Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 406881
Gene Summary                KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol MIRLET7A1   Gene   UCSC   Ensembl
Aliases LET7A1, MIRNLET7A1, let-7a-1
Gene name microRNA let-7a-1
Alternate names hsa-let-7a-1,
Gene location 9q22.32 (94175956: 94176035)     Exons: 1     NC_000009.12
Gene summary(Entrez) microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
OMIM 605386

KEGG pathways

hsa05206  MicroRNAs in cancer

Diseases

Associated diseases References
Endometriosis PMID: 22307873
Endometriosis INFBASE22307873
Spermatogenetic defects PMID: 22675043

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
22307873 Endometrio
sis
LCS6 polymorphism
150 women with
endometriosis
let-7
Show abstract