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Gene id

3123

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

HLA-DRB1 Gene UCSC Ensembl

Aliases

DRB1, HLA-DR1B, HLA-DRB, SS1

Gene name

major histocompatibility complex, class II, DR beta 1

Alternate names

major histocompatibility complex, class II, DR beta 1, HLA class II histocompatibility antigen, DR-1 beta chain, MHC class II HLA-DR beta 1 chain, human leucocyte antigen DRB1, lymphocyte antigen DRB1,

Gene location

6p21.32 (32589835: 32578768) Exons: 6 NC_000006.12

Gene summary(Entrez)

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

OMIM

142857

Protein Summary

Protein general information

P01911

Name: HLA class II histocompatibility antigen, DRB1 15 beta chain (DW2.2/DR2.2) (MHC class II antigen DRB1*15)

Length: 266 Mass: 29,966

Sequence

MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGE
FRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSG
FYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQ
SKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS

Structural information

Protein Domains	Ig-like (126-214)
Interpro:	IPR007110 IPR013783 IPR003006 IPR003597 IPR011162 IPR014745 IPR000353
Prosite:	PS50835 PS00290
Pfam:	PF07654 PF00969
PDB:	1BX2 1YMM 2WBJ
PDBsum:	1BX2 1YMM 2WBJ
STRING:	ENSP00000353099;

Other Databases

GeneCards: HLA-DRB1; Malacards: HLA-DRB1

Protein general information

P01912

Name: HLA class II histocompatibility antigen, DRB1 3 chain (Clone P2 beta 3) (MHC class II antigen DRB1*3)

Length: 266 Mass: 30,120

Sequence

MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYSTSECHFFNGTERVRYLDRYFHNQEENVRFDSDVGE
FRAVTELGRPDAEYWNSQKDLLEQKRGRVDNYCRHNYGVVESFTVQRRVHPKVTVYPSKTQPLQHHNLLVCSVSG
FYPGSIEVRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQ
SKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPRGFLS

Structural information

Protein Domains	Ig-like (126-214)
Interpro:	IPR007110 IPR013783 IPR003006 IPR003597 IPR011162 IPR014745 IPR000353
Prosite:	PS50835 PS00290
Pfam:	PF07654 PF00969
PDB:	1A6A
PDBsum:	1A6A
DIP:	6064
MINT:	1505391

Other Databases

GeneCards: HLA-DRB1; Malacards: HLA-DRB1

Protein general information

Q29974

Name: HLA class II histocompatibility antigen, DRB1 16 beta chain (MHC class II antigen DRB1*16) (DR 16) (DR16)

Length: 266 Mass: 30,030

Sequence

MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGE
YRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSG
FYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQ
SKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS

Structural information

Protein Domains	Ig-like (126-214)
Interpro:	IPR007110 IPR013783 IPR003006 IPR003597 IPR011162 IPR014745 IPR000353
Prosite:	PS50835 PS00290
Pfam:	PF07654 PF00969
STRING:	ENSP00000353099;

Other Databases

GeneCards: HLA-DRB1; Malacards: HLA-DRB1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological_process
GO:0002437	inflammatory response to antigenic stimulus	IDA	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006955	immune response	TAS	biological_process
GO:0006955	immune response	IDA	biological_process
GO:0006955	immune response	IDA	biological_process
GO:0006955	immune response	IMP	biological_process
GO:0009897	external side of plasma m embrane	IDA	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	TAS	cellular_component
GO:0016045	detection of bacterium	IMP	biological_process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032395	MHC class II receptor act ivity	TAS	molecular_function
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032673	regulation of interleukin -4 production	IDA	biological_process
GO:0032689	negative regulation of in terferon-gamma production	IMP	biological_process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	IMP	biological_process
GO:0042088	T-helper 1 type immune re sponse	IMP	biological_process
GO:0042130	negative regulation of T cell proliferation	IMP	biological_process
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051262	protein tetramerization	IDA	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:2001179	regulation of interleukin -10 secretion	IDA	biological_process
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002376	immune system process	IEA	biological_process
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological_process
GO:0002437	inflammatory response to antigenic stimulus	IDA	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological_process
GO:0002504	antigen processing and pr esentation of peptide or polysaccharide antigen vi a MHC class II	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005764	lysosome	IEA	cellular_component
GO:0005765	lysosomal membrane	IEA	cellular_component
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005768	endosome	IEA	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006955	immune response	IEA	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0006955	immune response	IDA	biological_process
GO:0006955	immune response	IDA	biological_process
GO:0006955	immune response	IMP	biological_process
GO:0009897	external side of plasma m embrane	IDA	cellular_component
GO:0010008	endosome membrane	IEA	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	TAS	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016045	detection of bacterium	IMP	biological_process
GO:0019882	antigen processing and pr esentation	IEA	biological_process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IEA	cellular_component
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032395	MHC class II receptor act ivity	TAS	molecular_function
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032673	regulation of interleukin -4 production	IDA	biological_process
GO:0032689	negative regulation of in terferon-gamma production	IMP	biological_process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	IMP	biological_process
GO:0042088	T-helper 1 type immune re sponse	IMP	biological_process
GO:0042130	negative regulation of T cell proliferation	IMP	biological_process
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051262	protein tetramerization	IDA	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:2001179	regulation of interleukin -10 secretion	IDA	biological_process
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological_process
GO:0002437	inflammatory response to antigenic stimulus	IDA	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006955	immune response	TAS	biological_process
GO:0006955	immune response	IDA	biological_process
GO:0006955	immune response	IDA	biological_process
GO:0006955	immune response	IMP	biological_process
GO:0009897	external side of plasma m embrane	IDA	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	TAS	cellular_component
GO:0016045	detection of bacterium	IMP	biological_process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032395	MHC class II receptor act ivity	TAS	molecular_function
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032673	regulation of interleukin -4 production	IDA	biological_process
GO:0032689	negative regulation of in terferon-gamma production	IMP	biological_process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	IMP	biological_process
GO:0042088	T-helper 1 type immune re sponse	IMP	biological_process
GO:0042130	negative regulation of T cell proliferation	IMP	biological_process
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051262	protein tetramerization	IDA	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:2001179	regulation of interleukin -10 secretion	IDA	biological_process
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002506	polysaccharide assembly w ith MHC class II protein complex	IDA	biological_process
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0023026	MHC class II protein comp lex binding	IDA	molecular_function
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002376	immune system process	IEA	biological_process
GO:0002504	antigen processing and pr esentation of peptide or polysaccharide antigen vi a MHC class II	IEA	biological_process
GO:0002506	polysaccharide assembly w ith MHC class II protein complex	IDA	biological_process
GO:0005764	lysosome	IEA	cellular_component
GO:0005765	lysosomal membrane	IEA	cellular_component
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005768	endosome	IEA	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006955	immune response	IEA	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0010008	endosome membrane	IEA	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0019882	antigen processing and pr esentation	IEA	biological_process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0023026	MHC class II protein comp lex binding	IDA	molecular_function
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IEA	cellular_component
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002506	polysaccharide assembly w ith MHC class II protein complex	IDA	biological_process
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0023026	MHC class II protein comp lex binding	IDA	molecular_function
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological_process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological_process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological_process
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002376	immune system process	IEA	biological_process
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological_process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological_process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological_process
GO:0002504	antigen processing and pr esentation of peptide or polysaccharide antigen vi a MHC class II	IEA	biological_process
GO:0005764	lysosome	IEA	cellular_component
GO:0005765	lysosomal membrane	IEA	cellular_component
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005768	endosome	IEA	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006955	immune response	IEA	biological_process
GO:0010008	endosome membrane	IEA	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0019882	antigen processing and pr esentation	IEA	biological_process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IEA	cellular_component
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	IDA	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	IDA	biological_process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological_process
GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA	biological_process
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042605	peptide antigen binding	IDA	molecular_function
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0042613	MHC class II protein comp lex	IDA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	ISS	biological_process
GO:0002437	inflammatory response to antigenic stimulus	ISS	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	ISS	biological_process
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006955	immune response	ISS	biological_process
GO:0006955	immune response	NAS	biological_process
GO:0009897	external side of plasma m embrane	ISS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	NAS	cellular_component
GO:0016045	detection of bacterium	ISS	biological_process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032395	MHC class II receptor act ivity	NAS	molecular_function
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032673	regulation of interleukin -4 production	ISS	biological_process
GO:0032689	negative regulation of in terferon-gamma production	ISS	biological_process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	ISS	biological_process
GO:0042088	T-helper 1 type immune re sponse	ISS	biological_process
GO:0042130	negative regulation of T cell proliferation	ISS	biological_process
GO:0042605	peptide antigen binding	ISS	molecular_function
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051262	protein tetramerization	ISS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:2001179	regulation of interleukin -10 secretion	ISS	biological_process
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002376	immune system process	IEA	biological_process
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	ISS	biological_process
GO:0002437	inflammatory response to antigenic stimulus	ISS	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	ISS	biological_process
GO:0002504	antigen processing and pr esentation of peptide or polysaccharide antigen vi a MHC class II	IEA	biological_process
GO:0005764	lysosome	IEA	cellular_component
GO:0005765	lysosomal membrane	IEA	cellular_component
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005768	endosome	IEA	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006955	immune response	IEA	biological_process
GO:0006955	immune response	ISS	biological_process
GO:0006955	immune response	NAS	biological_process
GO:0009897	external side of plasma m embrane	ISS	cellular_component
GO:0010008	endosome membrane	IEA	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	NAS	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016045	detection of bacterium	ISS	biological_process
GO:0019882	antigen processing and pr esentation	IEA	biological_process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IEA	cellular_component
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032395	MHC class II receptor act ivity	NAS	molecular_function
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032673	regulation of interleukin -4 production	ISS	biological_process
GO:0032689	negative regulation of in terferon-gamma production	ISS	biological_process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	ISS	biological_process
GO:0042088	T-helper 1 type immune re sponse	ISS	biological_process
GO:0042130	negative regulation of T cell proliferation	ISS	biological_process
GO:0042605	peptide antigen binding	ISS	molecular_function
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0042613	MHC class II protein comp lex	IEA	cellular_component
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051262	protein tetramerization	ISS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:2001179	regulation of interleukin -10 secretion	ISS	biological_process
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0000139	Golgi membrane	TAS	cellular_component
GO:0002381	immunoglobulin production involved in immunoglobul in mediated immune respon se	ISS	biological_process
GO:0002437	inflammatory response to antigenic stimulus	ISS	biological_process
GO:0002455	humoral immune response m ediated by circulating im munoglobulin	ISS	biological_process
GO:0005765	lysosomal membrane	IDA	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005765	lysosomal membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006955	immune response	ISS	biological_process
GO:0006955	immune response	NAS	biological_process
GO:0009897	external side of plasma m embrane	ISS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0012507	ER to Golgi transport ves icle membrane	TAS	cellular_component
GO:0016020	membrane	NAS	cellular_component
GO:0016045	detection of bacterium	ISS	biological_process
GO:0019886	antigen processing and pr esentation of exogenous p eptide antigen via MHC cl ass II	TAS	biological_process
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030658	transport vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031902	late endosome membrane	IDA	cellular_component
GO:0032395	MHC class II receptor act ivity	NAS	molecular_function
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032588	trans-Golgi network membr ane	TAS	cellular_component
GO:0032673	regulation of interleukin -4 production	ISS	biological_process
GO:0032689	negative regulation of in terferon-gamma production	ISS	biological_process
GO:0035774	positive regulation of in sulin secretion involved in cellular response to g lucose stimulus	ISS	biological_process
GO:0042088	T-helper 1 type immune re sponse	ISS	biological_process
GO:0042130	negative regulation of T cell proliferation	ISS	biological_process
GO:0042605	peptide antigen binding	ISS	molecular_function
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051262	protein tetramerization	ISS	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:0071556	integral component of lum enal side of endoplasmic reticulum membrane	TAS	cellular_component
GO:2001179	regulation of interleukin -10 secretion	ISS	biological_process

KEGG pathways

hsa05166  HTLV-I infection
hsa05152  Tuberculosis
hsa05168  Herpes simplex infection
hsa05169  Epstein-Barr virus infection
hsa05164  Influenza A
hsa05145  Toxoplasmosis
hsa04659  Th17 cell differentiation
hsa04514  Cell adhesion molecules
hsa04145  Phagosome
hsa05323  Rheumatoid arthritis
hsa05321  Inflammatory bowel disease
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa05140  Leishmaniasis
hsa04612  Antigen processing and presentation
hsa05332  Graft-versus-host disease
hsa05320  Autoimmune thyroid disease
hsa05416  Viral myocarditis
hsa05322  Systemic lupus erythematosus
hsa05330  Allograft rejection
hsa04940  Type I diabetes mellitus
hsa04672  Intestinal immune network for IgA production
hsa05150  Staphylococcus aureus infection
hsa05310  Asthma

Diseases

Associated diseases	References
Addison's disease	PMID: 16849401
Adrenal hyperplasia	PMID: 19201236
Allergies	PMID: 12144625
Alzheimer's disease	PMID: 10568518
Anemia	PMID: 18689790
Ankylosing spondylitis	PMID: 12118167
Antiphospholipid syndrome	PMID: 11157139
Arthritis	PMID: 12124858
Asthma	KEGG: H00079
Atopy	PMID: 10452762
Attention-deficit hyperactivity disorder (ADHD)	PMID: 19144284
Autism	PMID: 8765331
Autoimmune thyroid disease (AITD)	PMID: 11678832
Azoospermia	PMID: 12366783
Behcet's disease	PMID: 19038507
Cardiomyopathy	PMID: 15192840
Celiac disease	PMID: 16540751
Colorectal cancer	PMID: 19251712
Crohn's disease	PMID: 18521924
Cryptorchidism	PMID: 21955839
Dermatomyositis	PMID: 18930994
Diabetes	KEGG: H00408, PMID: 7914753
Diabetic retinopathy	PMID: 12694588
Diffuse panbronchiolitis	PMID: 18846964
Dilated cardiomyopathy	KEGG: H00294
Dystonia	PMID: 14581671
Endometriosis	PMID: 6594014
Endometriosis	PMID: 12392856
Epilepsy	PMID: 1396421
Eye diseases	PMID: 18385790
Female infertility	PMID: 10708242
Giant cell arteritis	KEGG: H01698
Glomerulonephritis	PMID: 14617034
Gonadal dysgenesis	PMID: 7834897
Goodpasture's disease	PMID: 15199166
Graves disease	KEGG: H00082
Guillain-Barre syndrome	PMID: 11776098
Hashimoto's thyroiditis	KEGG: H00081
Hemochromatosis	PMID: 3569756
Hemoglobinuria	PMID: 18396213
Hemophilia A	PMID: 15357778
Immune infertility	PMID: 10708242
Inflammatory bowel disease	PMID: 12656131
Juvenile arthritis	PMID: 15641099
Liver disease	PMID: 15185301
Macular degeneration	PMID: 15851575
Male infertility	PMID: 10611211
Meniere disease	PMID: 17592398
Multiple sclerosis	KEGG: H01490
Myasthenia gravis	PMID: 12770797
Myasthenia gravis	PMID: 16769963
Myopathy	PMID: 12124873
Myositis	PMID: 14648147
Myositis	PMID: 16507114
Nasal polyposis	PMID: 17305280
Nephrotic syndrome	PMID: 17180363
Neuropathy	PMID: 16053028
Non-obstructive azoospermia (NOA)	PMID: 10452599
Osteoporosis	PMID: 17498269
Ovarian endometriosis	PMID: 15665016
Pancreatitis	PMID: 11984513
Pemphigus	PMID: 18780165
Periodontitis	PMID: 15269854
Polyangiitis	PMID: 12858454
Polyangiitis	PMID: 16208405
Polycystic ovary syndrome (PCOS)	PMID: 2347091
Polyendocrinopathies	PMID: 18390988
Polymyositis	PMID: 15022353
Polyneuropathies	PMID: 18789688
Preeclampsia	PMID: 18593440
Preeclampsia	PMID: 2572795
Endometriosis associated infertility	INFBASE12658786
Adenomyosis	INFBASE11836687
Endometriosis	INFBASE11836687
Premature ovarian failure(POF)	PMID: 10084595
Primary ovarian insufficiency (POI)	PMID: 21811055
Proteinuria	PMID: 18449568
Psoriasis	PMID: 11872240
Pulmonary sarcoidosis	PMID: 12600814
Recurrent miscarriage	PMID: 15476187
Recurrent respiratory papillomatosis	PMID: 14976605
Recurrent pregnancy loss (RPL)/ Abortion/ Miscarriage/ Recurrent pregnancy failure/Pregnancy loss/ Recurrent miscarriage/ Spontaneous abortion	PMID: 8839135
Rheumatic diseases	PMID: 15124939
Rheumatic heart disease	PMID: 14680508
Rhinitis	PMID: 12764804
Sarcoidosis	PMID: 12694574
Schizophrenia	PMID: 11920855
Scleroderma	PMID: 11393660
Severe Acute Respiratory Syndrome	PMID: 19445991
Severe spermatogenic impairment	PMID: 14718045
Sickle cell anemia	PMID: 11872237
Sjogren's syndrome	KEGG: H01502
Spermatogenetic defects	PMID: 2609327
Spermatogenetic defects	PMID: 26662397
Stomatitis	PMID: 19046300
Systemic sclerosis	KEGG: H01492
Thryoiditis	PMID: 15305234
Trachoma	PMID: 18824733
Turner Syndrome (TS)	PMID: 8082315
Ulcerative colitis	PMID: 17301827
Unexplained infertility	PMID: 10668156
Urticaria	PMID: 16201295
Vitiligo	PMID: 17021767
Vogt-Koyanagi-Harada syndrome	KEGG: H01504

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
11870103	Endometrio sis	HLA-DRB1*1403		83 patients wit h endometriosis			Show abstract
17531990	Endometrio sis		Japanes e	129 (64 Japanes e endometriosis patients, 65 w omen with other laparoscopic d iagnoses)	Female infertility	HLA-ABC HLA-DR IFN-gamma	Show abstract
15831297	Endometrio sis		Japanes e	97 (38 Japanese women with end ometriosis, 59 with control su bjects)		HLA-ABC HLA-DR	Show abstract
12658786	Endometrio sis			38 (19 infertil e patients with endometriosis, 19 infertile p atients without endometriosis were studied as controls)	Female infertility	HLA-DR	Show abstract
12126569	Endometrio sis	HLA-DRB1 * 15		90 (40 surgical ly proven Endom etriosis patien ts, 50 normal c ontrol)			Show abstract
11836687	Endometrio sis	HLA-DQA10301 and 0401		140 (51 cases o f endometriosis , 45 cases of a denomyosis, 44 normal individu als as the cont rol)			Show abstract
20797713	Endometrio sis	CCL21 (rs2812378), HLA-DRB1 (rs660895)	Caucasi an	1,149 samples ( 798 patients wi th endometriosi s (176 minimal stage endometri osis, 116 mild endometriosis, 88 moderate sta ge endometriosi s, 179 severe s tage endometrio sis ) and 351 c ontrols)	Female infertility		Show abstract