Endometriosis Knowledgebase

Search Result

Gene id

2950

Gene Summary SNPs Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

GSTP1 Gene UCSC Ensembl

Aliases

DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI

Gene name

glutathione S-transferase pi 1

Alternate names

glutathione S-transferase P, GST class-pi, GSTP1-1, deafness, X-linked 7, epididymis secretory protein Li 22, fatty acid ethyl ester synthase III,

Gene location

11q13.2 (67583594: 67586652) Exons: 7 NC_000011.10

Gene summary(Entrez)

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

OMIM

134660

SNPs

rs1695

Strand:    Allele origin:   Allele change: A/G   Mutation type: snp

CM000673.2   g.67585218A>G
NC_000011.10   g.67585218A>G
NC_000011.9   g.67352689A>G
NG_012075.1   g.6624A>G
NM_000852.3   c.313A>G
NP_000843.1   p.Ile105Val
XP_005274015.1   p.Ile105Val
Clinical Significance: drug-response

Protein Summary

Protein general information

P09211

Name: Glutathione S transferase P (EC 2.5.1.18) (GST class pi) (GSTP1 1)

Length: 210 Mass: 23,356

Sequence

MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGR
TLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQIS
FADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ

Structural information

Protein Domains	GST (2-81) GST (83-204)
Interpro:	IPR010987 IPR004045 IPR004046 IPR003082 IPR012336
Prosite:	PS50405 PS50404
Pfam:	PF14497 PF02798
PDB:	10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5DAK 5DAL 5DCG
PDBsum:	10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5DAK 5DAL 5DCG
MINT:	4998983
STRING:	ENSP00000381607;

Other Databases

GeneCards: GSTP1; Malacards: GSTP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000302	response to reactive oxyg en species	ISS	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0002674	negative regulation of ac ute inflammatory response	NAS	biological_process
GO:0004364	glutathione transferase a ctivity	IDA	molecular_function
GO:0004364	glutathione transferase a ctivity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005622	intracellular	IDA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005739	mitochondrion	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0006469	negative regulation of pr otein kinase activity	IDA	biological_process
GO:0006749	glutathione metabolic pro cess	IDA	biological_process
GO:0006805	xenobiotic metabolic proc ess	IDA	biological_process
GO:0007417	central nervous system de velopment	TAS	biological_process
GO:0008144	drug binding	IEA	molecular_function
GO:0008432	JUN kinase binding	ISS	molecular_function
GO:0009636	response to toxic substan ce	IEA	biological_process
GO:0009890	negative regulation of bi osynthetic process	IDA	biological_process
GO:0010804	negative regulation of tu mor necrosis factor-media ted signaling pathway	IC	biological_process
GO:0014003	oligodendrocyte developme nt	IEA	biological_process
GO:0019207	kinase regulator activity	ISS	molecular_function
GO:0031100	animal organ regeneration	IEA	biological_process
GO:0031982	vesicle	IDA	cellular_component
GO:0032355	response to estradiol	IEA	biological_process
GO:0032691	negative regulation of in terleukin-1 beta producti on	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032869	cellular response to insu lin stimulus	IEA	biological_process
GO:0032872	regulation of stress-acti vated MAPK cascade	ISS	biological_process
GO:0032873	negative regulation of st ress-activated MAPK casca de	ISS	biological_process
GO:0032930	positive regulation of su peroxide anion generation	ISS	biological_process
GO:0033591	response to L-ascorbic ac id	IEA	biological_process
GO:0035726	common myeloid progenitor cell proliferation	ISS	biological_process
GO:0035730	S-nitrosoglutathione bind ing	IDA	molecular_function
GO:0035731	dinitrosyl-iron complex b inding	IDA	molecular_function
GO:0035731	dinitrosyl-iron complex b inding	IDA	molecular_function
GO:0035732	nitric oxide storage	NAS	biological_process
GO:0043066	negative regulation of ap optotic process	TAS	biological_process
GO:0043124	negative regulation of I- kappaB kinase/NF-kappaB s ignaling	ISS	biological_process
GO:0043200	response to amino acid	IEA	biological_process
GO:0043295	glutathione binding	IEA	molecular_function
GO:0043407	negative regulation of MA P kinase activity	IDA	biological_process
GO:0043409	negative regulation of MA PK cascade	NAS	biological_process
GO:0043508	negative regulation of JU N kinase activity	IDA	biological_process
GO:0045471	response to ethanol	IEA	biological_process
GO:0046689	response to mercury ion	IEA	biological_process
GO:0048147	negative regulation of fi broblast proliferation	ISS	biological_process
GO:0051771	negative regulation of ni tric-oxide synthase biosy nthetic process	IDA	biological_process
GO:0070026	nitric oxide binding	NAS	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070372	regulation of ERK1 and ER K2 cascade	ISS	biological_process
GO:0070373	negative regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070664	negative regulation of le ukocyte proliferation	ISS	biological_process
GO:0071222	cellular response to lipo polysaccharide	ISS	biological_process
GO:0071364	cellular response to epid ermal growth factor stimu lus	IEA	biological_process
GO:0071385	cellular response to gluc ocorticoid stimulus	IEA	biological_process
GO:0071460	cellular response to cell -matrix adhesion	IEA	biological_process
GO:0071638	negative regulation of mo nocyte chemotactic protei n-1 production	IDA	biological_process
GO:0097057	TRAF2-GSTP1 complex	IDA	cellular_component
GO:1901687	glutathione derivative bi osynthetic process	TAS	biological_process
GO:2001237	negative regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:0000302	response to reactive oxyg en species	ISS	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0002674	negative regulation of ac ute inflammatory response	NAS	biological_process
GO:0004364	glutathione transferase a ctivity	IEA	molecular_function
GO:0004364	glutathione transferase a ctivity	IEA	molecular_function
GO:0004364	glutathione transferase a ctivity	IEA	molecular_function
GO:0004364	glutathione transferase a ctivity	IDA	molecular_function
GO:0004364	glutathione transferase a ctivity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005622	intracellular	IDA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005739	mitochondrion	IDA	cellular_component
GO:0005829	cytosol	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0006469	negative regulation of pr otein kinase activity	IDA	biological_process
GO:0006749	glutathione metabolic pro cess	IDA	biological_process
GO:0006805	xenobiotic metabolic proc ess	IEA	biological_process
GO:0006805	xenobiotic metabolic proc ess	IDA	biological_process
GO:0007417	central nervous system de velopment	TAS	biological_process
GO:0008144	drug binding	IEA	molecular_function
GO:0008152	metabolic process	IEA	biological_process
GO:0008432	JUN kinase binding	ISS	molecular_function
GO:0009636	response to toxic substan ce	IEA	biological_process
GO:0009890	negative regulation of bi osynthetic process	IDA	biological_process
GO:0010804	negative regulation of tu mor necrosis factor-media ted signaling pathway	IC	biological_process
GO:0014003	oligodendrocyte developme nt	IEA	biological_process
GO:0016740	transferase activity	IEA	molecular_function
GO:0019207	kinase regulator activity	ISS	molecular_function
GO:0031100	animal organ regeneration	IEA	biological_process
GO:0031667	response to nutrient leve ls	IEA	biological_process
GO:0031982	vesicle	IDA	cellular_component
GO:0032355	response to estradiol	IEA	biological_process
GO:0032691	negative regulation of in terleukin-1 beta producti on	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032869	cellular response to insu lin stimulus	IEA	biological_process
GO:0032872	regulation of stress-acti vated MAPK cascade	ISS	biological_process
GO:0032873	negative regulation of st ress-activated MAPK casca de	ISS	biological_process
GO:0032930	positive regulation of su peroxide anion generation	ISS	biological_process
GO:0033591	response to L-ascorbic ac id	IEA	biological_process
GO:0035726	common myeloid progenitor cell proliferation	ISS	biological_process
GO:0035730	S-nitrosoglutathione bind ing	IDA	molecular_function
GO:0035731	dinitrosyl-iron complex b inding	IDA	molecular_function
GO:0035731	dinitrosyl-iron complex b inding	IDA	molecular_function
GO:0035732	nitric oxide storage	NAS	biological_process
GO:0043066	negative regulation of ap optotic process	TAS	biological_process
GO:0043124	negative regulation of I- kappaB kinase/NF-kappaB s ignaling	ISS	biological_process
GO:0043200	response to amino acid	IEA	biological_process
GO:0043295	glutathione binding	IEA	molecular_function
GO:0043407	negative regulation of MA P kinase activity	IDA	biological_process
GO:0043409	negative regulation of MA PK cascade	NAS	biological_process
GO:0043508	negative regulation of JU N kinase activity	IDA	biological_process
GO:0045471	response to ethanol	IEA	biological_process
GO:0046689	response to mercury ion	IEA	biological_process
GO:0048147	negative regulation of fi broblast proliferation	ISS	biological_process
GO:0051771	negative regulation of ni tric-oxide synthase biosy nthetic process	IDA	biological_process
GO:0070026	nitric oxide binding	NAS	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070372	regulation of ERK1 and ER K2 cascade	ISS	biological_process
GO:0070373	negative regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070664	negative regulation of le ukocyte proliferation	ISS	biological_process
GO:0071222	cellular response to lipo polysaccharide	ISS	biological_process
GO:0071364	cellular response to epid ermal growth factor stimu lus	IEA	biological_process
GO:0071385	cellular response to gluc ocorticoid stimulus	IEA	biological_process
GO:0071460	cellular response to cell -matrix adhesion	IEA	biological_process
GO:0071638	negative regulation of mo nocyte chemotactic protei n-1 production	IDA	biological_process
GO:0097057	TRAF2-GSTP1 complex	IDA	cellular_component
GO:1901687	glutathione derivative bi osynthetic process	TAS	biological_process
GO:2001237	negative regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:0000302	response to reactive oxyg en species	ISS	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0002674	negative regulation of ac ute inflammatory response	NAS	biological_process
GO:0004364	glutathione transferase a ctivity	IDA	molecular_function
GO:0004364	glutathione transferase a ctivity	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005622	intracellular	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005739	mitochondrion	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006469	negative regulation of pr otein kinase activity	IDA	biological_process
GO:0006749	glutathione metabolic pro cess	IDA	biological_process
GO:0006805	xenobiotic metabolic proc ess	IDA	biological_process
GO:0007417	central nervous system de velopment	TAS	biological_process
GO:0008432	JUN kinase binding	ISS	molecular_function
GO:0009890	negative regulation of bi osynthetic process	IDA	biological_process
GO:0010804	negative regulation of tu mor necrosis factor-media ted signaling pathway	IC	biological_process
GO:0019207	kinase regulator activity	ISS	molecular_function
GO:0031982	vesicle	IDA	cellular_component
GO:0032691	negative regulation of in terleukin-1 beta producti on	IDA	biological_process
GO:0032720	negative regulation of tu mor necrosis factor produ ction	IDA	biological_process
GO:0032872	regulation of stress-acti vated MAPK cascade	ISS	biological_process
GO:0032873	negative regulation of st ress-activated MAPK casca de	ISS	biological_process
GO:0032930	positive regulation of su peroxide anion generation	ISS	biological_process
GO:0035726	common myeloid progenitor cell proliferation	ISS	biological_process
GO:0035730	S-nitrosoglutathione bind ing	IDA	molecular_function
GO:0035731	dinitrosyl-iron complex b inding	IDA	molecular_function
GO:0035731	dinitrosyl-iron complex b inding	IDA	molecular_function
GO:0035732	nitric oxide storage	NAS	biological_process
GO:0043066	negative regulation of ap optotic process	TAS	biological_process
GO:0043124	negative regulation of I- kappaB kinase/NF-kappaB s ignaling	ISS	biological_process
GO:0043407	negative regulation of MA P kinase activity	IDA	biological_process
GO:0043409	negative regulation of MA PK cascade	NAS	biological_process
GO:0043508	negative regulation of JU N kinase activity	IDA	biological_process
GO:0048147	negative regulation of fi broblast proliferation	ISS	biological_process
GO:0051771	negative regulation of ni tric-oxide synthase biosy nthetic process	IDA	biological_process
GO:0070026	nitric oxide binding	NAS	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070372	regulation of ERK1 and ER K2 cascade	ISS	biological_process
GO:0070373	negative regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070664	negative regulation of le ukocyte proliferation	ISS	biological_process
GO:0071222	cellular response to lipo polysaccharide	ISS	biological_process
GO:0071638	negative regulation of mo nocyte chemotactic protei n-1 production	IDA	biological_process
GO:0097057	TRAF2-GSTP1 complex	IDA	cellular_component
GO:1901687	glutathione derivative bi osynthetic process	TAS	biological_process
GO:2001237	negative regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process

KEGG pathways

hsa05200  Pathways in cancer
hsa05418  Fluid shear stress and atherosclerosis
hsa05215  Prostate cancer
hsa01524  Platinum drug resistance
hsa05204  Chemical carcinogenesis
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00480  Glutathione metabolism

Diseases

Associated diseases	References
Alzheimer's disease	PMID: 19141999
Aplastic anemia	PMID: 16079101
Asthma	PMID: 11927838
Atopy	PMID: 10806136
Bronchopulmonary dysplasia	PMID: 14726935
Chronic obstructive pulmonary disease (COPD)	PMID: 12149538
Chronic obstructive pulmonary disease (COPD)	PMID: 15161530
Cleft lip	PMID: 18449058
Connective tissue diseases	PMID: 19527514
Crohn's disease	PMID: 12631667
Cystic fibrosis	PMID: 15125256
Dermatitis	PMID: 19842992
Dyskinesias	PMID: 20041472
Encephalopathy	PMID: 17022435
Endometriosis	PMID: 24183097
Eye diseases	PMID: 18447907
Fatty liver	PMID: 18492019
Gastric disease	PMID: 15734972
Genital diseases	PMID: 19799358
Glaucoma	PMID: 11040079
Graves disease	PMID: 19903800
Hepatic veno-occlusive disease	PMID: 18641537
Hypertension	PMID: 16369102
Idiopathic azoospermia	PMID: 25532576
Keratosis	PMID: 12485442
Male infertility	PMID: 22903474
Miscarriage	PMID: 19892789
Nephrotic Syndrome	PMID: 18594869
Neutropenia	PMID: 19074750
Non-allergic nasal polyposis	PMID: 19701760
Obesity	PMID: 19057702
Oligoasthenoteratozoospermia	PMID: 23324581
Osteoarthritis	PMID: 12421093
Pancreatitis	PMID: 15131792
Parkinson's disease	PMID: 15288444
Peripheral nervous system diseases	PMID: 19223573
Preeclampsia	PMID: 18712057
Endometriosis	INFBASE23141164
Prostate cancer	KEGG: H00024
Schizophrenia	PMID: 12691788
Sensation Disorders	PMID: 18776599
Varicocele	PMID: 21546615

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
23141164	Endometrio sis	GG + AG [from AhR -1661G/A (GG) and GSTP1 -313A/G (AG)]	Han Chi nese	925 (432 endome triosis patient s, 493 patients with fallopian tube ligation, tubal recanali zation, laparos copic hydrotuba tion, benign ov arian tumor and teratoma surge ries without en dometriosis as control group )		AhR GSTP1	Show abstract
15878920	Endometrio sis			300 (150 patien ts with endomet riosis, 150 con trols)		GSTP1 GSTT1	Show abstract