Endometriosis Knowledgebase

Search Result

Gene id

3620

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

IDO1 Gene UCSC Ensembl

Aliases

IDO, IDO-1, INDO

Gene name

indoleamine 2,3-dioxygenase 1

Alternate names

indoleamine 2,3-dioxygenase 1, indolamine 2,3 dioxygenase, indole 2,3-dioxygenase, indoleamine-pyrrole 2,3-dioxygenase,

Gene location

8p11.21 (39913808: 39928789) Exons: 10 NC_000008.11

Gene summary(Entrez)

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

OMIM

147435

Protein Summary

Protein general information

P14902

Name: Indoleamine 2,3 dioxygenase 1 (IDO 1) (EC 1.13.11.52) (Indoleamine pyrrole 2,3 dioxygenase)

Length: 403 Mass: 45,326

Tissue specificity: Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as

Sequence

MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKS
QRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDV
LFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKA
FFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLE
AKGTGGTDLMNFLKTVRSTTEKSLLKEG

Structural information

Interpro:	IPR000898
Prosite:	PS00876 PS00877
Pfam:	PF01231
PDB:	2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW
PDBsum:	2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW
MINT:	1414454
STRING:	ENSP00000430505;

Other Databases

GeneCards: IDO1; Malacards: IDO1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002376	immune system process	IEA	biological_process
GO:0002534	cytokine production invol ved in inflammatory respo nse	IEA	biological_process
GO:0002666	positive regulation of T cell tolerance induction	IEA	biological_process
GO:0002678	positive regulation of ch ronic inflammatory respon se	IEA	biological_process
GO:0002830	positive regulation of ty pe 2 immune response	IEA	biological_process
GO:0004833	tryptophan 2,3-dioxygenas e activity	EXP	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0006569	tryptophan catabolic proc ess	TAS	biological_process
GO:0007565	female pregnancy	TAS	biological_process
GO:0009055	electron carrier activity	TAS	molecular_function
GO:0019441	tryptophan catabolic proc ess to kynurenine	IEA	biological_process
GO:0020037	heme binding	IEA	molecular_function
GO:0030485	smooth muscle contractile fiber	IEA	cellular_component
GO:0032421	stereocilium bundle	IEA	cellular_component
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0032693	negative regulation of in terleukin-10 production	IEA	biological_process
GO:0032735	positive regulation of in terleukin-12 production	IEA	biological_process
GO:0033555	multicellular organismal response to stress	IEA	biological_process
GO:0033754	indoleamine 2,3-dioxygena se activity	IMP	molecular_function
GO:0034276	kynurenic acid biosynthet ic process	IEA	biological_process
GO:0036269	swimming behavior	IEA	biological_process
GO:0042130	negative regulation of T cell proliferation	IEA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0055114	oxidation-reduction proce ss	IEA	biological_process
GO:0070233	negative regulation of T cell apoptotic process	IEA	biological_process
GO:0070234	positive regulation of T cell apoptotic process	IMP	biological_process
GO:0046006	regulation of activated T cell proliferation	IMP	biological_process
GO:0002376	immune system process	IEA	biological_process
GO:0002534	cytokine production invol ved in inflammatory respo nse	IEA	biological_process
GO:0002666	positive regulation of T cell tolerance induction	IEA	biological_process
GO:0002678	positive regulation of ch ronic inflammatory respon se	IEA	biological_process
GO:0002830	positive regulation of ty pe 2 immune response	IEA	biological_process
GO:0004833	tryptophan 2,3-dioxygenas e activity	IEA	molecular_function
GO:0004833	tryptophan 2,3-dioxygenas e activity	EXP	molecular_function
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005829	cytosol	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006569	tryptophan catabolic proc ess	IEA	biological_process
GO:0006569	tryptophan catabolic proc ess	TAS	biological_process
GO:0006569	tryptophan catabolic proc ess	TAS	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0007565	female pregnancy	TAS	biological_process
GO:0009055	electron carrier activity	TAS	molecular_function
GO:0016491	oxidoreductase activity	IEA	molecular_function
GO:0019441	tryptophan catabolic proc ess to kynurenine	IEA	biological_process
GO:0019441	tryptophan catabolic proc ess to kynurenine	IEA	biological_process
GO:0020037	heme binding	IEA	molecular_function
GO:0030485	smooth muscle contractile fiber	IEA	cellular_component
GO:0032421	stereocilium bundle	IEA	cellular_component
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0032693	negative regulation of in terleukin-10 production	IEA	biological_process
GO:0032735	positive regulation of in terleukin-12 production	IEA	biological_process
GO:0033555	multicellular organismal response to stress	IEA	biological_process
GO:0033754	indoleamine 2,3-dioxygena se activity	IEA	molecular_function
GO:0033754	indoleamine 2,3-dioxygena se activity	IMP	molecular_function
GO:0034276	kynurenic acid biosynthet ic process	IEA	biological_process
GO:0036269	swimming behavior	IEA	biological_process
GO:0042130	negative regulation of T cell proliferation	IEA	biological_process
GO:0043065	positive regulation of ap optotic process	IEA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0051213	dioxygenase activity	IEA	molecular_function
GO:0055114	oxidation-reduction proce ss	IEA	biological_process
GO:0070233	negative regulation of T cell apoptotic process	IEA	biological_process
GO:0070234	positive regulation of T cell apoptotic process	IMP	biological_process
GO:0046006	regulation of activated T cell proliferation	IMP	biological_process
GO:0004833	tryptophan 2,3-dioxygenas e activity	EXP	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0006569	tryptophan catabolic proc ess	TAS	biological_process
GO:0006569	tryptophan catabolic proc ess	TAS	biological_process
GO:0007565	female pregnancy	TAS	biological_process
GO:0009055	electron carrier activity	TAS	molecular_function
GO:0033754	indoleamine 2,3-dioxygena se activity	IMP	molecular_function
GO:0070234	positive regulation of T cell apoptotic process	IMP	biological_process
GO:0046006	regulation of activated T cell proliferation	IMP	biological_process

KEGG pathways

hsa01100  Metabolic pathways
hsa05143  African trypanosomiasis
hsa00380  Tryptophan metabolism

Diseases

Associated diseases	References
Endometriosis	PMID: 22638210
Multiple sclerosis	PMID: 19604093
Pregnancy loss	PMID: 16135011
Endometriosis	INFBASE22638210

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
22638210	Endometrio sis					IDO1 COX-2 MMP-9	Show abstract