Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 3911
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol LAMA5   Gene   UCSC   Ensembl
Gene name laminin subunit alpha 5
Alternate names laminin subunit alpha-5, laminin alpha-5 chain, laminin-10 subunit alpha, laminin-11 subunit alpha, laminin-15 subunit alpha,
Gene location 20q13.33 (62367317: 62309059)     Exons: 81     NC_000020.11
Gene summary(Entrez) This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
OMIM 601033

Protein Summary
Protein general information O15230  

Name: Laminin subunit alpha 5 (Laminin 10 subunit alpha) (Laminin 11 subunit alpha) (Laminin 15 subunit alpha)

Length: 3695  Mass: 399,737

Tissue specificity: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.

Sequence MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPR
PTEDLYCKLVGGPVAGGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQ
VFHVAYVLIKFANSPRPDLWVLERSMDFGRTYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPL
ENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKALRDPTVTRRYYYSIKDISIGGRC
VCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNCYGHATDCYYDPEVD
RRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCR
PNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTH
CELCAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCD
EAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCV
PCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHV
EGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFG
CRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFGFNPLEFEN
FSWRGYAQMAPVQPRIVARLNLTSPDLFWLVFRYVNRGAMSVSGRVSVREEGRSATCANCTAQSQPVAFPPSTEP
AFITVPQRGFGEPFVLNPGTWALRVEAEGVLLDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHL
PLDGFPSAAGLEALCRQDNSLPRPCPTEQLSPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVG
VAVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSEASVRLTAEQARFFLHGVTLVPIEEFSPEFV
EPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGLPLTHAQDLTPAMSPAGPRPRPPTAVDPDA
EPTLLREPQATVVFTTHVPTLGRYAFLLHGYQPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQA
LLDVTHSELTVTVRVPKGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAA
SLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCIC
PPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCR
PCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFCFGATERCRSSSYTRQEFVDM
EGWVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGGTLRYELHSETQRGDV
FVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREELMMVLASLEQLQIRALFS
QISSAVFLRRVALEVASPAGQGALASNVELCLCPASYRGDSCQECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLP
GSGVCVDCQHNTEGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAGASCER
CAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAPGFYGNALLPGNCTRCDC
TPCGTEACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCR
ECAPGYWGLPEQGCRRCQCPGGRCDPHTGRCNCPPGLSGERCDTCSQQHQVPVPGGPVGHSIHCEVCDHCVVLLL
DDLERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRL
GGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANASAPSGEQLLRTLAEVERLLWE
MRARDLGAPQAAAEAELAAAQRLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQE
LNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTF
SPAGSKLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTW
ATVVRQGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDET
SKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSIL
ENRGVHNASLALSASIGRVRELIAQARGAASKVKVPMKFNGRSGVQLRTPRDLADLAAYTALKFYLQGPEPEPGQ
GTEDRFVMYMGSRQATGDYMGVSLRDKKVHWVYQLGEAGPAVLSIDEDIGEQFAAVSLDRTLQFGHMSVTVERQM
IQETKGDTVAPGAEGLLNLRPDDFVFYVGGYPSTFTPPPLLRFPGYRGCIEMDTLNEEVVSLYNFERTFQLDTAV
DRPCARSKSTGDPWLTDGSYLDGTGFARISFDSQISTTKRFEQELRLVSYSGVLFFLKQQSQFLCLAVQEGSLVL
LYDFGAGLKKAVPLQPPPPLTSASKAIQVFLLGGSRKRVLVRVERATVYSVEQDNDLELADAYYLGGVPPDQLPP
SLRRLFPTGGSVRGCVKGIKALGKYVDLKRLNTTGVSAGCTADLLVGRAMTFHGHGFLRLALSNVAPLTGNVYSG
FGFHSAQDSALLYYRASPDGLCQVSLQQGRVSLQLLRTEVKTQAGFADGAPHYVAFYSNATGVWLYVDDQLQQMK
PHRGPPPELQPQPEGPPRLLLGGLPESGTIYNFSGCISNVFVQRLLGPQRVFDLQQNLGSVNVSTGCAPALQAQT
PGLGPRGLQATARKASRRSRQPARHPACMLPPHLRTTRDSYQFGGSLSSHLEFVGILARHRNWPSLSMHVLPRSS
RGLLLFTARLRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQRSRPGRWHKVSVRWEKNRILLVTDGARAWSQE
GPHRQHQGAEHPQPHTLFVGGLPASSHSSKLPVTVGFSGCVKRLRLHGRPLGAPTRMAGVTPCILGPLEAGLFFP
GSGGVITLDLPGATLPDVGLELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGEFSTSVTRPSVL
CDGQWHRLAVMKSGNVLRLEVDAQSNHTVGPLLAAAAGAPAPLYLGGLPEPMAVQPWPPAYCGCMRRLAVNRSPV
AMTRSVEVHGAVGASGCPAA
Structural information
Protein Domains
 Laminin (41-299)
Laminin (300-358)
Laminin (359-428)
Laminin (429-474)

Motifs
 Cell attachment(1722-1724)
Cell attachment(1838-1840)
Interpro:  IPR013320 IPR000742 IPR008979 IPR009254 IPR010307 IPR002049 IPR001791 IPR000034 IPR008211 IPR001368
Prosite:   PS00022 PS01186 PS01248 PS50027 PS50025 PS51115 PS51117

Pfam:  		 PF00052 PF00053 PF02210 PF06008 PF06009 PF00055
MINT:   1183475
STRING:   ENSP00000252999;
Other Databases GeneCards:  LAMA5;MIR4758;  Malacards:  LAMA5

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001525 angiogenesis
 NAS biological_process
GO:0001658 branching involved in ure
teric bud morphogenesis
 IEA biological_process
GO:0001738 morphogenesis of a polari
zed epithelium
 IEA biological_process
GO:0001755 neural crest cell migrati
on
 IEA biological_process
GO:0001942 hair follicle development
 IEA biological_process
GO:0005178 integrin binding
 IDA molecular_function
GO:0005198 structural molecule activ
ity
 IC molecular_function
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005604 basement membrane
 IDA cellular_component
GO:0005605 basal lamina
 NAS cellular_component
GO:0005610 laminin-5 complex
 IEA cellular_component
GO:0005615 extracellular space
 IDA cellular_component
GO:0005634 nucleus
 IDA cellular_component
GO:0007010 cytoskeleton organization
 NAS biological_process
GO:0007229 integrin-mediated signali
ng pathway
 IMP biological_process
GO:0007517 muscle organ development
 IEA biological_process
GO:0008037 cell recognition
 NAS biological_process
GO:0008283 cell proliferation
 NAS biological_process
GO:0009790 embryo development
 NAS biological_process
GO:0016331 morphogenesis of embryoni
c epithelium
 IEA biological_process
GO:0016477 cell migration
 IDA biological_process
GO:0030154 cell differentiation
 NAS biological_process
GO:0030155 regulation of cell adhesi
on
 IEA biological_process
GO:0030198 extracellular matrix orga
nization
 TAS biological_process
GO:0030324 lung development
 IEA biological_process
GO:0030334 regulation of cell migrat
ion
 IEA biological_process
GO:0031012 extracellular matrix
 IDA cellular_component
GO:0034446 substrate adhesion-depend
ent cell spreading
 IDA biological_process
GO:0042127 regulation of cell prolif
eration
 IEA biological_process
GO:0042475 odontogenesis of dentin-c
ontaining tooth
 IEA biological_process
GO:0043259 laminin-10 complex
 IDA cellular_component
GO:0043259 laminin-10 complex
 TAS cellular_component
GO:0043260 laminin-11 complex
 TAS cellular_component
GO:0045446 endothelial cell differen
tiation
 NAS biological_process
GO:0045995 regulation of embryonic d
evelopment
 IEA biological_process
GO:0048041 focal adhesion assembly
 NAS biological_process
GO:0060445 branching involved in sal
ivary gland morphogenesis
 IEA biological_process
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0090002 establishment of protein
localization to plasma me
mbrane
 IEA biological_process
GO:0031012 extracellular matrix
 IDA cellular_component
GO:0001525 angiogenesis
 NAS biological_process
GO:0001658 branching involved in ure
teric bud morphogenesis
 IEA biological_process
GO:0001738 morphogenesis of a polari
zed epithelium
 IEA biological_process
GO:0001755 neural crest cell migrati
on
 IEA biological_process
GO:0001942 hair follicle development
 IEA biological_process
GO:0005102 receptor binding
 IEA molecular_function
GO:0005178 integrin binding
 IEA molecular_function
GO:0005178 integrin binding
 IDA molecular_function
GO:0005198 structural molecule activ
ity
 IC molecular_function
GO:0005576 extracellular region
 IEA cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
 IEA cellular_component
GO:0005578 proteinaceous extracellul
ar matrix
 IEA cellular_component
GO:0005604 basement membrane
 IEA cellular_component
GO:0005604 basement membrane
 IEA cellular_component
GO:0005604 basement membrane
 IEA cellular_component
GO:0005604 basement membrane
 IDA cellular_component
GO:0005605 basal lamina
 IEA cellular_component
GO:0005605 basal lamina
 NAS cellular_component
GO:0005610 laminin-5 complex
 IEA cellular_component
GO:0005615 extracellular space
 IDA cellular_component
GO:0005634 nucleus
 IDA cellular_component
GO:0007010 cytoskeleton organization
 NAS biological_process
GO:0007155 cell adhesion
 IEA biological_process
GO:0007155 cell adhesion
 IEA biological_process
GO:0007229 integrin-mediated signali
ng pathway
 IMP biological_process
GO:0007517 muscle organ development
 IEA biological_process
GO:0008037 cell recognition
 NAS biological_process
GO:0008283 cell proliferation
 NAS biological_process
GO:0009790 embryo development
 NAS biological_process
GO:0009887 animal organ morphogenesi
s
 IEA biological_process
GO:0016331 morphogenesis of embryoni
c epithelium
 IEA biological_process
GO:0016477 cell migration
 IDA biological_process
GO:0030154 cell differentiation
 NAS biological_process
GO:0030155 regulation of cell adhesi
on
 IEA biological_process
GO:0030198 extracellular matrix orga
nization
 TAS biological_process
GO:0030324 lung development
 IEA biological_process
GO:0030334 regulation of cell migrat
ion
 IEA biological_process
GO:0031012 extracellular matrix
 IDA cellular_component
GO:0034446 substrate adhesion-depend
ent cell spreading
 IDA biological_process
GO:0042127 regulation of cell prolif
eration
 IEA biological_process
GO:0042475 odontogenesis of dentin-c
ontaining tooth
 IEA biological_process
GO:0043259 laminin-10 complex
 IEA cellular_component
GO:0043259 laminin-10 complex
 IDA cellular_component
GO:0043259 laminin-10 complex
 TAS cellular_component
GO:0043260 laminin-11 complex
 TAS cellular_component
GO:0045446 endothelial cell differen
tiation
 NAS biological_process
GO:0045995 regulation of embryonic d
evelopment
 IEA biological_process
GO:0048041 focal adhesion assembly
 NAS biological_process
GO:0048754 branching morphogenesis o
f an epithelial tube
 IEA biological_process
GO:0060445 branching involved in sal
ivary gland morphogenesis
 IEA biological_process
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0090002 establishment of protein
localization to plasma me
mbrane
 IEA biological_process
GO:0031012 extracellular matrix
 IDA cellular_component
GO:0001525 angiogenesis
 NAS biological_process
GO:0005178 integrin binding
 IDA molecular_function
GO:0005198 structural molecule activ
ity
 IC molecular_function
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005576 extracellular region
 TAS cellular_component
GO:0005604 basement membrane
 IDA cellular_component
GO:0005605 basal lamina
 NAS cellular_component
GO:0005615 extracellular space
 IDA cellular_component
GO:0005634 nucleus
 IDA cellular_component
GO:0007010 cytoskeleton organization
 NAS biological_process
GO:0007229 integrin-mediated signali
ng pathway
 IMP biological_process
GO:0008037 cell recognition
 NAS biological_process
GO:0008283 cell proliferation
 NAS biological_process
GO:0009790 embryo development
 NAS biological_process
GO:0016477 cell migration
 IDA biological_process
GO:0030154 cell differentiation
 NAS biological_process
GO:0030198 extracellular matrix orga
nization
 TAS biological_process
GO:0031012 extracellular matrix
 IDA cellular_component
GO:0034446 substrate adhesion-depend
ent cell spreading
 IDA biological_process
GO:0043259 laminin-10 complex
 IDA cellular_component
GO:0043259 laminin-10 complex
 TAS cellular_component
GO:0043260 laminin-11 complex
 TAS cellular_component
GO:0045446 endothelial cell differen
tiation
 NAS biological_process
GO:0048041 focal adhesion assembly
 NAS biological_process
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0031012 extracellular matrix
 IDA cellular_component

KEGG pathways

hsa01100  Metabolic pathways
hsa05200  Pathways in cancer
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05222  Small cell lung cancer
hsa04512  ECM-receptor interaction

Diseases

Associated diseases References
Cancer PMID: 20972440
Endometriosis PMID: 24188612
Endometriosis INFBASE24188612

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
24188612 Endometrio
sis
32 (18 with end
ometriosis, 14
controls)
 AKT1
TYMP
JAG1
LAMA5
TIMP-1
 Show abstract
17291260 Endometrio
sis

Ln-5
alpha3beta1
 Show abstract