Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 3596
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol IL13   Gene   UCSC   Ensembl
Aliases IL-13, P600
Gene name interleukin 13
Alternate names interleukin-13,
Gene location 5q31.1 (132658172: 132661108)     Exons: 4     NC_000005.10
Gene summary(Entrez) This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
OMIM 147683

Protein Summary

Protein general information P35225  

Name: Interleukin 13 (IL 13)

Length: 146  Mass: 15,816

Sequence MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAG
MYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN
Structural information
Interpro:  IPR009079 IPR020470 IPR001325 IPR018096
Prosite:   PS00838

Pfam:  
PF03487

PDB:  
1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y
PDBsum:   1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y

DIP:  
3224
STRING:   ENSP00000304915;
Other Databases GeneCards:  IL13;  Malacards:  IL13

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001774 microglial cell activatio
n
IEA biological_process
GO:0002639 positive regulation of im
munoglobulin production
IBA biological_process
GO:0005125 cytokine activity
IEA molecular_function
GO:0005144 interleukin-13 receptor b
inding
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0005615 extracellular space
ISS cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0006928 movement of cell or subce
llular component
TAS biological_process
GO:0006954 inflammatory response
IEA biological_process
GO:0006955 immune response
IEA biological_process
GO:0007165 signal transduction
NAS biological_process
GO:0007267 cell-cell signaling
IC biological_process
GO:0009897 external side of plasma m
embrane
IEA cellular_component
GO:0010155 regulation of proton tran
sport
IEA biological_process
GO:0030890 positive regulation of B
cell proliferation
IBA biological_process
GO:0032496 response to lipopolysacch
aride
IEA biological_process
GO:0032723 positive regulation of co
nnective tissue growth fa
ctor production
IEA biological_process
GO:0033861 negative regulation of NA
D(P)H oxidase activity
IEA biological_process
GO:0035094 response to nicotine
IEA biological_process
GO:0042526 positive regulation of ty
rosine phosphorylation of
Stat6 protein
IEA biological_process
GO:0043032 positive regulation of ma
crophage activation
IBA biological_process
GO:0043306 positive regulation of ma
st cell degranulation
IBA biological_process
GO:0045471 response to ethanol
IEA biological_process
GO:0048661 positive regulation of sm
ooth muscle cell prolifer
ation
IEA biological_process
GO:0050714 positive regulation of pr
otein secretion
IEA biological_process
GO:0051281 positive regulation of re
lease of sequestered calc
ium ion into cytosol
IEA biological_process
GO:0071260 cellular response to mech
anical stimulus
IEA biological_process
GO:0071345 cellular response to cyto
kine stimulus
IBA biological_process
GO:0071635 negative regulation of tr
ansforming growth factor
beta production
IEA biological_process
GO:1901215 negative regulation of ne
uron death
IEA biological_process
GO:1901247 negative regulation of lu
ng ciliated cell differen
tiation
NAS biological_process
GO:1901251 positive regulation of lu
ng goblet cell differenti
ation
NAS biological_process
GO:1903660 negative regulation of co
mplement-dependent cytoto
xicity
IMP biological_process
GO:2000231 positive regulation of pa
ncreatic stellate cell pr
oliferation
IEA biological_process
GO:2000352 negative regulation of en
dothelial cell apoptotic
process
IMP biological_process
GO:0001774 microglial cell activatio
n
IEA biological_process
GO:0002639 positive regulation of im
munoglobulin production
IEA biological_process
GO:0002639 positive regulation of im
munoglobulin production
IBA biological_process
GO:0005125 cytokine activity
IEA molecular_function
GO:0005125 cytokine activity
TAS molecular_function
GO:0005126 cytokine receptor binding
IEA molecular_function
GO:0005144 interleukin-13 receptor b
inding
IEA molecular_function
GO:0005144 interleukin-13 receptor b
inding
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
ISS cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0006928 movement of cell or subce
llular component
TAS biological_process
GO:0006954 inflammatory response
IEA biological_process
GO:0006954 inflammatory response
TAS biological_process
GO:0006955 immune response
IEA biological_process
GO:0007165 signal transduction
NAS biological_process
GO:0007267 cell-cell signaling
IC biological_process
GO:0009612 response to mechanical st
imulus
IEA biological_process
GO:0009897 external side of plasma m
embrane
IEA cellular_component
GO:0010155 regulation of proton tran
sport
IEA biological_process
GO:0030890 positive regulation of B
cell proliferation
IEA biological_process
GO:0030890 positive regulation of B
cell proliferation
IBA biological_process
GO:0032496 response to lipopolysacch
aride
IEA biological_process
GO:0032723 positive regulation of co
nnective tissue growth fa
ctor production
IEA biological_process
GO:0033861 negative regulation of NA
D(P)H oxidase activity
IEA biological_process
GO:0035094 response to nicotine
IEA biological_process
GO:0042526 positive regulation of ty
rosine phosphorylation of
Stat6 protein
IEA biological_process
GO:0043032 positive regulation of ma
crophage activation
IEA biological_process
GO:0043032 positive regulation of ma
crophage activation
IBA biological_process
GO:0043270 positive regulation of io
n transport
IEA biological_process
GO:0043306 positive regulation of ma
st cell degranulation
IEA biological_process
GO:0043306 positive regulation of ma
st cell degranulation
IBA biological_process
GO:0045471 response to ethanol
IEA biological_process
GO:0048661 positive regulation of sm
ooth muscle cell prolifer
ation
IEA biological_process
GO:0050714 positive regulation of pr
otein secretion
IEA biological_process
GO:0051281 positive regulation of re
lease of sequestered calc
ium ion into cytosol
IEA biological_process
GO:0071260 cellular response to mech
anical stimulus
IEA biological_process
GO:0071345 cellular response to cyto
kine stimulus
IEA biological_process
GO:0071345 cellular response to cyto
kine stimulus
IBA biological_process
GO:0071635 negative regulation of tr
ansforming growth factor
beta production
IEA biological_process
GO:1901215 negative regulation of ne
uron death
IEA biological_process
GO:1901247 negative regulation of lu
ng ciliated cell differen
tiation
NAS biological_process
GO:1901251 positive regulation of lu
ng goblet cell differenti
ation
NAS biological_process
GO:1903660 negative regulation of co
mplement-dependent cytoto
xicity
IMP biological_process
GO:2000231 positive regulation of pa
ncreatic stellate cell pr
oliferation
IEA biological_process
GO:2000352 negative regulation of en
dothelial cell apoptotic
process
IMP biological_process
GO:0002639 positive regulation of im
munoglobulin production
IBA biological_process
GO:0005125 cytokine activity
TAS molecular_function
GO:0005144 interleukin-13 receptor b
inding
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0005615 extracellular space
ISS cellular_component
GO:0006928 movement of cell or subce
llular component
TAS biological_process
GO:0006954 inflammatory response
TAS biological_process
GO:0007165 signal transduction
NAS biological_process
GO:0007267 cell-cell signaling
IC biological_process
GO:0030890 positive regulation of B
cell proliferation
IBA biological_process
GO:0043032 positive regulation of ma
crophage activation
IBA biological_process
GO:0043306 positive regulation of ma
st cell degranulation
IBA biological_process
GO:0071345 cellular response to cyto
kine stimulus
IBA biological_process
GO:1901247 negative regulation of lu
ng ciliated cell differen
tiation
NAS biological_process
GO:1901251 positive regulation of lu
ng goblet cell differenti
ation
NAS biological_process
GO:1903660 negative regulation of co
mplement-dependent cytoto
xicity
IMP biological_process
GO:2000352 negative regulation of en
dothelial cell apoptotic
process
IMP biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05162  Measles
hsa04657  IL-17 signaling pathway
hsa05321  Inflammatory bowel disease
hsa04658  Th1 and Th2 cell differentiation
hsa04664  Fc epsilon RI signaling pathway
hsa05310  Asthma

Diseases

Associated diseases References
Allergic rhinitis KEGG: H01360, OMIM: 147683
Asthma KEGG: H00079
Atopic dermatitis PMID: 12413765
Atopic dermatitis KEGG: H01358
Atopy PMID: 15969687
Bullous pemphigoid PMID: 16403098
Cancer PMID: 19773451
Chronic obstructive pulmonary disease (COPD) PMID: 15596681
Coronary artery disease PMID: 18612209
Crohn's disease PMID: 17183946
Dermatitis PMID: 16681592
Diabetes PMID: 19479237
Endometriosis PMID: 15255283
Erythema nodosum PMID: 19225544
Gastric atrophy PMID: 15904474
Graves disease PMID: 14510917
Hodgkin disease PMID: 22286212
Juvenile arthritis PMID: 14564352
Lung disease PMID: 12594065
Mastocytosis PMID: 19178408
Migraine disorders PMID: 19559392
Nephrotic syndrome PMID: 11980568
Onchocerciasis PMID: 11825773
Polycystic ovary syndrome (PCOS) PMID: 12798884
Endometriosis INFBASE9222022
Psoriasis PMID: 17388919
Rheumatoid arthritis PMID: 18625055
Rhinitis PMID: 12928861
Sjogren's syndrome PMID: 16166103

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
15255283 Endometrio
sis

80 women while
they were under
going laparosco
py for pain,inf
ertility, tubal
ligation or re
-anastomosis
IL-12
IL-13
Show abstract
12765345 Endometrio
sis


IL-13
IL-15
Show abstract
9222022 Endometrio
sis


IL-13
Show abstract
28433374 Endometrio
sis

107 female infe
rtility (56 end
ometriosis pati
ents, 38 patien
ts without endo
metriosis)
Female infertility
Show abstract