRI complex
IPI cellular_component
GO:0032431 activation of phospholipa
se A2 activity
IMP biological_process
GO:0034332 adherens junction organiz
ation
TAS biological_process
GO:0042277 peptide binding
IDA molecular_function
GO:0042327 positive regulation of ph
osphorylation
IDA biological_process
GO:0042592 homeostatic process
NAS biological_process
GO:0042803 protein homodimerization
activity
IDA molecular_function
GO:0043025 neuronal cell body
ISS cellular_component
GO:0045087 innate immune response
IDA biological_process
GO:0048662 negative regulation of sm
ooth muscle cell prolifer
ation
IDA biological_process
GO:0050714 positive regulation of pr
otein secretion
ISS biological_process
GO:0050714 positive regulation of pr
otein secretion
IDA biological_process
GO:0050830 defense response to Gram-
positive bacterium
IDA biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0090501 RNA phosphodiester bond h
ydrolysis
IEA biological_process
GO:0001525 angiogenesis
IEA biological_process
GO:0001525 angiogenesis
TAS biological_process
GO:0001525 angiogenesis
IMP biological_process
GO:0001525 angiogenesis
IMP biological_process
GO:0001525 angiogenesis
IDA biological_process
GO:0001541 ovarian follicle developm
ent
NAS biological_process
GO:0001556 oocyte maturation
NAS biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001666 response to hypoxia
NAS biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001878 response to yeast
IEA biological_process
GO:0001878 response to yeast
IDA biological_process
GO:0001890 placenta development
NAS biological_process
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0003676 nucleic acid binding
IEA molecular_function
GO:0003677 DNA binding
IEA molecular_function
GO:0003677 DNA binding
IC molecular_function
GO:0003779 actin binding
IDA molecular_function
GO:0003779 actin binding
IDA molecular_function
GO:0004518 nuclease activity
IEA molecular_function
GO:0004519 endonuclease activity
IEA molecular_function
GO:0004519 endonuclease activity
TAS molecular_function
GO:0004540 ribonuclease activity
IEA molecular_function
GO:0004540 ribonuclease activity
IDA molecular_function
GO:0004540 ribonuclease activity
IDA molecular_function
GO:0005102 receptor binding
IDA molecular_function
GO:0005507 copper ion binding
IDA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005605 basal lamina
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005634 nucleus
IEA cellular_component
GO:0005634 nucleus
IEA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005730 nucleolus
ISS cellular_component
GO:0005730 nucleolus
IEA cellular_component
GO:0006651 diacylglycerol biosynthet
ic process
IDA biological_process
GO:0007154 cell communication
NAS biological_process
GO:0007202 activation of phospholipa
se C activity
IMP biological_process
GO:0007275 multicellular organism de
velopment
IEA biological_process
GO:0008201 heparin binding
IDA molecular_function
GO:0009303 rRNA transcription
IMP biological_process
GO:0009725 response to hormone
IDA biological_process
GO:0016477 cell migration
IMP biological_process
GO:0016787 hydrolase activity
IEA molecular_function
GO:0017148 negative regulation of tr
anslation
IEA biological_process
GO:0019731 antibacterial humoral res
ponse
IEA biological_process
GO:0019731 antibacterial humoral res
ponse
IDA biological_process
GO:0019732 antifungal humoral respon
se
IEA biological_process
GO:0019732 antifungal humoral respon
se
IDA biological_process
GO:0019843 rRNA binding
TAS molecular_function
GO:0030041 actin filament polymeriza
tion
ISS biological_process
GO:0030154 cell differentiation
IEA biological_process
GO:0030426 growth cone
IEA cellular_component
GO:0030426 growth cone
ISS cellular_component
GO:0031410 cytoplasmic vesicle
IEA cellular_component
GO:0032148 activation of protein kin
ase B activity
IMP biological_process
GO:0032311 angiogenin-PRI complex
IDA cellular_component
GO:0032311 angiogenin-PRI complex
IPI cellular_component
GO:0032431 activation of phospholipa
se A2 activity
IMP biological_process
GO:0034332 adherens junction organiz
ation
TAS biological_process
GO:0042277 peptide binding
IDA molecular_function
GO:0042327 positive regulation of ph
osphorylation
IDA biological_process
GO:0042592 homeostatic process
NAS biological_process
GO:0042803 protein homodimerization
activity
IDA molecular_function
GO:0043025 neuronal cell body
IEA cellular_component
GO:0043025 neuronal cell body
ISS cellular_component
GO:0045087 innate immune response
IEA biological_process
GO:0045087 innate immune response
IDA biological_process
GO:0048662 negative regulation of sm
ooth muscle cell prolifer
ation
IDA biological_process
GO:0050714 positive regulation of pr
otein secretion
ISS biological_process
GO:0050714 positive regulation of pr
otein secretion
IDA biological_process
GO:0050830 defense response to Gram-
positive bacterium
IEA biological_process
GO:0050830 defense response to Gram-
positive bacterium
IDA biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0090305 nucleic acid phosphodiest
er bond hydrolysis
IEA biological_process
GO:0090501 RNA phosphodiester bond h
ydrolysis
IEA biological_process
GO:0001525 angiogenesis
TAS biological_process
GO:0001525 angiogenesis
IMP biological_process
GO:0001525 angiogenesis
IMP biological_process
GO:0001525 angiogenesis
IDA biological_process
GO:0001541 ovarian follicle developm
ent
NAS biological_process
GO:0001556 oocyte maturation
NAS biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001666 response to hypoxia
NAS biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001666 response to hypoxia
IDA biological_process
GO:0001878 response to yeast
IDA biological_process
GO:0001890 placenta development
NAS biological_process
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0003677 DNA binding
IC molecular_function
GO:0003779 actin binding
IDA molecular_function
GO:0003779 actin binding
IDA molecular_function
GO:0004519 endonuclease activity
TAS molecular_function
GO:0004540 ribonuclease activity
IDA molecular_function
GO:0004540 ribonuclease activity
IDA molecular_function
GO:0005102 receptor binding
IDA molecular_function
GO:0005507 copper ion binding
IDA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005605 basal lamina
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
IDA cellular_component
GO:0005730 nucleolus
ISS cellular_component
GO:0006651 diacylglycerol biosynthet
ic process
IDA biological_process
GO:0007154 cell communication
NAS biological_process
GO:0007202 activation of phospholipa
se C activity
IMP biological_process
GO:0008201 heparin binding
IDA molecular_function
GO:0009303 rRNA transcription
IMP biological_process
GO:0009725 response to hormone
IDA biological_process
GO:0016477 cell migration
IMP biological_process
GO:0019731 antibacterial humoral res
ponse
IDA biological_process
GO:0019732 antifungal humoral respon
se
IDA biological_process
GO:0019843 rRNA binding
TAS molecular_function
GO:0030041 actin filament polymeriza
tion
ISS biological_process
GO:0030426 growth cone
ISS cellular_component
GO:0032148 activation of protein kin
ase B activity
IMP biological_process
GO:0032311 angiogenin-PRI complex
IDA cellular_component
GO:0032311 angiogenin-PRI complex
IPI cellular_component
GO:0032431 activation of phospholipa
se A2 activity
IMP biological_process
GO:0034332 adherens junction organiz
ation
TAS biological_process
GO:0042277 peptide binding
IDA molecular_function
GO:0042327 positive regulation of ph
osphorylation
IDA biological_process
GO:0042592 homeostatic process
NAS biological_process
GO:0042803 protein homodimerization
activity
IDA molecular_function
GO:0043025 neuronal cell body
ISS cellular_component
GO:0045087 innate immune response
IDA biological_process
GO:0048662 negative regulation of sm
ooth muscle cell prolifer
ation
IDA biological_process
GO:0050714 positive regulation of pr
otein secretion
ISS biological_process
GO:0050714 positive regulation of pr
otein secretion
IDA biological_process
GO:0050830 defense response to Gram-
positive bacterium
IDA biological_process
GO:0070062 extracellular exosome
IDA cellular_component

Diseases

Associated diseases References
Amyotrophic lateral sclerosis (ALS) PMID: 17113198
Endometriosis PMID: 25920308
Hypertension PMID: 19253715
Hypertrophy PMID: 19253715
Implantation failure PMID: 18955785
Oocyte maturity and fertilization PMID: 11438326
Implantation defects INFBASE18955785
Endometriosis INFBASE18955785

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
15236995 Endometrio
sis

64 (38 women wi
th endometriosi
s, 26 women wit
h cystadenomas)
Angiogenin
Show abstract
14748845 Endometrio
sis

148 (77 cases,
71 controls)
TNFR-1
angiogenin
Show abstract
18955785 Endometrio
sis

61 (32 women wi
th endometriosi
s and 29 contro
l women)

Show abstract