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Gene id

3576

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

CXCL8 Gene UCSC Ensembl

Aliases

GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1

Gene name

C-X-C motif chemokine ligand 8

Alternate names

interleukin-8, T-cell chemotactic factor, alveolar macrophage chemotactic factor I, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, int,

Gene location

4q13.3 (73740505: 73743715) Exons: 4 NC_000004.12

Gene summary(Entrez)

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

OMIM

146930

Protein Summary

Protein general information

P10145

Name: Interleukin 8 (IL 8) (C X C motif chemokine 8) (Chemokine (C X C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP 1) (Monocyte derived neutrophil chemotactic factor) (MDNCF) (Monocyte derived neutrophil activating peptide) (MONAP) (Ne

Length: 99 Mass: 11,098

Sequence

MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRE
LCLDPKENWVQRVVEKFLKRAENS

Structural information

Interpro:	IPR001089 IPR018048 IPR001811 IPR033899 IPR028469
Prosite:	PS00471
Pfam:	PF00048
CDD:	cd00273
PDB:	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14
PDBsum:	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14
DIP:	3778
MINT:	1516890
STRING:	ENSP00000306512;

Other Databases

GeneCards: CXCL8; Malacards: CXCL8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001525	angiogenesis	TAS	biological_process
GO:0002237	response to molecule of b acterial origin	IDA	biological_process
GO:0005153	interleukin-8 receptor bi nding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0006935	chemotaxis	TAS	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0006955	immune response	IBA	biological_process
GO:0007050	cell cycle arrest	IDA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	TAS	biological_process
GO:0008009	chemokine activity	TAS	molecular_function
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0019722	calcium-mediated signalin g	TAS	biological_process
GO:0030155	regulation of cell adhesi on	IDA	biological_process
GO:0030593	neutrophil chemotaxis	IGI	biological_process
GO:0031623	receptor internalization	IDA	biological_process
GO:0034976	response to endoplasmic r eticulum stress	IDA	biological_process
GO:0035556	intracellular signal tran sduction	IDA	biological_process
GO:0036499	PERK-mediated unfolded pr otein response	TAS	biological_process
GO:0042119	neutrophil activation	TAS	biological_process
GO:0044344	cellular response to fibr oblast growth factor stim ulus	IEP	biological_process
GO:0045091	regulation of single stra nded viral RNA replicatio n via double stranded DNA intermediate	IDA	biological_process
GO:0045744	negative regulation of G- protein coupled receptor protein signaling pathway	IDA	biological_process
GO:0045766	positive regulation of an giogenesis	IDA	biological_process
GO:0048566	embryonic digestive tract development	IEP	biological_process
GO:0050930	induction of positive che motaxis	IGI	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0071222	cellular response to lipo polysaccharide	IDA	biological_process
GO:0071347	cellular response to inte rleukin-1	IEP	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IEP	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	TAS	biological_process
GO:0001525	angiogenesis	TAS	biological_process
GO:0002237	response to molecule of b acterial origin	IDA	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005153	interleukin-8 receptor bi nding	IEA	molecular_function
GO:0005153	interleukin-8 receptor bi nding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	TAS	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0006935	chemotaxis	IEA	biological_process
GO:0006935	chemotaxis	TAS	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0006955	immune response	IBA	biological_process
GO:0007050	cell cycle arrest	IDA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	TAS	biological_process
GO:0008009	chemokine activity	IEA	molecular_function
GO:0008009	chemokine activity	TAS	molecular_function
GO:0008009	chemokine activity	TAS	molecular_function
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0019722	calcium-mediated signalin g	TAS	biological_process
GO:0030155	regulation of cell adhesi on	IDA	biological_process
GO:0030593	neutrophil chemotaxis	IEA	biological_process
GO:0030593	neutrophil chemotaxis	IGI	biological_process
GO:0031623	receptor internalization	IDA	biological_process
GO:0034976	response to endoplasmic r eticulum stress	IDA	biological_process
GO:0035556	intracellular signal tran sduction	IDA	biological_process
GO:0036499	PERK-mediated unfolded pr otein response	TAS	biological_process
GO:0042119	neutrophil activation	IEA	biological_process
GO:0042119	neutrophil activation	TAS	biological_process
GO:0044344	cellular response to fibr oblast growth factor stim ulus	IEP	biological_process
GO:0045091	regulation of single stra nded viral RNA replicatio n via double stranded DNA intermediate	IDA	biological_process
GO:0045744	negative regulation of G- protein coupled receptor protein signaling pathway	IDA	biological_process
GO:0045766	positive regulation of an giogenesis	IDA	biological_process
GO:0048566	embryonic digestive tract development	IEP	biological_process
GO:0050930	induction of positive che motaxis	IGI	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0071222	cellular response to lipo polysaccharide	IDA	biological_process
GO:0071347	cellular response to inte rleukin-1	IEP	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IEP	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	TAS	biological_process
GO:0001525	angiogenesis	TAS	biological_process
GO:0002237	response to molecule of b acterial origin	IDA	biological_process
GO:0005153	interleukin-8 receptor bi nding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	TAS	cellular_component
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0006935	chemotaxis	TAS	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0006955	immune response	IBA	biological_process
GO:0007050	cell cycle arrest	IDA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	TAS	biological_process
GO:0008009	chemokine activity	TAS	molecular_function
GO:0008009	chemokine activity	TAS	molecular_function
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0019722	calcium-mediated signalin g	TAS	biological_process
GO:0030155	regulation of cell adhesi on	IDA	biological_process
GO:0030593	neutrophil chemotaxis	IGI	biological_process
GO:0031623	receptor internalization	IDA	biological_process
GO:0034976	response to endoplasmic r eticulum stress	IDA	biological_process
GO:0035556	intracellular signal tran sduction	IDA	biological_process
GO:0036499	PERK-mediated unfolded pr otein response	TAS	biological_process
GO:0042119	neutrophil activation	TAS	biological_process
GO:0044344	cellular response to fibr oblast growth factor stim ulus	IEP	biological_process
GO:0045091	regulation of single stra nded viral RNA replicatio n via double stranded DNA intermediate	IDA	biological_process
GO:0045744	negative regulation of G- protein coupled receptor protein signaling pathway	IDA	biological_process
GO:0045766	positive regulation of an giogenesis	IDA	biological_process
GO:0048566	embryonic digestive tract development	IEP	biological_process
GO:0050930	induction of positive che motaxis	IGI	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0071222	cellular response to lipo polysaccharide	IDA	biological_process
GO:0071347	cellular response to inte rleukin-1	IEP	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IEP	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	TAS	biological_process

KEGG pathways

hsa05200  Pathways in cancer
hsa04060  Cytokine-cytokine receptor interaction
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05161  Hepatitis B
hsa04062  Chemokine signaling pathway
hsa05164  Influenza A
hsa05202  Transcriptional misregulation in cancer
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04621  NOD-like receptor signaling pathway
hsa05142  Chagas disease
hsa04657  IL-17 signaling pathway
hsa04932  Non-alcoholic fatty liver disease
hsa05160  Hepatitis C
hsa05323  Rheumatoid arthritis
hsa04072  Phospholipase D signaling pathway
hsa04620  Toll-like receptor signaling pathway
hsa05146  Amoebiasis
hsa05133  Pertussis
hsa04064  NF-kappa B signaling pathway
hsa05134  Legionellosis
hsa05132  Salmonella infection
hsa05144  Malaria
hsa05219  Bladder cancer
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05131  Shigellosis
hsa04622  RIG-I-like receptor signaling pathway

Diseases

Associated diseases	References
Asthenozoospermia	PMID: 11839394
Azoospermia	PMID: 19811461
Endometriosis	PMID: 17706208
Endometriosis	PMID: 17688616
Immune infertility	PMID: 8792937
Leukocytospermia	PMID: 12749127
Male Infertility	PMID: 21244563
Oligozoospermia	PMID: 17341438
Ovarian endometriosis	PMID: 15005245
Ovarian endometriosis	PMID: 15005245
Ovarian endometriosis	PMID: 25797583
Ovarian hyperstimulation syndrome (OHSS)	PMID: 10783347
Polycystic ovary syndrome (PCOS)	PMID: 23900753
Ovarian endometriosis	INFBASE25797583
Endometriosis (ovarian)	INFBASE25797583
Endometrioma	INFBASE20074813
Endometriosis,Infertility	INFBASE20007161
Unexplained infertility	INFBASE17688616
Ovarian endometriosis	INFBASE15005245
Female infertility	INFBASE12566749
Ectopic endometriosis	INFBASE10087426
Endometriosis	INFBASE8612850
Poor ovarian response (POR)	PMID: 25083184
Prostate inflammatory diseases	PMID: 21738005
Repeated implantation failure (RIF)	PMID: 22201617
Endometriosis	INFBASE17706208

PubMed references

PMID	Condition	Population details	Infertility_type	Associated_genes	Abstract
17706208	Endometrio sis	141 (63 women w ith surgically confirmed stage II-IV endometr iosis, 78 women who were surgi cally confirmed to be free of endometriosis)		MIF MCP-1 INFG LEP CA-127	Show abstract
22563025	Endometrio sis			CXCL8 CXCR1 PTEN AKT	Show abstract
10087426	Endometrio sis			TNF-alpha IL-8	Show abstract
17688616	Endometrio sis	57 infertile wo men undergoing laparoscopy for unexplained in fertility	Female infertility	MCP-1 IL-8 PDGF IL-6 RANTES IL-1 beta TNF-alpha and sFas	Show abstract
25376627	Endometrio sis	65 (31 patients with endometri osis, 34 patien ts without endo metriosis)	Female infertility	GPX3 IL6 IL8 TNF TXN TBPL2	Show abstract
12566749	Endometrio sis	31 (26 women wi th infertility, 5 controls )	Female infertility		Show abstract
21848410	Endometrio sis	86 (58 women wi th endometriosi s and 28 women undergoing tuba l ligation)		Leptin IL-8	Show abstract
21601196	Endometrio sis			IL-17F IL-8 COX2	Show abstract
24133580	Endometrio sis			NME1 VEGF IL-8	Show abstract
15613411	Endometrio sis				Show abstract
20829186	Endometrio sis			MIF VEGF IL-8 MCP-1	Show abstract
15618253	Endometrio sis	79 (27 ectopic endometrium tis sues from women with endometri osis, 25 eutopi c endometrium from women with endometriosis, 27 endometrium from women wit hout endometrio sis)		IL-8 CXCR1 CXCR2	Show abstract
9591504	Endometrio sis	40 women who un derwent either laparoscopy or laparoscopic su rgery	Female infertility	IL-8	Show abstract
20007161	Endometrio sis	294 (93 women w ith a normal pe lvis, 201 women with endometri osis)	Female infertility	IL-6 IL-8 CA-125	Show abstract
17509205	Endometrio sis	75 (17 endometr iosis patients with ovarian in volvement, 33 p atients without ovarian involv ement, 25 witho ut endometriosi s)		IL-8 TNFalpha	Show abstract
18314120	Endometrio sis	75 (24 women wi th endometriosi s, 24 homologou s eutopic endom etrium, 27 wome n without endom etriosis)		IL-8 MCP-1	Show abstract
12445988	Endometrio sis	88 (32 controls , 56 endometrio sis patients)		IL-8	Show abstract
11776170	Endometrio sis	53 (31 cases wi th Endometriosi s, 22 cases wit hout endometrio sis )		IL-6 IL-8	Show abstract
15672963	Endometrio sis	63 women with v arious stages o f endometriosis		IL-6 b-FGF IL-8	Show abstract
9740457	Endometrio sis	50 consecutive patients underg oing laparoscop ic surgery for various gynaeco logical indicat ions (abdominal pain, infertil ity, sterilizat ion)		IL-8	Show abstract
8612850	Endometrio sis	25 (17 women wi th endometriosi s, 8 fertile co ntrols undergoi ng tubal ligati on)		TNF alpha IL-8 IL-10	Show abstract
20074813	Endometrio sis			IL-6 IL-8 IL-13 IL-17 and CA-125	Show abstract
15005245	Endometrio sis (ovari an)			FCER1G PGDS IL-8 GRO1 GRO2 CXCR4 MCP1 MMP COL4A2 and COL5A2	Show abstract
25797583	Endometrio sis (ovari an)	98 (58 women wi th ovarian endo metriosis (case s), 40 healthy women undergoin g sterilization or patients wi th benign ovari an cysts (contr ols))	Female infertility	IL6 IL8 PAEP LEP	Show abstract
21601196	Endometrio sis			IL-17F IL-8 COX2	Show abstract
28433374	Endometrio sis	107 female infe rtility (56 end ometriosis pati ents, 38 patien ts without endo metriosis)	Female infertility		Show abstract
27491770	Endometrio sis	340 (200 women with advanced s tage endometrio sis, 140 normal ovulating wome n with tubal fa ctor infertilit y (without endo metriosis))	Female infertility	IL1B TNFA IL2 IL8 IL12 IFNG IL4 IL6 IL10 VEGF ADM angiogenin	Show abstract