Endometriosis Knowledgebase

Search Result

Gene id

3646

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

EIF3E Gene UCSC Ensembl

Aliases

EIF3-P48, EIF3S6, INT6, eIF3-p46

Gene name

eukaryotic translation initiation factor 3 subunit E

Alternate names

eukaryotic translation initiation factor 3 subunit E, eIF-3 p48, eukaryotic translation initiation factor 3 subunit 6, eukaryotic translation initiation factor 3 subunit E isoform 2 transcript, eukaryotic translation initiation factor 3, subunit 6 (48kD), eukaryotic translation initiation factor 3, subunit 6 48kDa, mammary tumor-associated protein INT6, murine mammary tumor integration site 6 (oncogene homolog), viral integration site protein INT-6 homolog,

Gene location

8q23.1 (64185271: 64204547) Exons: 15 NC_000011.10

OMIM

602210

Protein Summary

Protein general information

P60228

Name: Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48)

Length: 445 Mass: 52,221

Tissue specificity: Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus. {ECO

Sequence

MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRT
TVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEY
LYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNH
PKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLY
VNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLI
RNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY

Structural information

Protein Domains	PCI. (221-398)
Interpro:	IPR016650 IPR019010 IPR000717 IPR036388 IPR036390
Prosite:	PS50250
Pfam:	PF09440 PF01399
PDB:	3J8B 3J8C 6FEC
PDBsum:	3J8B 3J8C 6FEC
DIP:	32691
MINT:
STRING:	ENSP00000220849;

Other Databases

GeneCards: EIF3E; Malacards: EIF3E

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsen se-mediated decay	IMP	biological_process
GO:0001731	formation of translation preinitiation complex	IEA	biological_process
GO:0003743	translation initiation fa ctor activity	IC	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	NAS	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	NAS	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0006413	translational initiation	IC	biological_process
GO:0006413	translational initiation	IDA	biological_process
GO:0006413	translational initiation	IC	biological_process
GO:0006413	translational initiation	TAS	biological_process
GO:0006446	regulation of translation al initiation	NAS	biological_process
GO:0006446	regulation of translation al initiation	NAS	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0016282	eukaryotic 43S preinitiat ion complex	IEA	cellular_component
GO:0033290	eukaryotic 48S preinitiat ion complex	IEA	cellular_component
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045947	negative regulation of tr anslational initiation	NAS	biological_process
GO:0047485	protein N-terminus bindin g	IPI	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0000785	chromatin	NAS	cellular_component
GO:0016605	PML body	IDA	cellular_component
GO:0003743	translation initiation fa ctor activity	IC	molecular_function
GO:0003743	translation initiation fa ctor activity	IDA	molecular_function
GO:0003743	translation initiation fa ctor activity	IC	molecular_function
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsen se-mediated decay	IMP	biological_process
GO:0001731	formation of translation preinitiation complex	IEA	biological_process
GO:0003743	translation initiation fa ctor activity	IEA	molecular_function
GO:0003743	translation initiation fa ctor activity	IEA	molecular_function
GO:0003743	translation initiation fa ctor activity	IEA	molecular_function
GO:0003743	translation initiation fa ctor activity	IEA	molecular_function
GO:0003743	translation initiation fa ctor activity	IC	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	NAS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IEA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IEA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IEA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	NAS	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0006412	translation	IEA	biological_process
GO:0006413	translational initiation	IEA	biological_process
GO:0006413	translational initiation	IEA	biological_process
GO:0006413	translational initiation	IEA	biological_process
GO:0006413	translational initiation	IC	biological_process
GO:0006413	translational initiation	IDA	biological_process
GO:0006413	translational initiation	IC	biological_process
GO:0006413	translational initiation	TAS	biological_process
GO:0006446	regulation of translation al initiation	IEA	biological_process
GO:0006446	regulation of translation al initiation	NAS	biological_process
GO:0006446	regulation of translation al initiation	NAS	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0016282	eukaryotic 43S preinitiat ion complex	IEA	cellular_component
GO:0016605	PML body	IEA	cellular_component
GO:0033290	eukaryotic 48S preinitiat ion complex	IEA	cellular_component
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045947	negative regulation of tr anslational initiation	NAS	biological_process
GO:0047485	protein N-terminus bindin g	IPI	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0000785	chromatin	NAS	cellular_component
GO:0016605	PML body	IDA	cellular_component
GO:0003743	translation initiation fa ctor activity	IC	molecular_function
GO:0003743	translation initiation fa ctor activity	IDA	molecular_function
GO:0003743	translation initiation fa ctor activity	IC	molecular_function
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsen se-mediated decay	IMP	biological_process
GO:0003743	translation initiation fa ctor activity	IC	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	NAS	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	NAS	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0005852	eukaryotic translation in itiation factor 3 complex	IDA	cellular_component
GO:0006413	translational initiation	IC	biological_process
GO:0006413	translational initiation	IDA	biological_process
GO:0006413	translational initiation	IC	biological_process
GO:0006413	translational initiation	TAS	biological_process
GO:0006446	regulation of translation al initiation	NAS	biological_process
GO:0006446	regulation of translation al initiation	NAS	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045947	negative regulation of tr anslational initiation	NAS	biological_process
GO:0047485	protein N-terminus bindin g	IPI	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0000785	chromatin	NAS	cellular_component
GO:0016605	PML body	IDA	cellular_component
GO:0003743	translation initiation fa ctor activity	IC	molecular_function
GO:0003743	translation initiation fa ctor activity	IDA	molecular_function
GO:0003743	translation initiation fa ctor activity	IC	molecular_function

KEGG pathways

hsa05160 Hepatitis C
hsa03013 RNA transport

Diseases

Associated diseases	References
Endometriosis	INFBASE28438065

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
28438065	Endometrio sis					TGFB1 Snail CDH1 VIM PCNA	Show abstract