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Gene id

3491

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

CYR61 Gene UCSC Ensembl

Aliases

CCN1, GIG1, IGFBP10

Gene name

cysteine rich angiogenic inducer 61

Alternate names

protein CYR61, CCN family member 1, IBP-10, IGF-binding protein 10, IGFBP-10, cysteine-rich heparin-binding protein 61, cysteine-rich, anigogenic inducer, 61, insulin-like growth factor-binding protein 10,

Gene location

1p22.3 (85580760: 85583966) Exons: 5 NC_000001.11

Gene summary(Entrez)

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

OMIM

602369

Protein Summary

Protein general information

O00622

Name: Protein CYR61 (CCN family member 1) (Cysteine rich angiogenic inducer 61) (Insulin like growth factor binding protein 10) (IBP 10) (IGF binding protein 10) (IGFBP 10) (Protein GIG1)

Length: 381 Mass: 42,027

Sequence

MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKG
LECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRL
VKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQ
GQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY
AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFND
IHKFRD

Structural information

Protein Domains	IGFBP (25-94) VWFC. (98-164) TSP (228-273) CTCK. (286-360)
Interpro:	IPR006207 IPR006208 IPR009030 IPR000867 IPR012395 IPR017891 IPR000884 IPR001007
Prosite:	PS01185 PS01225 PS00222 PS51323 PS50092 PS01208 PS50184
Pfam:	PF00007 PF00219 PF00093
PDB:	4D0Z 4D11
PDBsum:	4D0Z 4D11
MINT:	4993925
STRING:	ENSP00000398736;

Other Databases

GeneCards: CYR61; Malacards: CYR61

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001558	regulation of cell growth	IEA	biological_process
GO:0001649	osteoblast differentiatio n	IEA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0002041	intussusceptive angiogene sis	IEA	biological_process
GO:0003181	atrioventricular valve mo rphogenesis	IEA	biological_process
GO:0003278	apoptotic process involve d in heart morphogenesis	IEA	biological_process
GO:0003281	ventricular septum develo pment	IEA	biological_process
GO:0005178	integrin binding	IBA	molecular_function
GO:0005520	insulin-like growth facto r binding	IEA	molecular_function
GO:0005578	proteinaceous extracellul ar matrix	IBA	cellular_component
GO:0006935	chemotaxis	IEA	biological_process
GO:0007155	cell adhesion	IBA	biological_process
GO:0007267	cell-cell signaling	IBA	biological_process
GO:0008201	heparin binding	IBA	molecular_function
GO:0008283	cell proliferation	TAS	biological_process
GO:0009653	anatomical structure morp hogenesis	TAS	biological_process
GO:0010518	positive regulation of ph ospholipase activity	IEA	biological_process
GO:0010811	positive regulation of ce ll-substrate adhesion	IEA	biological_process
GO:0030198	extracellular matrix orga nization	IEA	biological_process
GO:0030335	positive regulation of ce ll migration	IDA	biological_process
GO:0030513	positive regulation of BM P signaling pathway	IGI	biological_process
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0033690	positive regulation of os teoblast proliferation	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IEA	biological_process
GO:0044319	wound healing, spreading of cells	IDA	biological_process
GO:0045669	positive regulation of os teoblast differentiation	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0050840	extracellular matrix bind ing	IEA	molecular_function
GO:0060413	atrial septum morphogenes is	IEA	biological_process
GO:0060548	negative regulation of ce ll death	IBA	biological_process
GO:0060591	chondroblast differentiat ion	IEA	biological_process
GO:0060710	chorio-allantoic fusion	IEA	biological_process
GO:0060716	labyrinthine layer blood vessel development	IEA	biological_process
GO:0061036	positive regulation of ca rtilage development	IEA	biological_process
GO:0070372	regulation of ERK1 and ER K2 cascade	IDA	biological_process
GO:0072593	reactive oxygen species m etabolic process	IEA	biological_process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	IEA	biological_process
GO:0001558	regulation of cell growth	IEA	biological_process
GO:0001649	osteoblast differentiatio n	IEA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0002041	intussusceptive angiogene sis	IEA	biological_process
GO:0003181	atrioventricular valve mo rphogenesis	IEA	biological_process
GO:0003278	apoptotic process involve d in heart morphogenesis	IEA	biological_process
GO:0003281	ventricular septum develo pment	IEA	biological_process
GO:0005178	integrin binding	IEA	molecular_function
GO:0005178	integrin binding	IBA	molecular_function
GO:0005520	insulin-like growth facto r binding	IEA	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005578	proteinaceous extracellul ar matrix	IBA	cellular_component
GO:0006935	chemotaxis	IEA	biological_process
GO:0007155	cell adhesion	IEA	biological_process
GO:0007155	cell adhesion	IBA	biological_process
GO:0007155	cell adhesion	IEA	biological_process
GO:0007267	cell-cell signaling	IBA	biological_process
GO:0008201	heparin binding	IBA	molecular_function
GO:0008201	heparin binding	IEA	molecular_function
GO:0008283	cell proliferation	TAS	biological_process
GO:0009653	anatomical structure morp hogenesis	TAS	biological_process
GO:0010518	positive regulation of ph ospholipase activity	IEA	biological_process
GO:0010811	positive regulation of ce ll-substrate adhesion	IEA	biological_process
GO:0016337	single organismal cell-ce ll adhesion	IEA	biological_process
GO:0019838	growth factor binding	IEA	molecular_function
GO:0030198	extracellular matrix orga nization	IEA	biological_process
GO:0030335	positive regulation of ce ll migration	IEA	biological_process
GO:0030335	positive regulation of ce ll migration	IDA	biological_process
GO:0030513	positive regulation of BM P signaling pathway	IGI	biological_process
GO:0031012	extracellular matrix	IEA	cellular_component
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0033690	positive regulation of os teoblast proliferation	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IEA	biological_process
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IEA	biological_process
GO:0044319	wound healing, spreading of cells	IDA	biological_process
GO:0045597	positive regulation of ce ll differentiation	IEA	biological_process
GO:0045669	positive regulation of os teoblast differentiation	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0050840	extracellular matrix bind ing	IEA	molecular_function
GO:0060413	atrial septum morphogenes is	IEA	biological_process
GO:0060548	negative regulation of ce ll death	IBA	biological_process
GO:0060591	chondroblast differentiat ion	IEA	biological_process
GO:0060710	chorio-allantoic fusion	IEA	biological_process
GO:0060716	labyrinthine layer blood vessel development	IEA	biological_process
GO:0061036	positive regulation of ca rtilage development	IEA	biological_process
GO:0070372	regulation of ERK1 and ER K2 cascade	IDA	biological_process
GO:0072593	reactive oxygen species m etabolic process	IEA	biological_process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	IEA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0005178	integrin binding	IBA	molecular_function
GO:0005578	proteinaceous extracellul ar matrix	IBA	cellular_component
GO:0007155	cell adhesion	IBA	biological_process
GO:0007267	cell-cell signaling	IBA	biological_process
GO:0008201	heparin binding	IBA	molecular_function
GO:0008283	cell proliferation	TAS	biological_process
GO:0009653	anatomical structure morp hogenesis	TAS	biological_process
GO:0030335	positive regulation of ce ll migration	IDA	biological_process
GO:0030513	positive regulation of BM P signaling pathway	IGI	biological_process
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0033690	positive regulation of os teoblast proliferation	IDA	biological_process
GO:0044319	wound healing, spreading of cells	IDA	biological_process
GO:0045669	positive regulation of os teoblast differentiation	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0060548	negative regulation of ce ll death	IBA	biological_process
GO:0070372	regulation of ERK1 and ER K2 cascade	IDA	biological_process

Diseases

Associated diseases	References
Cancer	PMID: 18950845
Endometrial cancer	PMID: 15471875
Endometriosis	PMID: 15044605
Polycystic ovary syndrome (PCOS)	PMID: 17601910
Endometriosis	INFBASE15044605

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
15044605	Endometrio sis					Cyr61	Show abstract