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Gene id

3596

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

IL13 Gene UCSC Ensembl

Aliases

IL-13, P600

Gene name

interleukin 13

Alternate names

interleukin-13,

Gene location

5q31.1 (132658172: 132661108) Exons: 4 NC_000005.10

Gene summary(Entrez)

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

OMIM

147683

Protein Summary

Protein general information

P35225

Name: Interleukin 13 (IL 13)

Length: 146 Mass: 15,816

Sequence

MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAG
MYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

Structural information

Interpro:	IPR009079 IPR020470 IPR001325 IPR018096
Prosite:	PS00838
Pfam:	PF03487
PDB:	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y
PDBsum:	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y
DIP:	3224
STRING:	ENSP00000304915;

Other Databases

GeneCards: IL13; Malacards: IL13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001774	microglial cell activatio n	IEA	biological_process
GO:0002639	positive regulation of im munoglobulin production	IBA	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005144	interleukin-13 receptor b inding	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005615	extracellular space	ISS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0007165	signal transduction	NAS	biological_process
GO:0007267	cell-cell signaling	IC	biological_process
GO:0009897	external side of plasma m embrane	IEA	cellular_component
GO:0010155	regulation of proton tran sport	IEA	biological_process
GO:0030890	positive regulation of B cell proliferation	IBA	biological_process
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0032723	positive regulation of co nnective tissue growth fa ctor production	IEA	biological_process
GO:0033861	negative regulation of NA D(P)H oxidase activity	IEA	biological_process
GO:0035094	response to nicotine	IEA	biological_process
GO:0042526	positive regulation of ty rosine phosphorylation of Stat6 protein	IEA	biological_process
GO:0043032	positive regulation of ma crophage activation	IBA	biological_process
GO:0043306	positive regulation of ma st cell degranulation	IBA	biological_process
GO:0045471	response to ethanol	IEA	biological_process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IEA	biological_process
GO:0050714	positive regulation of pr otein secretion	IEA	biological_process
GO:0051281	positive regulation of re lease of sequestered calc ium ion into cytosol	IEA	biological_process
GO:0071260	cellular response to mech anical stimulus	IEA	biological_process
GO:0071345	cellular response to cyto kine stimulus	IBA	biological_process
GO:0071635	negative regulation of tr ansforming growth factor beta production	IEA	biological_process
GO:1901215	negative regulation of ne uron death	IEA	biological_process
GO:1901247	negative regulation of lu ng ciliated cell differen tiation	NAS	biological_process
GO:1901251	positive regulation of lu ng goblet cell differenti ation	NAS	biological_process
GO:1903660	negative regulation of co mplement-dependent cytoto xicity	IMP	biological_process
GO:2000231	positive regulation of pa ncreatic stellate cell pr oliferation	IEA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IMP	biological_process
GO:0001774	microglial cell activatio n	IEA	biological_process
GO:0002639	positive regulation of im munoglobulin production	IEA	biological_process
GO:0002639	positive regulation of im munoglobulin production	IBA	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005125	cytokine activity	TAS	molecular_function
GO:0005126	cytokine receptor binding	IEA	molecular_function
GO:0005144	interleukin-13 receptor b inding	IEA	molecular_function
GO:0005144	interleukin-13 receptor b inding	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	ISS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0007165	signal transduction	NAS	biological_process
GO:0007267	cell-cell signaling	IC	biological_process
GO:0009612	response to mechanical st imulus	IEA	biological_process
GO:0009897	external side of plasma m embrane	IEA	cellular_component
GO:0010155	regulation of proton tran sport	IEA	biological_process
GO:0030890	positive regulation of B cell proliferation	IEA	biological_process
GO:0030890	positive regulation of B cell proliferation	IBA	biological_process
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0032723	positive regulation of co nnective tissue growth fa ctor production	IEA	biological_process
GO:0033861	negative regulation of NA D(P)H oxidase activity	IEA	biological_process
GO:0035094	response to nicotine	IEA	biological_process
GO:0042526	positive regulation of ty rosine phosphorylation of Stat6 protein	IEA	biological_process
GO:0043032	positive regulation of ma crophage activation	IEA	biological_process
GO:0043032	positive regulation of ma crophage activation	IBA	biological_process
GO:0043270	positive regulation of io n transport	IEA	biological_process
GO:0043306	positive regulation of ma st cell degranulation	IEA	biological_process
GO:0043306	positive regulation of ma st cell degranulation	IBA	biological_process
GO:0045471	response to ethanol	IEA	biological_process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IEA	biological_process
GO:0050714	positive regulation of pr otein secretion	IEA	biological_process
GO:0051281	positive regulation of re lease of sequestered calc ium ion into cytosol	IEA	biological_process
GO:0071260	cellular response to mech anical stimulus	IEA	biological_process
GO:0071345	cellular response to cyto kine stimulus	IEA	biological_process
GO:0071345	cellular response to cyto kine stimulus	IBA	biological_process
GO:0071635	negative regulation of tr ansforming growth factor beta production	IEA	biological_process
GO:1901215	negative regulation of ne uron death	IEA	biological_process
GO:1901247	negative regulation of lu ng ciliated cell differen tiation	NAS	biological_process
GO:1901251	positive regulation of lu ng goblet cell differenti ation	NAS	biological_process
GO:1903660	negative regulation of co mplement-dependent cytoto xicity	IMP	biological_process
GO:2000231	positive regulation of pa ncreatic stellate cell pr oliferation	IEA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IMP	biological_process
GO:0002639	positive regulation of im munoglobulin production	IBA	biological_process
GO:0005125	cytokine activity	TAS	molecular_function
GO:0005144	interleukin-13 receptor b inding	IBA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005615	extracellular space	ISS	cellular_component
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0007165	signal transduction	NAS	biological_process
GO:0007267	cell-cell signaling	IC	biological_process
GO:0030890	positive regulation of B cell proliferation	IBA	biological_process
GO:0043032	positive regulation of ma crophage activation	IBA	biological_process
GO:0043306	positive regulation of ma st cell degranulation	IBA	biological_process
GO:0071345	cellular response to cyto kine stimulus	IBA	biological_process
GO:1901247	negative regulation of lu ng ciliated cell differen tiation	NAS	biological_process
GO:1901251	positive regulation of lu ng goblet cell differenti ation	NAS	biological_process
GO:1903660	negative regulation of co mplement-dependent cytoto xicity	IMP	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IMP	biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05162  Measles
hsa04657  IL-17 signaling pathway
hsa05321  Inflammatory bowel disease
hsa04658  Th1 and Th2 cell differentiation
hsa04664  Fc epsilon RI signaling pathway
hsa05310  Asthma

Diseases

Associated diseases	References
Allergic rhinitis	KEGG: H01360, OMIM: 147683
Asthma	KEGG: H00079
Atopic dermatitis	PMID: 12413765
Atopic dermatitis	KEGG: H01358
Atopy	PMID: 15969687
Bullous pemphigoid	PMID: 16403098
Cancer	PMID: 19773451
Chronic obstructive pulmonary disease (COPD)	PMID: 15596681
Coronary artery disease	PMID: 18612209
Crohn's disease	PMID: 17183946
Dermatitis	PMID: 16681592
Diabetes	PMID: 19479237
Endometriosis	PMID: 15255283
Erythema nodosum	PMID: 19225544
Gastric atrophy	PMID: 15904474
Graves disease	PMID: 14510917
Hodgkin disease	PMID: 22286212
Juvenile arthritis	PMID: 14564352
Lung disease	PMID: 12594065
Mastocytosis	PMID: 19178408
Migraine disorders	PMID: 19559392
Nephrotic syndrome	PMID: 11980568
Onchocerciasis	PMID: 11825773
Polycystic ovary syndrome (PCOS)	PMID: 12798884
Endometriosis	INFBASE9222022
Psoriasis	PMID: 17388919
Rheumatoid arthritis	PMID: 18625055
Rhinitis	PMID: 12928861
Sjogren's syndrome	PMID: 16166103

PubMed references

PMID	Condition	Population details	Infertility_type	Associated_genes	Abstract
15255283	Endometrio sis	80 women while they were under going laparosco py for pain,inf ertility, tubal ligation or re -anastomosis		IL-12 IL-13	Show abstract
12765345	Endometrio sis			IL-13 IL-15	Show abstract
9222022	Endometrio sis			IL-13	Show abstract
28433374	Endometrio sis	107 female infe rtility (56 end ometriosis pati ents, 38 patien ts without endo metriosis)	Female infertility		Show abstract