Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 406983
Gene Summary                KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol MIR200A   Gene   UCSC   Ensembl
Aliases MIRN200A, mir-200a
Gene name microRNA 200a
Alternate names hsa-mir-200a,
Gene location 1p36.33 (1167862: 1167951)     Exons: 1     NC_000001.11
Gene summary(Entrez) microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
OMIM 612090

KEGG pathways

hsa05206  MicroRNAs in cancer

Diseases

Associated diseases References
Endometrial cancer PMID: 28647188
Endometriosis PMID: 19074548
Endometriosis INFBASE26206343
Endometriosis associated infertility INFBASE24495683

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
19074548 Endometrio
sis


Female infertility miR-145
miR-143
miR-99a
miR-99b
miR-126
miR-100
miR-125b
miR-150
miR-125a
miR-223
miR-194
miR-365
miR-29c
miR-1
miR-200a
miR-141
miR-200b
miR-142-3p
miR-424
miR-34c
miR-20a and miR-196b
Show abstract
24495683 Endometrio
sis

80 (36 infertil
e cases with en
dometriosis, 44
healthy women
with male facto
r infertility)
Female infertility
Show abstract
26206343 Endometrio
sis

126 (61 patient
s with endometr
iosis, 65 contr
ol women (35 la
paroscopically
confirmed endom
etriosis-free w
omen, 30 health
y women))
Female infertility
Show abstract