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Gene id

3958

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

LGALS3 Gene UCSC Ensembl

Aliases

CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2

Gene name

galectin 3

Alternate names

galectin-3, 35 kDa lectin, IgE-binding protein, MAC-2 antigen, advanced glycation end-product receptor 3, carbohydrate-binding protein 35, galactose-specific lectin 3, laminin-binding protein, lectin L-29, lectin, galactoside-binding, soluble, 3,

Gene location

14q22.3 (55129216: 55145429) Exons: 7 NC_000014.9

Gene summary(Entrez)

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

OMIM

153619

Protein Summary

Protein general information

P17931

Name: Galectin 3 (Gal 3) (35 kDa lectin) (Carbohydrate binding protein 35) (CBP 35) (Galactose specific lectin 3) (Galactoside binding protein) (GALBP) (IgE binding protein) (L 31) (Laminin binding protein) (Lectin L 29) (Mac 2 antigen)

Length: 250 Mass: 26,152

Tissue specificity: A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. {ECO

Sequence

MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPA
PGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQ
RGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRV
KKLNEISKLGISGDIDLTSASYTMI

Structural information

Protein Domains	Galectin. (118-248)
Motifs	Nuclear export(226-241)
Interpro:	IPR013320 IPR015534 IPR001079
Prosite:	PS51304
Pfam:	PF00337
PDB:	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ
PDBsum:	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ
DIP:	45623
STRING:	ENSP00000254301;

Other Databases

GeneCards: LGALS3; Malacards: LGALS3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001772	immunological synapse	IDA	cellular_component
GO:0002548	monocyte chemotaxis	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005681	spliceosomal complex	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005743	mitochondrial inner membr ane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006397	mRNA processing	IEA	biological_process
GO:0008380	RNA splicing	IEA	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0019863	IgE binding	IDA	molecular_function
GO:0030246	carbohydrate binding	IEA	molecular_function
GO:0030593	neutrophil chemotaxis	IDA	biological_process
GO:0030855	epithelial cell different iation	IEP	biological_process
GO:0042056	chemoattractant activity	IDA	molecular_function
GO:0042129	regulation of T cell prol iferation	IMP	biological_process
GO:0043236	laminin binding	IDA	molecular_function
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045087	innate immune response	IEA	biological_process
GO:0045806	negative regulation of en docytosis	IDA	biological_process
GO:0048245	eosinophil chemotaxis	IDA	biological_process
GO:0048246	macrophage chemotaxis	IDA	biological_process
GO:0050860	negative regulation of T cell receptor signaling p athway	ISS	biological_process
GO:0050918	positive chemotaxis	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070232	regulation of T cell apop totic process	IDA	biological_process
GO:0071674	mononuclear cell migratio n	IDA	biological_process
GO:0071677	positive regulation of mo nonuclear cell migration	IDA	biological_process
GO:0090280	positive regulation of ca lcium ion import	IDA	biological_process
GO:1902041	regulation of extrinsic a poptotic signaling pathwa y via death domain recept ors	IMP	biological_process
GO:2000521	negative regulation of im munological synapse forma tion	ISS	biological_process
GO:2001189	negative regulation of T cell activation via T cel l receptor contact with a ntigen bound to MHC molec ule on antigen presenting cell	ISS	biological_process
GO:2001237	negative regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001200	positive regulation of de ndritic cell differentiat ion	IDA	biological_process
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0001772	immunological synapse	IDA	cellular_component
GO:0002376	immune system process	IEA	biological_process
GO:0002548	monocyte chemotaxis	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005681	spliceosomal complex	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005743	mitochondrial inner membr ane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006397	mRNA processing	IEA	biological_process
GO:0008380	RNA splicing	IEA	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0019863	IgE binding	IEA	molecular_function
GO:0019863	IgE binding	IDA	molecular_function
GO:0030154	cell differentiation	IEA	biological_process
GO:0030246	carbohydrate binding	IEA	molecular_function
GO:0030246	carbohydrate binding	IEA	molecular_function
GO:0030246	carbohydrate binding	TAS	molecular_function
GO:0030593	neutrophil chemotaxis	IDA	biological_process
GO:0030855	epithelial cell different iation	IEP	biological_process
GO:0042056	chemoattractant activity	IDA	molecular_function
GO:0042129	regulation of T cell prol iferation	IMP	biological_process
GO:0043236	laminin binding	IDA	molecular_function
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045087	innate immune response	IEA	biological_process
GO:0045806	negative regulation of en docytosis	IDA	biological_process
GO:0048245	eosinophil chemotaxis	IDA	biological_process
GO:0048246	macrophage chemotaxis	IDA	biological_process
GO:0050860	negative regulation of T cell receptor signaling p athway	ISS	biological_process
GO:0050918	positive chemotaxis	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070232	regulation of T cell apop totic process	IDA	biological_process
GO:0071674	mononuclear cell migratio n	IDA	biological_process
GO:0071677	positive regulation of mo nonuclear cell migration	IDA	biological_process
GO:0090280	positive regulation of ca lcium ion import	IDA	biological_process
GO:1902041	regulation of extrinsic a poptotic signaling pathwa y via death domain recept ors	IMP	biological_process
GO:2000521	negative regulation of im munological synapse forma tion	ISS	biological_process
GO:2001189	negative regulation of T cell activation via T cel l receptor contact with a ntigen bound to MHC molec ule on antigen presenting cell	ISS	biological_process
GO:2001237	negative regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001200	positive regulation of de ndritic cell differentiat ion	IDA	biological_process
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0001772	immunological synapse	IDA	cellular_component
GO:0002548	monocyte chemotaxis	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005743	mitochondrial inner membr ane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0019863	IgE binding	IDA	molecular_function
GO:0030246	carbohydrate binding	TAS	molecular_function
GO:0030593	neutrophil chemotaxis	IDA	biological_process
GO:0030855	epithelial cell different iation	IEP	biological_process
GO:0042056	chemoattractant activity	IDA	molecular_function
GO:0042129	regulation of T cell prol iferation	IMP	biological_process
GO:0043236	laminin binding	IDA	molecular_function
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045806	negative regulation of en docytosis	IDA	biological_process
GO:0048245	eosinophil chemotaxis	IDA	biological_process
GO:0048246	macrophage chemotaxis	IDA	biological_process
GO:0050860	negative regulation of T cell receptor signaling p athway	ISS	biological_process
GO:0050918	positive chemotaxis	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070232	regulation of T cell apop totic process	IDA	biological_process
GO:0071674	mononuclear cell migratio n	IDA	biological_process
GO:0071677	positive regulation of mo nonuclear cell migration	IDA	biological_process
GO:0090280	positive regulation of ca lcium ion import	IDA	biological_process
GO:1902041	regulation of extrinsic a poptotic signaling pathwa y via death domain recept ors	IMP	biological_process
GO:2000521	negative regulation of im munological synapse forma tion	ISS	biological_process
GO:2001189	negative regulation of T cell activation via T cel l receptor contact with a ntigen bound to MHC molec ule on antigen presenting cell	ISS	biological_process
GO:2001237	negative regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001200	positive regulation of de ndritic cell differentiat ion	IDA	biological_process
GO:0031012	extracellular matrix	IDA	cellular_component

Diseases

Associated diseases	References
Cancer	PMID: 17221114
Endometriosis	PMID: 25069762
Hyperandrogenism	PMID: 24497217
Polycystic ovary syndrome (PCOS)	PMID: 24497217
Endometriosis	INFBASE21030859

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
25069762	Endometrio sis			23 (15 women af fected by endom etriosis, 8 con trols)		Gal-3 ST2	Show abstract
21030859	Endometrio sis			84 (50 cases of endometriosis (peritoneal end ometriosis: n=1 0; ovarian endo metriosis: n=10 ; deeply infilt rating endometr iosis: n=30), 3 4 cases of euto pic endometrium (10 without en dometriosis and 24 with endome triosis))		gal-3	Show abstract