Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 406925
Gene Summary                KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol MIR135A1   Gene   UCSC   Ensembl
Aliases MIRN135-1, MIRN135A1, mir-135a-1
Gene name microRNA 135a-1
Alternate names hsa-mir-135-1, hsa-mir-135a-1, microRNA 135-1,
Gene location 3p21.2 (52294307: 52294218)     Exons: 1     NC_000003.12
Gene summary(Entrez) microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

KEGG pathways

hsa05206  MicroRNAs in cancer

Diseases

Associated diseases References
Cryptorchidism PMID: 24184258
Endometriosis PMID: 21956427
Endometriosis INFBASE21956427
Polycystic ovary syndrome (PCOS) PMID: 24390626

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21956427 Endometrio
sis

82 (50 controls
, 32 women with
endometriosis)
miR135a
Show abstract