Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 4018
Gene Summary                KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol LPA   Gene   UCSC   Ensembl
Aliases AK38, APOA, LP
Gene name lipoprotein(a)
Alternate names apolipoprotein(a), antiangiogenic AK38 protein, apo(a), lipoprotein, Lp(a), lp(a),
Gene location 6q25.3-q26 (160666374: 160531482)     Exons: 40     NC_000006.12
Gene summary(Entrez) The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
OMIM 152200

Diseases

Associated diseases References
Alzheimer's disease PMID: 12359323
Amyotrophic lateral sclerosis (ALS) PMID: 18513389
Asthma PMID: 18682798
Diabetes PMID: 19479237
Endometriosis PMID: 9225824
Heart disease PMID: 16053196
LPA deficiency OMIM: 152200
Obesity PMID: 19349573
Ovarian hyperstimulation syndrome(OHSS) PMID: 18171700
Endometriosis INFBASE9225824
Polycystic ovary syndrome (PCOS) PMID: 21628302

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
9225824 Endometrio
sis

58 (29 women wi
th endometriosi
s, 29 matched h
ealthy controls
)
Lp(a)
Show abstract