Search Result
Gene id | 3717 | ||||||||||||||||||||
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Gene Summary Protein Summary KEGG pathways Diseases PubMed references | |||||||||||||||||||||
Gene Summary |
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Gene Symbol | JAK2 Gene UCSC Ensembl | ||||||||||||||||||||
Aliases | JTK10, THCYT3 | ||||||||||||||||||||
Gene name | Janus kinase 2 | ||||||||||||||||||||
Alternate names | tyrosine-protein kinase JAK2, JAK-2, Janus kinase 2 (a protein tyrosine kinase), | ||||||||||||||||||||
Gene location |
9p24.1 (4985085: 5128182) Exons: 26 NC_000009.12 |
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Gene summary(Entrez) |
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008] |
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OMIM | 147796 | ||||||||||||||||||||
Protein Summary |
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Protein general information | O60674 Name: Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) Length: 1132 Mass: 1,30,674 Tissue specificity: Ubiquitously expressed throughout most tissues. {ECO | ||||||||||||||||||||
Sequence |
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKAC GITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILT RKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRL TADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPT LQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVC AKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG DKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNM RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHR DLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTY IEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ IRDNMAG | ||||||||||||||||||||
Structural information |
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Other Databases | GeneCards: JAK2;  Malacards: JAK2 | ||||||||||||||||||||
Gene ontology |
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KEGG pathways
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hsa05140 Leishmaniasis hsa04062 Chemokine signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cel hsa01521 EGFR tyrosine kinase inhibitor resistance hsa04725 Cholinergic synapse hsa05168 Herpes simplex infection hsa05145 Toxoplasmosis hsa04920 Adipocytokine signaling pathway hsa05164 Influenza A hsa04630 JAK-STAT signaling pathway hsa05162 Measles hsa04151 PI3K-Akt signaling pathway hsa04217 Necroptosis hsa04933 AGE-RAGE signaling pathway in diabetic complications hsa05152 Tuberculosis hsa05167 Kaposi sarcoma hsa05200 Pathways in cancer hsa04659 Th17 cell differentiation hsa04658 Th1 and Th2 cell differentiation hsa04917 Prolactin signaling pathway | |||||||||||||||||||||
Diseases
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PubMed references |
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