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Gene id

332

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

BIRC5 Gene UCSC Ensembl

Aliases

API4, EPR-1

Gene name

baculoviral IAP repeat containing 5

Alternate names

baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, apoptosis inhibitor survivin, survivin variant 3 alpha,

Gene location

17q25.3 (78214195: 78225634) Exons: 6 NC_000017.11

Gene summary(Entrez)

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

OMIM

603352

Protein Summary

Protein general information

O15392

Name: Baculoviral IAP repeat containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)

Length: 142 Mass: 16,389

Tissue specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carc

Sequence

MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIE
EHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD

Structural information

Interpro:	IPR001370
Prosite:	PS50143
Pfam:	PF00653
CDD:	cd00022
PDB:	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
PDBsum:	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
DIP:	34662
MINT:	147138

Other Databases

GeneCards: BIRC5; Malacards: BIRC5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000086	G2/M transition of mitoti c cell cycle	IDA	biological_process
GO:0000228	nuclear chromosome	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000777	condensed chromosome kine tochore	IDA	cellular_component
GO:0000910	cytokinesis	IMP	biological_process
GO:0004842	ubiquitin-protein transfe rase activity	IBA	molecular_function
GO:0004869	cysteine-type endopeptida se inhibitor activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005814	centriole	IDA	cellular_component
GO:0005819	spindle	IEA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005874	microtubule	IEA	cellular_component
GO:0005876	spindle microtubule	IDA	cellular_component
GO:0005876	spindle microtubule	IDA	cellular_component
GO:0005881	cytoplasmic microtubule	IDA	cellular_component
GO:0006351	transcription, DNA-templa ted	IEA	biological_process
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0007062	sister chromatid cohesion	TAS	biological_process
GO:0007067	mitotic nuclear division	TAS	biological_process
GO:0008017	microtubule binding	TAS	molecular_function
GO:0008017	microtubule binding	IDA	molecular_function
GO:0008270	zinc ion binding	IDA	molecular_function
GO:0008270	zinc ion binding	NAS	molecular_function
GO:0008284	positive regulation of ce ll proliferation	TAS	biological_process
GO:0008536	Ran GTPase binding	IPI	molecular_function
GO:0009966	regulation of signal tran sduction	IBA	biological_process
GO:0015631	tubulin binding	IDA	molecular_function
GO:0016567	protein ubiquitination	IEA	biological_process
GO:0016925	protein sumoylation	TAS	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0031021	interphase microtubule or ganizing center	IDA	cellular_component
GO:0031503	protein complex localizat ion	IMP	biological_process
GO:0031536	positive regulation of ex it from mitosis	IMP	biological_process
GO:0031577	spindle checkpoint	IMP	biological_process
GO:0032133	chromosome passenger comp lex	IPI	cellular_component
GO:0032133	chromosome passenger comp lex	IPI	cellular_component
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0042803	protein homodimerization activity	IPI	molecular_function
GO:0042981	regulation of apoptotic p rocess	TAS	biological_process
GO:0043027	cysteine-type endopeptida se inhibitor activity inv olved in apoptotic proces s	IMP	molecular_function
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IMP	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IMP	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IMP	biological_process
GO:0045931	positive regulation of mi totic cell cycle	IMP	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0048037	cofactor binding	IDA	molecular_function
GO:0050897	cobalt ion binding	NAS	molecular_function
GO:0051087	chaperone binding	IPI	molecular_function
GO:0051301	cell division	IEA	biological_process
GO:0051301	cell division	IMP	biological_process
GO:0051303	establishment of chromoso me localization	IMP	biological_process
GO:0090307	mitotic spindle assembly	IBA	biological_process
GO:1990001	inhibition of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IBA	biological_process
GO:0000086	G2/M transition of mitoti c cell cycle	IDA	biological_process
GO:0000228	nuclear chromosome	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IEA	cellular_component
GO:0000775	chromosome, centromeric r egion	IEA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000776	kinetochore	IEA	cellular_component
GO:0000777	condensed chromosome kine tochore	IEA	cellular_component
GO:0000777	condensed chromosome kine tochore	IDA	cellular_component
GO:0000910	cytokinesis	IMP	biological_process
GO:0004842	ubiquitin-protein transfe rase activity	IBA	molecular_function
GO:0004869	cysteine-type endopeptida se inhibitor activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005694	chromosome	IEA	cellular_component
GO:0005694	chromosome	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005814	centriole	IDA	cellular_component
GO:0005819	spindle	IEA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005856	cytoskeleton	IEA	cellular_component
GO:0005874	microtubule	IEA	cellular_component
GO:0005876	spindle microtubule	IDA	cellular_component
GO:0005876	spindle microtubule	IDA	cellular_component
GO:0005881	cytoplasmic microtubule	IDA	cellular_component
GO:0006351	transcription, DNA-templa ted	IEA	biological_process
GO:0006355	regulation of transcripti on, DNA-templated	IEA	biological_process
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0006915	apoptotic process	IEA	biological_process
GO:0007049	cell cycle	IEA	biological_process
GO:0007059	chromosome segregation	IEA	biological_process
GO:0007062	sister chromatid cohesion	TAS	biological_process
GO:0007067	mitotic nuclear division	IEA	biological_process
GO:0007067	mitotic nuclear division	TAS	biological_process
GO:0008017	microtubule binding	TAS	molecular_function
GO:0008017	microtubule binding	IDA	molecular_function
GO:0008270	zinc ion binding	IDA	molecular_function
GO:0008270	zinc ion binding	NAS	molecular_function
GO:0008284	positive regulation of ce ll proliferation	TAS	biological_process
GO:0008536	Ran GTPase binding	IPI	molecular_function
GO:0009966	regulation of signal tran sduction	IBA	biological_process
GO:0010466	negative regulation of pe ptidase activity	IEA	biological_process
GO:0015631	tubulin binding	IDA	molecular_function
GO:0016567	protein ubiquitination	IEA	biological_process
GO:0016925	protein sumoylation	TAS	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0030414	peptidase inhibitor activ ity	IEA	molecular_function
GO:0030496	midbody	IEA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0031021	interphase microtubule or ganizing center	IDA	cellular_component
GO:0031503	protein complex localizat ion	IMP	biological_process
GO:0031536	positive regulation of ex it from mitosis	IMP	biological_process
GO:0031577	spindle checkpoint	IMP	biological_process
GO:0032133	chromosome passenger comp lex	IPI	cellular_component
GO:0032133	chromosome passenger comp lex	IPI	cellular_component
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0042803	protein homodimerization activity	IPI	molecular_function
GO:0042981	regulation of apoptotic p rocess	TAS	biological_process
GO:0043027	cysteine-type endopeptida se inhibitor activity inv olved in apoptotic proces s	IMP	molecular_function
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IMP	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IMP	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IMP	biological_process
GO:0045931	positive regulation of mi totic cell cycle	IMP	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0048037	cofactor binding	IDA	molecular_function
GO:0050897	cobalt ion binding	NAS	molecular_function
GO:0051087	chaperone binding	IPI	molecular_function
GO:0051301	cell division	IEA	biological_process
GO:0051301	cell division	IMP	biological_process
GO:0051303	establishment of chromoso me localization	IMP	biological_process
GO:0090307	mitotic spindle assembly	IBA	biological_process
GO:1990001	inhibition of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IBA	biological_process
GO:0000086	G2/M transition of mitoti c cell cycle	IDA	biological_process
GO:0000228	nuclear chromosome	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000775	chromosome, centromeric r egion	IDA	cellular_component
GO:0000777	condensed chromosome kine tochore	IDA	cellular_component
GO:0000910	cytokinesis	IMP	biological_process
GO:0004842	ubiquitin-protein transfe rase activity	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005814	centriole	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005876	spindle microtubule	IDA	cellular_component
GO:0005876	spindle microtubule	IDA	cellular_component
GO:0005881	cytoplasmic microtubule	IDA	cellular_component
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0007062	sister chromatid cohesion	TAS	biological_process
GO:0007067	mitotic nuclear division	TAS	biological_process
GO:0008017	microtubule binding	TAS	molecular_function
GO:0008017	microtubule binding	IDA	molecular_function
GO:0008270	zinc ion binding	IDA	molecular_function
GO:0008270	zinc ion binding	NAS	molecular_function
GO:0008284	positive regulation of ce ll proliferation	TAS	biological_process
GO:0008536	Ran GTPase binding	IPI	molecular_function
GO:0009966	regulation of signal tran sduction	IBA	biological_process
GO:0015631	tubulin binding	IDA	molecular_function
GO:0016925	protein sumoylation	TAS	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0031021	interphase microtubule or ganizing center	IDA	cellular_component
GO:0031503	protein complex localizat ion	IMP	biological_process
GO:0031536	positive regulation of ex it from mitosis	IMP	biological_process
GO:0031577	spindle checkpoint	IMP	biological_process
GO:0032133	chromosome passenger comp lex	IPI	cellular_component
GO:0032133	chromosome passenger comp lex	IPI	cellular_component
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0042803	protein homodimerization activity	IDA	molecular_function
GO:0042803	protein homodimerization activity	IPI	molecular_function
GO:0042981	regulation of apoptotic p rocess	TAS	biological_process
GO:0043027	cysteine-type endopeptida se inhibitor activity inv olved in apoptotic proces s	IMP	molecular_function
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IMP	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IMP	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IMP	biological_process
GO:0045931	positive regulation of mi totic cell cycle	IMP	biological_process
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0046982	protein heterodimerizatio n activity	IDA	molecular_function
GO:0048037	cofactor binding	IDA	molecular_function
GO:0050897	cobalt ion binding	NAS	molecular_function
GO:0051087	chaperone binding	IPI	molecular_function
GO:0051301	cell division	IMP	biological_process
GO:0051303	establishment of chromoso me localization	IMP	biological_process
GO:0090307	mitotic spindle assembly	IBA	biological_process
GO:1990001	inhibition of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IBA	biological_process

KEGG pathways

hsa05200  Pathways in cancer
hsa05161  Hepatitis B
hsa04210  Apoptosis
hsa04390  Hippo signaling pathway
hsa01524  Platinum drug resistance
hsa05210  Colorectal cancer
hsa04215  Apoptosis

Diseases

Associated diseases	References
Cancer	PMID: 20057973
Endometrial cancer	PMID: 20798131
Endometriosis	PMID: 22065163
Male infertility	PMID: 15139971
Oligoasthenozoospermia	PMID: 19152933
Ovarian endometriosis	PMID: 16309234
Ovarian endometriosis	PMID: 16309234
Spermatogenetic defects	PMID: 15896468
Implantation defects	INFBASE23011643
Male factor�infertility	INFBASE17509581
Ovarian endometriosis	INFBASE16309234
Ovarian endometriosis	INFBASE16309234
Endometriosis	INFBASE11883311
Tubal factor infertility	PMID: 22958786

PubMed references

PMID	Condition	Population details	Associated_genes	Abstract
24661731	Endometrio sis	69 (30 with end ometriosis, 39 women undergoin g ICSI for male infertility)	WNT4 WNT5a WNT1 ?-catenin BMP4	Show abstract
22563025	Endometrio sis		CXCL8 CXCR1 PTEN AKT	Show abstract
11883311	Endometrio sis	20 (2 perineum endometriosis, 6 scar endometr iosis after ces arean section, 12 normal human endometrium)		Show abstract
16644787	Endometrio sis	58 (56 ectopic (16 peritoneal red and 16 peri toneal black le sions and 24 ov arian endometri omata) and 13 e utopic endometr ial tissues sur gically obtaine d from 42 women with endometri osis (group A), 16 control eut opic endometriu m from 16 women without endome	survivin-EX3 survivin	Show abstract
12107265	Endometrio sis	47 (35 women wi th endometriosi s, 12 women wit hout endometrio sis)	MMP-2 MMP-9 MT1-MMP survivin	Show abstract
22065163	Endometrio sis	60 (20 cases of ovarian, 20 ca ses of deep end ometriosis)	CA125 Survivin CA19	Show abstract
23011643	Endometrio sis	265 (194 patien ts affected by endometriosis, 71 patients wit h normal endome trium)	MMP-2 MT1-MMP TIMP-2	Show abstract
17509581	Endometrio sis	28 patients und erwent ovulatio n induction for IVF-ET perform ed because of t ubal infertilit y, male factor infertility, or endometriosis		Show abstract
16309234	Endometrio sis (ovari an)	26 ovarian endo metriotic cysts	survivin VEGF	Show abstract