Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 2952
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol GSTT1   Gene   UCSC   Ensembl
Gene name glutathione S-transferase theta 1
Alternate names glutathione S-transferase theta-1, GST class-theta-1, glutathione transferase T1-1,
Gene location 22q11.23 (: )     Exons:     
Gene summary(Entrez) The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
OMIM 600436

Protein Summary

Protein general information P30711  

Name: Glutathione S transferase theta 1 (EC 2.5.1.18) (GST class theta 1) (Glutathione transferase T1 1)

Length: 240  Mass: 27,335

Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles. {ECO

Sequence MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDGDFTLTESVAILLYLT
RKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMFPVFLGEPVSPQTLAATLAELDVTLQLLEDK
FLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADP
TIKQKLMPWVLAMIR
Structural information
Protein Domains
GST (2-82)
GST (88-220)
Interpro:  IPR010987 IPR004045 IPR004046 IPR012336
Prosite:   PS50405 PS50404

Pfam:  
PF00043 PF13417

PDB:  
2C3N 2C3Q 2C3T
PDBsum:   2C3N 2C3Q 2C3T
STRING:   ENSP00000248935;
Other Databases GeneCards:  GSTT1;  Malacards:  GSTT1

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
TAS molecular_function
GO:0004602 glutathione peroxidase ac
tivity
IDA molecular_function
GO:0004602 glutathione peroxidase ac
tivity
IDA molecular_function
GO:0005829 cytosol
IDA cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:0098869 cellular oxidant detoxifi
cation
IEA biological_process
GO:1901687 glutathione derivative bi
osynthetic process
TAS biological_process
GO:0004364 glutathione transferase a
ctivity
IEA molecular_function
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
TAS molecular_function
GO:0004602 glutathione peroxidase ac
tivity
IDA molecular_function
GO:0004602 glutathione peroxidase ac
tivity
IDA molecular_function
GO:0005737 cytoplasm
IEA cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0005829 cytosol
IDA cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0016740 transferase activity
IEA molecular_function
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:0098869 cellular oxidant detoxifi
cation
IEA biological_process
GO:1901687 glutathione derivative bi
osynthetic process
TAS biological_process
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
IDA molecular_function
GO:0004364 glutathione transferase a
ctivity
TAS molecular_function
GO:0004602 glutathione peroxidase ac
tivity
IDA molecular_function
GO:0004602 glutathione peroxidase ac
tivity
IDA molecular_function
GO:0005829 cytosol
IDA cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0006749 glutathione metabolic pro
cess
IDA biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070062 extracellular exosome
IDA cellular_component
GO:1901687 glutathione derivative bi
osynthetic process
TAS biological_process

KEGG pathways

hsa05418  Fluid shear stress and atherosclerosis
hsa01524  Platinum drug resistance
hsa05204  Chemical carcinogenesis
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00480  Glutathione metabolism

Diseases

Associated diseases References
Aplastic anemia PMID: 16079101
Asthma PMID: 12018173
Atherosclerosis PMID: 12579334
Azoospermia PMID: 23450492
Cancer PMID: 20056567
Chronic obstructive pulmonary disease (COPD) PMID: 12149538
Chronic toxic encephalopathy PMID: 14992466
Cleft lip PMID: 18698632
Crohn's disease PMID: 12631667
Cystic fibrosis PMID: 15115915
Diabetes PMID: 12732844
Diabetic neuropathy PMID: 15125229
Ehlers-Danlos syndrome PMID: 17020091
Encephalopathy PMID: 17022435
Endometriosis PMID: 22547312
Eye diseases PMID: 18447907
Fatty liver PMID: 18492019
Fetal growth retardation PMID: 19440446
Gastric disease PMID: 15734972
Genital diseases PMID: 19799358
Glaucoma PMID: 11040079
Hepatic veno-occlusive disease PMID: 18641537
Impaired spermatogenesis PMID: 23311983
Keratosis PMID: 12485442
Limb deficiency defects PMID: 16906563
Male infertility PMID: 18774560
Miscarriage PMID: 19892789
Myelodysplastic syndrome PMID: 16620556
Nephrotic syndrome PMID: 18594869
Neuropathy PMID: 15838728
Neutropenia PMID: 19074750
Non-allergic nasal polyposis PMID: 19701760
Obesity PMID: 19057702
Oligozoospermia PMID: 25532576
Oocyte quality PMID: 17919612
Optic nerve diseases PMID: 19286687
Osteoarthritis PMID: 12421093
Pancreatitis PMID: 15131792
Parkinson's disease PMID: 15279067
Peripheral nervous system diseases PMID: 19223573
Polycystic ovaries (PCO) PMID: 15333250
Preeclampsia PMID: 15734083
Premature birth PMID: 19527514
Premature ovarian failure ( POF) PMID: 18630123
Preterm delivery PMID: 18589596
Proteinuria PMID: 18455004
Psoriasis PMID: 12713578
Schizophrenia PMID: 18449862
Tardive dyskinesia PMID: 16160620
Varicocele PMID: 21546615

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
26350109 Endometrio
sis
Brazili
an
218 (121 confir
med endometrios
is, 97 women wi
thout evidence
of endometriosi
s)
Female infertility
Show abstract
12760253 Endometrio
sis

74 patients wit
h extragenital
endometriosis
CYP1A1
mEPHX1
CYP2E1
NAT2
and GSTM1
Show abstract
11730751 Endometrio
sis
CYP1A1 m1 polymorphism, GSTM1 null deletion, GSTT1 null deletion

GSTT1
CYP1A1
GSTM1
Show abstract
25549292 Endometrio
sis
Tunisia
n
255 (105 women
with endometrio
sis, 150 health
y women with no
laparoscopic e
vidence of dise
ase)
GSTM1
GSTT1
Show abstract
25461363 Endometrio
sis
Caucasi
ans, As
ians
GSTM1 (2593 cas
es, 2732 contro
ls), GSTT1 (252
0 cases and 250
8 controls)
GSTM1
GSTT1
Show abstract
25208225 Endometrio
sis
Chinese

GSTM1
GSTT1
Show abstract
23979901 Endometrio
sis

96 (50 women di
agnosed with en
dometriosis, 46
women without
endometriosis)
GSTM1
GSTT1
Show abstract
26370772 Endometrio
sis
Chinese
Han
917 (404 cases,
513 controls)

Show abstract
17513317 Endometrio
sis
AhRR codon 185, GSTT1 polymorphisms
572 (316 women
with advanced s
tage endometrio
sis, 256 contro
l women without
endometriosis)
GSTT1
AhRR
Show abstract
16291859 Endometrio
sis

GSTM1 (3344 (15
39 cases, 1805
controls)), GST
T1 (1580 (746 c
ases, 834 contr
ols))
GSTT1
Show abstract
15059587 Endometrio
sis
Uygurs,
Hans
333 (Uygurs (10
7 controls and
41 cases) and t
he Hans (105 co
ntrols and 80 c
ases))
GSTT1
GSTM1
Show abstract
12875700 Endometrio
sis
Han Chi
nese
96 (68 women w
ith endometrios
is, 28 without
endometriosis)
GSTM1
GSTT1
Show abstract
10381818 Endometrio
sis
NAT2*5 allele French
137 (36 minimal
/mild endometri
osis, 29 modera
te/severe endom
etriosis, 72 co
ntrols)
GSTT1
NAT2
GSTM1
Show abstract
10764452 Endometrio
sis
CYP1A1, CYP1A2, CYP1B1
43 (33 eutopic
endometrial tis
sue, 10 endomet
riotic tissue s
amples)
Female infertility CYP1A1
CYP1A2
CYP1B1
Show abstract
17513317 Endometrio
sis

572 (316 women
with advanced s
tage endometrio
sis, 256 contro
l women without
endometriosis)
AhRR
GSTT1
Show abstract