Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 3578
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol IL9   Gene   UCSC   Ensembl
Aliases HP40, IL-9, P40
Gene name interleukin 9
Alternate names interleukin-9, T-cell growth factor p40, cytokine P40, homolog of mouse T cell and mast cell growth factor 40, p40 T-cell and mast cell growth factor, p40 cytokine,
Gene location 5q31.1 (135895826: 135892245)     Exons: 5     NC_000005.10
Gene summary(Entrez) The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
OMIM 146931

Protein Summary

Protein general information P15248  

Name: Interleukin-9 (IL-9) (Cytokine P40) (T-cell growth factor P40)

Length: 144  Mass: 15,909

Sequence MLLAMVLTSALLLCSVAGQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQ
MTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI
Structural information
Interpro:  IPR018049 IPR000226 IPR020447
Prosite:   PS00255

Pfam:  
PF01415

DIP:  
3155
STRING:   ENSP00000274520;
Other Databases GeneCards:  IL9;  Malacards:  IL9

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005125 cytokine activity
IEA molecular_function
GO:0005140 interleukin-9 receptor bi
nding
IEA molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0006954 inflammatory response
TAS biological_process
GO:0006955 immune response
IEA biological_process
GO:0008083 growth factor activity
IEA molecular_function
GO:0008284 positive regulation of ce
ll proliferation
TAS biological_process
GO:0030307 positive regulation of ce
ll growth
IEA biological_process
GO:0045407 positive regulation of in
terleukin-5 biosynthetic
process
ISS biological_process
GO:0005125 cytokine activity
IEA molecular_function
GO:0005125 cytokine activity
IEA molecular_function
GO:0005126 cytokine receptor binding
IEA molecular_function
GO:0005140 interleukin-9 receptor bi
nding
IEA molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0006954 inflammatory response
TAS biological_process
GO:0006955 immune response
IEA biological_process
GO:0008083 growth factor activity
IEA molecular_function
GO:0008083 growth factor activity
IEA molecular_function
GO:0008284 positive regulation of ce
ll proliferation
TAS biological_process
GO:0030307 positive regulation of ce
ll growth
IEA biological_process
GO:0045407 positive regulation of in
terleukin-5 biosynthetic
process
IEA biological_process
GO:0045407 positive regulation of in
terleukin-5 biosynthetic
process
ISS biological_process
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0006954 inflammatory response
TAS biological_process
GO:0008284 positive regulation of ce
ll proliferation
TAS biological_process
GO:0045407 positive regulation of in
terleukin-5 biosynthetic
process
ISS biological_process

Diseases

Associated diseases References
Asthma PMID: 19536153
Brain Ischemia PMID: 19028820
Brain ischemia PMID: 19729601
Celiac disease PMID: 19845895
Chorioamnionitis PMID: 20452482
Coronary artery disease PMID: 18612209
Endometriosis PMID: 28433374
Hodgkin Disease PMID: 19573080
Lymphoma PMID: 18633131
Migraine disorders PMID: 19559392
Multiple myeloma PMID: 20568250
Multiple sclerosis PMID: 18563468
Endometriosis INFBASE28433374
Schizophrenia PMID: 18298822
Endometriosis PMID: 28433374

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
28433374 Endometrio
sis

107 female infe
rtility
Female infertility
Show abstract