Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 3605
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol IL17A   Gene   UCSC   Ensembl
Aliases CTLA-8, CTLA8, IL-17, IL-17A, IL17
Gene name interleukin 17A
Alternate names interleukin-17A, cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein 8, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8),
Gene location 6p12.2 (52186386: 52190637)     Exons: 3     NC_000006.12
Gene summary(Entrez) The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
OMIM 603149

Protein Summary

Protein general information Q16552  

Name: Interleukin 17A (IL 17) (IL 17A) (Cytotoxic T lymphocyte associated antigen 8) (CTLA 8)

Length: 155  Mass: 17,504

Tissue specificity: Restricted to activated memory T-cells.

Sequence MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWN
LHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPI
VHHVA
Structural information
Interpro:  IPR029034 IPR020440 IPR010345

Pfam:  
PF06083

PDB:  
2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5
PDBsum:   2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5

DIP:  
6014
STRING:   ENSP00000344192;
Other Databases GeneCards:  IL17A;  Malacards:  IL17A

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005125 cytokine activity
IEA molecular_function
GO:0005126 cytokine receptor binding
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0006915 apoptotic process
TAS biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0006955 immune response
TAS biological_process
GO:0007166 cell surface receptor sig
naling pathway
IBA biological_process
GO:0007267 cell-cell signaling
TAS biological_process
GO:0008219 cell death
TAS biological_process
GO:0009897 external side of plasma m
embrane
IEA cellular_component
GO:0010940 positive regulation of ne
crotic cell death
IEA biological_process
GO:0032747 positive regulation of in
terleukin-23 production
IDA biological_process
GO:0043200 response to amino acid
IEA biological_process
GO:0045672 positive regulation of os
teoclast differentiation
IDA biological_process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
IDA biological_process
GO:0050832 defense response to fungu
s
IEA biological_process
GO:0071347 cellular response to inte
rleukin-1
IEA biological_process
GO:0071385 cellular response to gluc
ocorticoid stimulus
IEA biological_process
GO:0072537 fibroblast activation
IDA biological_process
GO:1900017 positive regulation of cy
tokine production involve
d in inflammatory respons
e
IEA biological_process
GO:2000778 positive regulation of in
terleukin-6 secretion
IEA biological_process
GO:0005125 cytokine activity
IEA molecular_function
GO:0005125 cytokine activity
IEA molecular_function
GO:0005125 cytokine activity
IEA molecular_function
GO:0005125 cytokine activity
TAS molecular_function
GO:0005126 cytokine receptor binding
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
TAS cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0006915 apoptotic process
TAS biological_process
GO:0006954 inflammatory response
IEA biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0006955 immune response
TAS biological_process
GO:0007166 cell surface receptor sig
naling pathway
IBA biological_process
GO:0007267 cell-cell signaling
TAS biological_process
GO:0008219 cell death
TAS biological_process
GO:0009897 external side of plasma m
embrane
IEA cellular_component
GO:0010940 positive regulation of ne
crotic cell death
IEA biological_process
GO:0032747 positive regulation of in
terleukin-23 production
IDA biological_process
GO:0043200 response to amino acid
IEA biological_process
GO:0045672 positive regulation of os
teoclast differentiation
IDA biological_process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
IEA biological_process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
IDA biological_process
GO:0050832 defense response to fungu
s
IEA biological_process
GO:0071347 cellular response to inte
rleukin-1
IEA biological_process
GO:0071385 cellular response to gluc
ocorticoid stimulus
IEA biological_process
GO:0072537 fibroblast activation
IDA biological_process
GO:1900017 positive regulation of cy
tokine production involve
d in inflammatory respons
e
IEA biological_process
GO:2000778 positive regulation of in
terleukin-6 secretion
IEA biological_process
GO:0005125 cytokine activity
TAS molecular_function
GO:0005126 cytokine receptor binding
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
TAS cellular_component
GO:0006915 apoptotic process
TAS biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0006955 immune response
TAS biological_process
GO:0007166 cell surface receptor sig
naling pathway
IBA biological_process
GO:0007267 cell-cell signaling
TAS biological_process
GO:0008219 cell death
TAS biological_process
GO:0032747 positive regulation of in
terleukin-23 production
IDA biological_process
GO:0045672 positive regulation of os
teoclast differentiation
IDA biological_process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
IDA biological_process
GO:0072537 fibroblast activation
IDA biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa04659  Th17 cell differentiation
hsa04657  IL-17 signaling pathway
hsa05323  Rheumatoid arthritis
hsa05321  Inflammatory bowel disease

Diseases

Associated diseases References
Asthma PMID: 19210369
Cancer PMID: 19904747
Endometrial cancer PMID: 26744532
Endometriosis PMID: 16008887
Gastric mucosa PMID: 19724898
Multiple sclerosis PMID: 18563468
Endometriosis INFBASE25772772
Polycystic ovary syndrome (PCOS) PMID: 24927491
Polycystic ovary syndrome (PCOS) INFBASE24927491
Endometrioma INFBASE20074813
Varicocele INFBASE24927491
Endometriosis associated infertility INFBASE16045534
Endometriosis INFBASE16008887
Rheumatoid arthritis PMID: 19208686
Unexplained infertility PMID: 24368037

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
26259585 Endometrio
sis


G-CSF
CXCL12
CXCL1
VEGF
IL-8
CX3CL1
Show abstract
16008887 Endometrio
sis

62 (36 patients
with different
stage endometr
iosis, 26 patie
nts without end
ometriosis)
Female infertility IL-17
Show abstract
20074813 Endometrio
sis


IL-6
IL-8
IL-13
IL-17 and CA-125
Show abstract
16045534 Endometrio
sis


Female infertility
Show abstract
18079209 Endometrio
sis


IL-17A
Show abstract
24927491 Endometrio
sis

47 (8 tubal fac
tor, 10 severe
endometriosis,
8 PCOS, 9 contr
ol women )
Male infertility, Female infertility
Show abstract
25772772 Endometrio
sis

48 (24 women wi
th peritoneal a
nd/or ovarian e
ndometriosis, 2
4 controls)
let-7b
7d
7f
Show abstract